&lt;p&gt;Efek pemberian gel ekstrak biji kopi robusta (Coffea canephora) terhadap jumlah osteoblas dan osteoklas pada tulang alveolar tikus periodontitis&lt;/p&gt;&lt;p&gt;The effect of robusta coffee bean (Coffea canephora) extract gel on the number of osteoblasts and osteoclasts in the alveolar bone of periodontitis rats&lt;/p&gt;

Fatimatuzzahro, Nadie; Ermawati, Tantin; Prasetya, Rendra Chriestedy; Destianingrum, Pintan Qorina

doi:10.24198/pjdrs.v4i2.28383

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…TNF-α is known as an inflammatory cytokine that is often used as an indicator of cellular oxidative stress, apoptosis, or necrosis. TNF-α levels will increase when inflammation occurs [32]. When ulcers occur, pH greatly affects the reactions of biochemical healing processes, including increasing protease activity and oxygen release, reducing bacterial toxicity (antibacterial), triggering angiogenesis, and increasing fibroblast activity [32,33].…”

Section: Discussionmentioning

confidence: 99%

Accelerating Wound Healing of Traumatic Ulcer with Topical Application of Dental Pulp Mesenchymal Stem Cell Secretome and Robusta Green Coffee Bean Extract Combination in vivo

Ichi,

Triwahyuni,

Sari

2023

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective: To investigate the ability of a combination dental pulp mesenchymal stem cell secretome (DPMSCS), robusta green coffee bean extract (RGCBE), and Carboxymethylcellulose-Natrium (CMC-Na) in a Wistar rats model of traumatic ulcers. Material and Methods: Twenty-eight young, male, healthy Wistar rats (Rattus norvegicus) were divided into seven groups randomly: Group K0, group K1-3 (traumatic ulcer rats that received CMC-Na gel for three days), group K1-7 (traumatic ulcer rats that received CMC-Na gel for seven days), group K2-3 (traumatic ulcer rats that received RGCBE for three days), group K2-7 (traumatic ulcer rats that received RGCBE for seven days), group K3-3 (traumatic ulcer rats that received DPMSCS for three days), and group K3-7 (traumatic ulcer rats that received DPMSCS for seven days). An ulcer was made with an amalgam stopper on the right buccal mucosa of the rats. DPMSCS 50% gel was applied to the ulcer on the left buccal mucosa. The ulcer diameter was measured on day 3 and day 7. Results: There was a significant difference in the diameter of the ulcer, the number of neutrophils, and fibroblasts in the treatment group compared to the control group on day 7. Conclusion: A combination of DPMSCS and RGCBE 50% accelerates traumatic ulcer wound healing by lowering ulcer diameter, decreasing neutrophil counts, and increasing fibroblast proliferation in vivo.

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Section: Discussionmentioning

confidence: 99%

Accelerating Wound Healing of Traumatic Ulcer with Topical Application of Dental Pulp Mesenchymal Stem Cell Secretome and Robusta Green Coffee Bean Extract Combination in vivo

Ichi,

Triwahyuni,

Sari

2023

Pesqui. Bras. Odontopediatria Clín. Integr.

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“…These cytokines may activate macrophages, so that macrophages release other cytokines to activate lymphocytes and causes inflammation where there is a focus of both these cells stimulate each other to destroy the antigen. 40 Robusta coffee bean extract contains active compounds, namely, polyphenols, alkaloids, and saponins which act as an anti-inflammatory agent by inhibiting Polymorphonuclear leukocytes (PMN)s and macrophage for producing matrix metalloproteinase (MMP), prostaglandine E2 (PGE2), and pro-inflammatory cytokines such as IL-1, IL-6, and TNF-α. The administration of robusta coffee bean polyphenol extract was effective in reducing the degree of inflammation which was characterized by a decrease in TNF-α expression.…”

Section: Discussionmentioning

confidence: 99%

Anti–Peri-implantitis Bacteria's Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study

et al. 2022

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Objective This study was aimed to investigate RGCBE extract as antioxidant and anti–peri-implantitis bacteria through in vitro study and its potential as antioxidant, antibacterial, anti-inflammatory, antibone resorption, and proosteogenic through in silico study. Materials and Methods Absorption, distribution, metabolism, excretion and toxicity prediction, molecular docking simulation, and visualization of chlorogenic acid (CGA) and coumaric acid (CA) as anti-inflammatory, antioxidant, and antibacterial were investigated in silico. Inhibition zone by diffusion method, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) of RGCBE extract against Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Fusobacterium nucleatum (Fn), and Prevotella intermedia (Pi) were done. Statistical Analysis the analysis of variance (ANOVA) difference test, and the post-hoc Tukey's Honest Significant Different (HSD) with a different significance value of p<0.05 Results GCA and CA compounds are good drug molecules and it has low toxicity. Chlorogenic acid have higher binding activity than coumaric acid to tumor necrosis factor (TNF)-α, nuclear factor (NF)-κB, receptor activation NF-κB (RANK) and its ligand (RANKL), interleukin (IL)-6, IL-10, runt related transcription factor (RUNX2), receptor activator nuclear Kappa beta Ligand-osteoprotegrin osteocalcin (RANKL-OPG), osteocalcin, nuclear factor associated T-cell 1 (NFATc1), tartate resistant acid phosphatase (TRAP), peptidoglycan, flagellin, dectin, Hsp70, and Hsp10 protein. RGCB ethanol extract has high antioxidant ability and it has MIC, MBC, and inhibit the growth of Aa, Pg, Fn, and Pi at 50% concentration with significantly different (p=0.0001 and<0.05). Conclusion RGCB ethanol extract has high antioxidant ability and 50% RGCB ethanol extract may act as strong anti–peri-implantitis bacteria in vitro. In addition, CGA in RGCB potential as antioxidant, antibacterial, anti-inflammatory, antibone resorption, and proosteogenic in silico.

