&lt;p&gt;Glucose-responsive mesoporous silica nanoparticles to generation of hydrogen peroxide for synergistic cancer starvation and chemistry therapy&lt;/p&gt;

Du, Xiao; Tian, Zhang; Ma, Guanglan; Gu, Xiaochen; Wang, Guangji; Li, Juan

doi:10.2147/ijn.s195900

Cited by 43 publications

(14 citation statements)

References 39 publications

(52 reference statements)

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“…For example, the group of Gu has pioneered the use of microneedle devices for insulin delivery. , In the field of oncology, glucose-responsive materials have additionally seen use. Cancer starvation therapies (and starvation plus chemotherapeutic combination therapies) have been investigated by researchers as a glucose-responsive cancer treatment strategy. − The responsive units of PBA and GOx have also been widely implemented in various clinically approved and pre-clinical electrochemical, fluorometric, and flow-based biosensors for use in point-of-care continuous glucose monitoring devices. , …”

Section: Glucosementioning

confidence: 99%

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

2021

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Materials that respond to endogenous stimuli are being leveraged to enhance spatiotemporal control in a range of biomedical applications from drug delivery to diagnostic tools. The design of materials that undergo morphological or chemical changes in response to specific biological cues or pathologies will be an important area of research for improving efficacies of existing therapies and imaging agents, while also being promising for developing personalized theranostic systems. Internal stimuli-responsive systems can be engineered across length scales from nanometers to macroscopic and can respond to endogenous signals such as enzymes, pH, glucose, ATP, hypoxia, redox signals, and nucleic acids by incorporating synthetic bio-inspired moieties or natural building blocks. This Review will summarize response mechanisms and fabrication strategies used in internal stimuli-responsive materials with a focus on drug delivery and imaging for a broad range of pathologies, including cancer, diabetes, vascular disorders, inflammation, and microbial infections. We will also discuss observed challenges, future research directions, and clinical translation aspects of these responsive materials.

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Section: Glucosementioning

confidence: 99%

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

2021

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“…Thus, nanoformulation showed a promising H 2 O 2 -NO combined anticancer effect with minimal toxic side-effect. Similarly, hyaluronic acid (HA) coated glucose-responsive MSN have been demonstrated for co-delivery of GOx and anticancer drug paclitaxel [ 65 ]. In comparison to single chemotherapy, co-delivery with GOx revealed enhanced therapeutic effect by interrupting the energy supply in the cells, due to consumption of intratumoral glucose which raised the toxic endogenous H 2 O 2 level.…”

Section: Stimuli Responsive Intelligent Nanomaterials In Cancer Thera...mentioning

confidence: 99%

Smart nanomaterials for cancer diagnosis and treatment

et al. 2022

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Innovations in nanomedicine has guided the improved outcomes for cancer diagnosis and therapy. However, frequent use of nanomaterials remains challenging due to specific limitations like non-targeted distribution causing low signal-to-noise ratio for diagnostics, complex fabrication, reduced-biocompatibility, decreased photostability, and systemic toxicity of nanomaterials within the body. Thus, better nanomaterial-systems with controlled physicochemical and biological properties, form the need of the hour. In this context, smart nanomaterials serve as promising solution, as they can be activated under specific exogenous or endogenous stimuli such as pH, temperature, enzymes, or a particular biological molecule. The properties of smart nanomaterials make them ideal candidates for various applications like biosensors, controlled drug release, and treatment of various diseases. Recently, smart nanomaterial-based cancer theranostic approaches have been developed, and they are displaying better selectivity and sensitivity with reduced side-effects in comparison to conventional methods. In cancer therapy, the smart nanomaterials-system only activates in response to tumor microenvironment (TME) and remains in deactivated state in normal cells, which further reduces the side-effects and systemic toxicities. Thus, the present review aims to describe the stimulus-based classification of smart nanomaterials, tumor microenvironment-responsive behaviour, and their up-to-date applications in cancer theranostics. Besides, present review addresses the development of various smart nanomaterials and their advantages for diagnosing and treating cancer. Here, we also discuss about the drug targeting and sustained drug release from nanocarriers, and different types of nanomaterials which have been engineered for this intent. Additionally, the present challenges and prospects of nanomaterials in effective cancer diagnosis and therapeutics have been discussed.

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“…MSN-based nanostructures can be triggered via NIR light [558], US [559], magnetic fields [560,561], electricity [562], or temperature [563] as examples of exogenous stimuli. Redox potential [564,565], pH changes [566], enzyme activity [567], glucose [568], and ATP [569] concentrations are examples of endogenous stimuli. Stimulusresponsive silica nanostructures have been reviewed in [570][571][572].…”

Section: Silica Nanostructuresmentioning

confidence: 99%

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

Fateh¹,

Moradi²,

Kohan³

et al. 2021

Beilstein J. Nanotechnol.

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The field of theranostics has been rapidly growing in recent years and nanotechnology has played a major role in this growth. Nanomaterials can be constructed to respond to a variety of different stimuli which can be internal (enzyme activity, redox potential, pH changes, temperature changes) or external (light, heat, magnetic fields, ultrasound). Theranostic nanomaterials can respond by producing an imaging signal and/or a therapeutic effect, which frequently involves cell death. Since ultrasound (US) is already well established as a clinical imaging modality, it is attractive to combine it with rationally designed nanoparticles for theranostics. The mechanisms of US interactions include cavitation microbubbles (MBs), acoustic droplet vaporization, acoustic radiation force, localized thermal effects, reactive oxygen species generation, sonoluminescence, and sonoporation. These effects can result in the release of encapsulated drugs or genes at the site of interest as well as cell death and considerable image enhancement. The present review discusses US-responsive theranostic nanomaterials under the following categories: MBs, micelles, liposomes (conventional and echogenic), niosomes, nanoemulsions, polymeric nanoparticles, chitosan nanocapsules, dendrimers, hydrogels, nanogels, gold nanoparticles, titania nanostructures, carbon nanostructures, mesoporous silica nanoparticles, fuel-free nano/micromotors.

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<p>Glucose-responsive mesoporous silica nanoparticles to generation of hydrogen peroxide for synergistic cancer starvation and chemistry therapy</p>

Cited by 43 publications

References 39 publications

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

Smart nanomaterials for cancer diagnosis and treatment

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

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