&lt;p&gt;Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits&lt;/p&gt;

Zhao, Baodong; Li, Xin; Xu, Hao; Jiang, Yaping; Wang, Dashan; Liu, Ran

doi:10.2147/ijn.s244815

Cited by 24 publications

(16 citation statements)

References 34 publications

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“…So far, several in vitro studies on animal models have been developed to test the effectiveness of strontium-enriched hydroxyapatite bioceramics [ 63 , 64 , 65 , 66 ]. Research has confirmed the therapeutic potential of such materials, indicating their effectiveness in the regeneration of bone tissue, high biocompatibility, and improvement of osteogenic abilities.…”

Section: Strontium In the Treatment Of Osteoporosismentioning

confidence: 99%

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

Kołodziejska

Stępień

Kolmas

2021

IJMS

166

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Osteoporosis is a chronic disease characterized by low bone mass caused by increased bone turnover and impaired bone microarchitecture. In treatment, we use antiresorptive or anabolic drugs, which usually have a unidirectional effect, i.e., they inhibit the activity of osteoclasts or stimulate the effect of osteoblasts. Strontium ranelate is an anti-osteoporosis drug with a unique mechanism of action (used primarily in postmenopausal women). Unlike other medicines, it has a multidirectional effect on bone tissue, intensifying osteoblastogenesis while inhibiting osteoclastogenesis. It turns out that this effect is demonstrated by strontium ions, an element showing physical and chemical similarity to calcium, the basic element that builds the mineral fraction of bone. As a result, strontium acts through the calcium-sensing receptor (CaSR) receptor in bone tissue cells. In recent years, there has been a significant increase in interest in the introduction of strontium ions in place of calcium ions in ceramics used as bone replacement materials for the treatment of bone fractures and defects caused by osteoporosis. The aim of this study was to summarize current knowledge about the role of strontium in the treatment of osteoporosis, its effects (in various forms), and the ways in which it is administered.

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Section: Strontium In the Treatment Of Osteoporosismentioning

confidence: 99%

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

Kołodziejska

Stępień

Kolmas

2021

IJMS

166

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“…The contact angle was lower when coating with GoHAP3 compared to GoHAP1. The results are important for biomedical applications, as the reduced water contact angle contributes to improved cell attachment, bone growth and bioactivity [66][67][68]. Values are given as mean ± SD.…”

Section: Contact Angle Measurement Of Coatingsmentioning

confidence: 99%

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

et al. 2021

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Medical implant use is associated with a risk of infection caused by bacteria on their surface. Implants with a surface that has both bone growth-promoting properties and antibacterial properties are of interest in orthopedics. In the current study, we fabricated a bioactive coating of hydroxyapatite nanoparticles on polyether ether ketone (PEEK) using the sonocoating method. The sonocoating method creates a layer by immersing the object in a suspension of nanoparticles in water and applying a high-power ultrasound. We show that the simple layer fabrication method results in a well-adhering layer with a thickness of 219 nm to 764 nm. Dropping cefuroxime sodium salt (Cef) antibiotic on the coated substrate creates a layer with a drug release effect and antibacterial activity against Staphylococcus aureus. We achieved a concentration of up to 1 mg of drug per cm2 of the coated substrate. In drug release tests, an initial burst was observed within 24 h, accompanied by a linear stable release effect. The drug-loaded implants exhibited sufficient activity against S. aureus for 24 and 168 h. Thus, the simple method we present here produces a biocompatible coating that can be soaked with antibiotics for antibacterial properties and can be used for a range of medical implants.

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“…Recently, it is demonstrated that MAO results in the formation of a porous oxide layer on implant surfaces, further enhancing biocompatibility and bonding strength [ 16 ]. Furthermore, by adjusting the electrolyte compositions, various metal ion-doped coatings can be successfully constructed onto implant surfaces [ 17 ]. Various metal ions ( e.g.…”

Section: Introductionmentioning

confidence: 99%

High proportion strontium-doped micro-arc oxidation coatings enhance early osseointegration of titanium in osteoporosis by anti-oxidative stress pathway

Shen

Fang

Yie

et al. 2022

Bioactive Materials

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The excessive accumulation of reactive oxygen species (ROS) under osteoporosis precipitates a microenvironment with high levels of oxidative stress (OS). This could significantly interfere with the bioactivity of conventional titanium implants, impeding their early osseointegration with bone. We have prepared a series of strontium (Sr)-doped titanium implants via micro-arc oxidation (MAO) to verify their efficacy and differences in osteoinduction capabilities under normal and osteoporotic (high OS levels) conditions. Apart from the chemical composition, all groups exhibited similar physicochemical properties (morphology, roughness, crystal structure, and wettability). Among the groups, the low Sr group (Sr25%) was more conducive to osteogenesis under normal conditions. In contrast, by increasing the catalase (CAT)/superoxide dismutase (SOD) activity and decreasing ROS levels, the high Sr-doped samples (Sr75% and Sr100%) were superior to Sr25% in inducing osteogenic differentiation of MC3T3-E1 cells and the M2 phenotype polarization of RAW264.7 cells, thus enhancing early osseointegration. Furthermore, the results of both in vitro cell co-culture and in vivo studies also showed that the high Sr-doped samples (especially Sr100%) had positive effects on osteoimmunomodulation under the OS microenvironment. Ultimately, the collated findings indicated that the high proportion Sr-doped MAO coatings were more favorable for osteoporosis patients in implant restorations.

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<p>Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits</p>

Cited by 24 publications

References 34 publications

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

High proportion strontium-doped micro-arc oxidation coatings enhance early osseointegration of titanium in osteoporosis by anti-oxidative stress pathway

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