<p>Simvastatin improves the eradication rate of <em>Helicobacter pylori</em>: upper Egypt experience</p>

Abstract

Background: Helicobacter pylori infection is one of the most prevalent chronic bacterial human infections worldwide. Helicobacter pylori colonizes the gastric mucosa and causes persistent gastritis that may progress to gastric cancer. Increased resistance of H. pylori presents a major problem in most countries. Statins, including simvastatin, which are currently used to treat hypercholesterolemia, appear to have potential synergistic role to antibiotics. This study aimed to assess the value of adding simvastatin as adjuvant to standard triple therapy in patients infected with H. pylori . Methods: This study was conducted on 100 patients diagnosed with H. pylori by the presence of antigen in stools. All patients were randomly subjected either to the standard triple regimen (clarithromycin 500 mg bid + amoxicillin 1 g bid + omeprazole 20 mg bid) (group 1, N=50) or to the standard triple regimen plus simvastatin (clarithromycin 500 mg bid + amoxicillin 1 g bid + omeprazole 20 mg bid + simvastatin 20 mg bid) (group 2, N=50). Both groups were treated for 14 days and eradication of H. pylori was assessed by a stool antigen test 4 weeks after therapy. Results: Eradication of H. pylori infection was significantly higher in patients treated with the standard triple therapy plus simvastatin (n=41, 82%) than in patients treated with the standard triple therapy (n=31, 62%) ( P <0.022). Conclusion: Simvastatin significantly improves the H. pylori eradication rate.

The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)

“…Only in the standard triple therapy was the use of these drugs associated with lower effectiveness. This finding is opposed to what was described in the randomized studies of Nseir and Hassan, in which the addition of simvastatin 20 mg twice daily to the standard triple therapy containing clarithromycin and amoxicillin showed a statistically significant increase in effectiveness of 15–20% [ 26 , 35 ]. Despite their findings, several voices questioned whether this hypothetical increase would be clinically significant considering the unacceptable effectiveness rate reported for the standard triple therapy over the years in most geographical areas [ 1 , 6 , 36 ].…”

Eradication of Helicobacter Pylori with Triple Therapy Comprising Probiotic & Proton Pump Inhibitor

“…The test showed insignificant mean difference in both the groups at baseline and after 14 days and the p-value was also found to be insignificant between both the groups (0.741). A former study conducted by Hassan et al, 2019 also showed no significant change between the two groups before and after treatment [20]. similar results was also showed by [21].…”

Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

“…Also, depletion of cholesterol has been demonstrated to attenuate CagA-induced pathogenesis [ 59 ]. Adding statin to the standard triple therapy may improve the eradication rate of HP infection [ 60 ].…”