2020
DOI: 10.2147/idr.s248091
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<p>Emergence of <em>bla</em><sub>NDM-1</sub> Harboring <em>Klebsiella pneumoniae</em> ST29 and ST11 in Veterinary Settings and Waste of Pakistan</p>

Abstract: Introduction: Intense livestock farming practices enforcing the farmers to use antibiotics as food supplements on a routine basis. Aberrant use of antibiotics is associated with the emergence of antibiotics resistance and resistant superbugs. Keeping in view the current scenario, the present study was designed for the first time from Pakistan with a specific aim to estimate the prevalence of the carbapenem-resistant Klebsiella pneumoniae in veterinary settings and the waste in Pakistan. Methods: A total of 138… Show more

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Cited by 25 publications
(34 citation statements)
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“…All isolates were susceptible to the carbapenems meropenem and imipenem. Studies from Asia and Africa report high levels of carbapenem-resistant Enterobacterales [ 23 , 24 ]. These findings are not surprising, since carbapenems are not approved for use in livestock in the European Union (EU) and similar results have been reported by others (reviewed in [ 25 ]).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…All isolates were susceptible to the carbapenems meropenem and imipenem. Studies from Asia and Africa report high levels of carbapenem-resistant Enterobacterales [ 23 , 24 ]. These findings are not surprising, since carbapenems are not approved for use in livestock in the European Union (EU) and similar results have been reported by others (reviewed in [ 25 ]).…”
Section: Discussionmentioning
confidence: 99%
“…Sequence type 29 has already been identified in K. pneumoniae in several studies in different regions of the world in samples of animal origin. These include slaughterhouse effluents in Pakistan [ 23 ] and poultry meat imported from the Netherlands in Ghana [ 24 ]. In the Pakistan study, nearly 10% of K. pneumoniae isolates were carbapenem-resistant, and ST29 accounted for over 50%.…”
Section: Discussionmentioning
confidence: 99%
“…The minimum inhibitory concentration (MIC) of antibiotics was estimated by the broth microdilution assay as described earlier (9). Briefly, 0.5 McFarland standards were prepared using freshly grown K. pneumoniae.…”
Section: Broth Microdilution Assaymentioning
confidence: 99%
“…The bacterial infections caused by this bacterium show a mounting ability to acquire resistance against various antibiotics (6,7). In fact, infections by MDR K. pneumoniae strains are increasing in health care settings worldwide (8,9). Prolonged hospitalization and high mortality rate are the common consequences of vari-ous infections caused by MDR K. pneumoniae (10).…”
Section: Introductionmentioning
confidence: 99%
“…As such, plasmids from this incompatibility group constitute a threat to public health and animal welfare. Of significance, Salmonella spp., E. coli , Klebsiella pneumoniae , and Enterobacter cloacae have all been identified as carriers of IncHI2 plasmids ( Wong et al, 2016 ; Matamoros et al, 2017 ; Zhao et al, 2018 ; Chaudhry et al, 2020 ). Gene operons encoding metal resistances, such as tellurium ( terZABCDE / Y3Y2XY1W ), mercury ( merRTPCADE ), copper ( pcoABCDRSE ), and silver ( silESRCBAP ) are also common-place in this plasmid family ( Fang et al, 2016 ).…”
Section: Introductionmentioning
confidence: 99%