&lt;p&gt;Nanoscale 3D Bioprinting for Osseous Tissue Manufacturing&lt;/p&gt;

Wang, Yujia; Gao, Ming; Wang, Danquan; Sun, Linlin; Webster, Thomas J.

doi:10.2147/ijn.s172916

Cited by 24 publications

(9 citation statements)

References 84 publications

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“…Yet, due to the novelty of this niche market, no bioprinter reviews that we could find focus on the latest commercially available low-cost systems. Specifically, the previously published reviews either give an overview of the entire bioprinting field (with a focus on the evolution of the printing technologies), 9–13 review bio-inks, 14–27 or discuss specific applications (e.g., cardiovascular tissue models, 14,28–35 bone tissue models, 36–48 cartilage tissue models, 42,47,49–52 nerve tissue models, 53–61 skin tissue models, 48,62–66 and in vivo bioprinting 67–…”

Section: Introductionmentioning

confidence: 99%

Review of Low-Cost 3D Bioprinters: State of the Market and Observed Future Trends

et al. 2021

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Three-dimensional (3D) bioprinting has become mainstream for precise and repeatable high-throughput fabrication of complex cell cultures and tissue constructs in drug testing and regenerative medicine, food products, dental and medical implants, biosensors, and so forth. Due to this tremendous growth in demand, an overwhelming amount of hardware manufacturers have recently flooded the market with different types of low-cost bioprinter models—a price segment that is most affordable to typical-sized laboratories. These machines range in sophistication, type of the underlying printing technology, and possible add-ons/features, which makes the selection process rather daunting (especially for a nonexpert customer). Yet, the review articles available in the literature mostly focus on the technical aspects of the printer technologies under development, as opposed to explaining the differences in what is already on the market. In contrast, this paper provides a snapshot of the fast-evolving low-cost bioprinter niche, as well as reputation profiles (relevant to delivery time, part quality, adherence to specifications, warranty, maintenance, etc.) of the companies selling these machines. Specifically, models spanning three dominant technologies—microextrusion, droplet-based/inkjet, and light-based/crosslinking—are reviewed. Additionally, representative examples of high-end competitors (including up-and-coming microfluidics-based bioprinters) are discussed to highlight their major differences and advantages relative to the low-cost models. Finally, forecasts are made based on the trends observed during this survey, as to the anticipated trickling down of the high-end technologies to the low-cost printers. Overall, this paper provides insight for guiding buyers on a limited budget toward making informed purchasing decisions in this fast-paced market.

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Section: Introductionmentioning

confidence: 99%

Review of Low-Cost 3D Bioprinters: State of the Market and Observed Future Trends

et al. 2021

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“…This was followed by the development of biomaterial direct printing into 3D frameworks using solvent-free, aqueous-based systems, which enabled transplantation with or without seeded cells [ 11 ]. Recent progress in nanotechnology, cell biology, and materials science has made it possible for 3D bioprinting to be used as a method for improved tissue engineering, which presents tremendous potential for more future advancements in medicine [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

3D Bioprinting in Tissue Engineering for Medical Applications: The Classic and the Hybrid

et al. 2020

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Three-dimensional (3D) printing, as one of the most popular recent additive manufacturing processes, has shown strong potential for the fabrication of biostructures in the field of tissue engineering, most notably for bones, orthopedic tissues, and associated organs. Desirable biological, structural, and mechanical properties can be achieved for 3D-printed constructs with a proper selection of biomaterials and compatible bioprinting methods, possibly even while combining additive and conventional manufacturing (AM and CM) procedures. However, challenges remain in the need for improved printing resolution (especially at the nanometer level), speed, and biomaterial compatibilities, and a broader range of suitable 3D-printed materials. This review provides an overview of recent advances in the development of 3D bioprinting techniques, particularly new hybrid 3D bioprinting technologies for combining the strengths of both AM and CM, along with a comprehensive set of material selection principles, promising medical applications, and limitations and future prospects.

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“…35 Furthermore, its inherent capability for reproducibility, accuracy and customization of scaffolds make 3D-printing a promising and innovative biofabrication strategy in bone tissue engineering. [36][37][38][39] In addition, compared with conventional materials, nanoscale materials may be more efficient materials at stimulating new bone formation due to large specific surface area ratios and special topological conformation, which influence cellular differentiation and functions. 36,38,40,41 By combining 3D-printing, nanotechnology, and materials science, bone tissue engineering exhibits enormous prospects for future development.…”

Section: Introductionmentioning

confidence: 99%

<p>A Novel 3D-bioprinted Porous Nano Attapulgite Scaffolds with Good Performance for Bone Regeneration</p>

Wang

Hui

Zhao

et al. 2020

IJN

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Background: Natural clay nanomaterials are an emerging class of biomaterial with great potential for tissue engineering and regenerative medicine applications, most notably for osteogenesis. Materials and Methods: Herein, for the first time, novel tissue engineering scaffolds were prepared by 3D bioprinter using nontoxic and bioactive natural attapulgite (ATP) nanorods as starting materials, with polyvinyl alcohol as binder, and then sintered to obtain final scaffolds. The microscopic morphology and structure of ATP particles and scaffolds were observed by transmission electron microscope and scanning electron microscope. In vitro biocompatibility and osteogenesis with osteogenic precursor cell (hBMSCs) were assayed using MTT method, Live/Dead cell staining, alizarin red staining and RT-PCR. In vivo bone regeneration was evaluated with micro-CT and histology analysis in rat cranium defect model. Results: We successfully printed a novel porous nano-ATP scaffold designed with inner channels with a dimension of 500 µm and wall structures with a thickness of 330 µm. The porosity of current 3D-printed scaffolds ranges from 75% to 82% and the longitudinal compressive strength was up to 4.32±0.52 MPa. We found firstly that nano-ATP scaffolds with excellent biocompatibility for hBMSCscould upregulate the expression of osteogenesisrelated genes bmp2 and runx2 and calcium deposits in vitro. Interestingly, micro-CT and histology analysis revealed abundant newly formed bone was observed along the defect margin, even above and within the 3D bioprinted porous ATP scaffolds in a rat cranial defect model. Furthermore, histology analysis demonstrated that bone was formed directly following a process similar to membranous ossification without any intermediate cartilage formation and that many newly formed blood vessels are within the pores of 3D-printed scaffolds at four and eight weeks. Conclusion: These results suggest that the 3D-printed porous nano-ATP scaffolds are promising candidates for bone tissue engineering by osteogenesis and angiogenesis.

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<p>Nanoscale 3D Bioprinting for Osseous Tissue Manufacturing</p>

Cited by 24 publications

References 84 publications

Review of Low-Cost 3D Bioprinters: State of the Market and Observed Future Trends

Review of Low-Cost 3D Bioprinters: State of the Market and Observed Future Trends

3D Bioprinting in Tissue Engineering for Medical Applications: The Classic and the Hybrid

<p>A Novel 3D-bioprinted Porous Nano Attapulgite Scaffolds with Good Performance for Bone Regeneration</p>

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