<p>Treatment of recurrent myopic macular hole using membrane of plasma rich in growth factors</p>

Abstract

Purpose To describe the case of a patient with a recurrent large myopic macular hole (MH), who was successfully treated with a plasma rich in growth factors (PRGF) membrane. Case Report A 71-year-old patient presented a myopic MH in his right eye. One month later, pars plana vitrectomy with internal limiting membrane (ILM) peeling was performed, achieving closure of the MH. Three months later a recurrence was observed (700 µm) without visual acuity (VA) improvement. A new surgery was carried out placing an autologous PRGF-membrane into the MH, and performing a fluid-gas exchange at the end of the surgery. After two months of follow-up, the MH was completely closed, obtaining the anatomic recovery of the foveal depression, and improving the VA to 0.1. No adverse reactions were associated with the use of PRGF and there were no new recurrences of the MH in a follow-up period of six months. Conclusion The use of PRGF-membrane can be used as adjunctive therapy in the surgical repair of recurrent large myopic MHs, thus improving anatomic and visual outcomes.

Antioxidant Role of PRGF on RPE Cells after Blue Light Insult as a Therapy for Neurodegenerative Diseases

“…In addition, it is also involved in eye hydration [37] and reducing inflammation. Previous research has shown the retina responds well to PRGF treatment [38]. Therefore, the inherent features of PRGF suggest that it could act as an antioxidant agent.…”

Plasma Rich in Growth Factors in Macular Hole Surgery

“…Since the 1990s, blood derivatives (autologous serum, autologous platelet concentrates (APC) or also called platelet rich plasma (PRP)) have been used classically as an adjuvant therapy to increase the rate of closure in MHs [ 14 , 34 ]. More recently, biological tissues have been used as scaffolding with the ability to release growth factors, including human amniotic membrane (hAM) [ 35 ], fibrin rich plasma [ 36 ], and PRGF [ 23 , 37 ].…”

“…PRGF has demonstrated anti-inflammatory, anti-fibrotic, and regenerative functions in ocular surface and cornea diseases (dry eye, persistent epithelial defects, neurotrophic keratitis, among others) [ 19 , 20 , 21 , 22 ]. The use of the PRGF membrane in the closure of MH in high myopia has also achieved good anatomical and visual results [ 23 ].…”

Plasma Rich in Growth Factors Enhances Cell Survival after in Situ Retinal Degeneration

“…In ophthalmology, it has been used for treating eye surface disorders such as PED or dry eye [ 25 , 27 , 28 , 29 , 31 , 47 , 49 ]. In terms of pathologies related to the retina, PRGF has also been used to treat macular holes, producing good results in both anatomical closure and vision recovery [ 32 , 33 ]. Other experimental studies demonstrated the neuroprotector role of PRGF in the retina.…”

“…It has been widely used in oral implantology and traumatology, and in ophthalmology for treating ocular surface diseases, such as persistent epithelial defects (PEDs) [ 25 , 26 , 27 , 28 , 29 ], conjunctivitis, or other ocular surface pathologies [ 30 , 31 ]. In the retina, PRGF has been proven to reduce macular holes [ 32 , 33 ]. Our group previously tested its effect on retinal pigment epithelium (RPE) through the reduction in the harm produced by oxidative stress.…”