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“…TNF-a memiliki peran utama pada reaksi inflamasi, resorpsi tulang alveolar dan hilangnya perlekatan pada jaringan ikat. Prostaglandin dan sitokin proinflamasi juga dapat menghasilkan reactive oxygen species (ROS) menyebabkan terjadinya resopsi tulang alveolar dengen menstimulasi pembentukan osteoklas dan peningkatan pada aktivitasnya (Fatimatuzzahro et al, 2020) Pemberian Ozonated olive oil yang diaplikasikan dengan topikal dapat meningkatkan jumlah osteoblas tulang alveolar, pembuluh darah dalam proses penyembuhan periodontitis (Herawati et al, 2020). Ozonated olive oil sendiri merupakan minyak zaitun murni yang telah mengalami ozonasi menggunakan aliran campuran ozon-oksigen dengan perbandingan 5: 95%.…”

Section: Hasilunclassified

Pengaruh Ozonated Olive Oil terhadap Jumlah Osteoblas pada Gingiva Tikus Wistar Jantan yang Mengalami Periodontitis

Anwaristi,

Arifin

2023

phms

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Latar Belakang: Periodontitis disebabkan adanya penumpukan bakteri plak pada permukaan gigi. Pengobatan pada penyakit periodontitis secara mekanis juga harus menggunakan pengobatan kimiawi lokal yang diutamakan dibanding pengobatan sistemik seperti antibiotik. Ozonated olive oil sebagai terapi tambahan tidak menimbulkan rasa sakit dan dapat digunakan sebagai antiseptik dalam perawatan non-bedah penyakit periodontal. Ozon juga memiliki spektrum aktivitas yang luas tetapi dengan toksisitas rendah, memberikan keuntungan pada perawatan lokal ini sebelum pengembangan zat dengan aksi yang lebih spesifik pada mikro- organisme yang terkait dengan periodontitis. Metode: Penelitian ini merupakan jenis penelitian true experimental laboratorium dengan rancangan penelitian Posttest-Only Control Group dan terdapat dua kelompok kontrol yaitu, kelompok kontrol dan kelompok perlakuan. sampel terdiri atas 24 tikus wistar jantan diinkubasi periodontitis dibagi menjadi 2 kelompok berdasarkan hari, kelompok kontrol dan kelompok perlakuan. sampel dianalisis secara histologis pada hari ke- 7 dan 14. Hasil: Hasil uji hipotesis menemukan bahwa nilai signifikansi p 0,00 (p<0,05), hasil tersebut menunjukkan bahwa terdapat perbedaan yang signifikan jumlah sel osteoblas antara kelompok perlakuan ozonated olive oil dengan kelompok kontrol. Hasil Uji Post Hoc LSD menunjukkan bahwa kelompok perlakuan memiliki perbedaan bermakna antara kelompok kontrol dan perlakuan memiliki tingkat signifikansi (p<0,05). Kesimpulan: Penelitian yang telah dilakukan menghasilkan kesimpulan bahwa pemberian ozonated olive oil dapat mempengaruhi jumlah sel osteoblas berperan dalam proses penyembuhan periodontitis pada tikus putih (rattus novergicus) galur wistar jantan.

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Abstract: Efek pemberian gel ekstrak biji kopi robusta (Coffea canephora) terhadap jumlah osteoblas dan osteoklas (Destianingrum dkk.

Cited by 5 publications

References 18 publications

Accelerating Wound Healing of Traumatic Ulcer with Topical Application of Dental Pulp Mesenchymal Stem Cell Secretome and Robusta Green Coffee Bean Extract Combination in vivo

Accelerating Wound Healing of Traumatic Ulcer with Topical Application of Dental Pulp Mesenchymal Stem Cell Secretome and Robusta Green Coffee Bean Extract Combination in vivo

Anti–Peri-implantitis Bacteria's Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study

Pengaruh Ozonated Olive Oil terhadap Jumlah Osteoblas pada Gingiva Tikus Wistar Jantan yang Mengalami Periodontitis

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