&lt;p&gt;tRNA-derived fragment tRF-03357 promotes cell proliferation, migration and invasion in high-grade serous ovarian cancer&lt;/p&gt;

Zhang, Minmin; Li, Feifei; Wang, Jing; He, Wenzhu; Li, Yun; Li, Hongyan; Wei, Zhaolian; Cao, Yunxia

doi:10.2147/ott.s206861

Cited by 89 publications

(98 citation statements)

References 34 publications

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“…tsRNAs were veri ed to be associated with numerous diseases, such as metabolic disorder, pathological stress injuries, neurodegenerative diseases, virus infection as well as cancer (9). In elds related to cancer research, expression pro le and biological function of tsRNAs were reported in chronic lymphocytic leukemia (CLL) (10,11), lung cancer (5,10,12), colorectal cancer (5, 13), breast cancer (5, 14-17), ovarian cancer (5,18,19) and prostate cancer (20,21). However, tsRNAs have not been elucidated in PDAC.…”

Section: Introductionmentioning

confidence: 99%

Serum tRNA-derived small RNAs as potential novel diagnostic biomarkers for Pancreatic Ductal Adenocarcinoma

Xue

Shi

Xie

et al. 2020

Preprint

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Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal common cancer because of late diagnosis. tRNA-derived small RNAs (tsRNAs) are novel small RNAs might serve as biomarkers for cancer diagnosis and participate in diverse physiological and pathological process. We investigated whether the expression of tsRNAs in serum could be a noninvasive method in the early diagnosis of PDAC.Methods Blood sample of PDAC patients and healthy controls were collected from Ruijin Hospital, Shanghai, China. Tumor and adjacent normal pancreas tissues were collected from 51 patients with PDAC undergoing therapeutic surgery. The testing cohort comprised 6 PDAC patients and 6 healthy controls and the expression of small RNAs in serum was analyzed by small RNA sequence. We verified the diagnostic performance of serum tsRNAs by qPCR in validation cohort including 110 PDAC patients and 100 healthy controls. Expression level of tsRNAs in tissue was also verified in another independent cohort including 51 tumor and 51 adjacent normal pancreas tissues. Unpaired t-test and paired t-test are used for comparing depending on whether the samples are paired. Receiver operating characteristic (ROC) area under the curve (AUC) was used to determine diagnostic accuracy.Results There were 45 tsRNAs expressed at remarkably higher levels, 6 tsRNAs expressed at lower levels in PDAC patients, respectively, compared with healthy volunteers. tsRNA-ValTAC-41, tsRNA-MetCAT-37 and tsRNA-ThrTGT-23 expressed significant highly (P<0.05) in serum of PDAC patients in validation cohort. tsRNA-ValTAC-41 or tsRNA-MetCAT-37 combined with CA19-9 could increase the AUC of PDAC prediction (AUC=0.947 and 0.949 respectively), relative to CA19-9 test alone. Besides, tsRNA-ValTAC-41 expressed at remarkably higher level in tumor tissue, and it was obviously associated with tumor staging both in serum and tissue.Conclusions We provide tsRNAs profiles observed by small RNA sequencing. The diagnostic accuracy of tsRNA-ValTAC-41 and tsRNA-MetCAT-37 in serum of PDAC patients were verified. Further studies for tsRNA-ValTAC-41 are needed to confirm the findings. These tsRNAs may be promising and effective candidates in the development of highly sensitive, noninvasive biomarkers for PDAC diagnosis.

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Section: Introductionmentioning

confidence: 99%

Serum tRNA-derived small RNAs as potential novel diagnostic biomarkers for Pancreatic Ductal Adenocarcinoma

Xue

Shi

Xie

et al. 2020

Preprint

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“…Zhang et al, reported that tRFs were involved in cell transcription, migration, and interaction with the MAPK and Wnt signaling pathways. Moreover, tRF-03357 was predictively targeted, due to promoting cell proliferation, migration, and invasion [55].…”

Section: Ovarian Cancermentioning

confidence: 99%

Dynamic Signature of tRNA-Derived small RNAs in Cancer Pathogenesis as a Promising Valuable Approach

Fattahi

Sahlolbei

Vafaei

et al. 2020

Preprint

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Background: Non-coding RNAs are a cluster of RNAs that do not encode functional proteins, and involve infrastructural and regulatory types, which transfer RNAs (tRNAs) belong to former and small RNAs (sRNA) to the latter one. Recently, tRNA-derived small RNAs (tDRs) were discovered among small non-coding RNA, as the newly discovered regulatory small RNA. It plays a role in pathological and physiological processes, which is frequently dysregulated in gene expression regulation. tsRNAs can be bounded to argonaute proteins and piwi proteins such as miRNAs and piRNAs sequentially. In addition, it can interact with DNA and histone methylation machinery Results: In initial searching, 2744 unique articles were identified by bio electronically search of following databases: PubMed, Embase, Web of Science, Scopus, and google scholar up to 25 February 2020. Finally, after Full-text assessment 48 related article to gene expression profiling tsRNA in cancer were achieved. Conclusions: In this systematic review, we summarized the most recent findings related to the expression of tsRNAs in 17 cancer types. We suggested that tsRNA in cancer field attracted the researchers' focus and effectively facilitated diagnostic and therapy approaches.

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“…For example, tsRNAs derived from tRNA(Glu), tRNA(Asp), tRNA(Gly), and tRNA(Tyr) suppress cancer cell growth and metastasis [ 16 ]. In contrast, tsRNA-26576 promotes breast cancer cell proliferation while inhibiting apoptosis [ 21 ], and tRF-03357 promotes ovarian cancer cell growth and migration [ 22 ]. In addition, tRF5-AlaCGC enhances the secretion of IL-8 in response to arsenite, via p65 activation [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

tRNA-Derived Small RNAs: Novel Epigenetic Regulators

Park

Ahn

Shin

et al. 2020

Cancers

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An epigenetic change is a heritable genetic alteration that does not involve any nucleotide changes. While the methylation of specific DNA regions such as CpG islands or histone modifications, including acetylation or methylation, have been investigated in detail, the role of small RNAs in epigenetic regulation is largely unknown. Among the many types of small RNAs, tRNA-derived small RNAs (tsRNAs) represent a class of noncoding small RNAs with multiple roles in diverse physiological processes, including neovascularization, sperm maturation, immune modulation, and stress response. Regarding these roles, several pioneering studies have revealed that dysregulated tsRNAs are associated with human diseases, such as systemic lupus, neurological disorder, metabolic disorder, and cancer. Moreover, recent findings suggest that tsRNAs regulate the expression of critical genes linked with these diseases by a variety of mechanisms, including epigenetic regulation. In this review, we will describe different classes of tsRNAs based on their biogenesis and will focus on their role in epigenetic regulation.

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<p>tRNA-derived fragment tRF-03357 promotes cell proliferation, migration and invasion in high-grade serous ovarian cancer</p>

Cited by 89 publications

References 34 publications

Serum tRNA-derived small RNAs as potential novel diagnostic biomarkers for Pancreatic Ductal Adenocarcinoma

Serum tRNA-derived small RNAs as potential novel diagnostic biomarkers for Pancreatic Ductal Adenocarcinoma

Dynamic Signature of tRNA-Derived small RNAs in Cancer Pathogenesis as a Promising Valuable Approach

tRNA-Derived Small RNAs: Novel Epigenetic Regulators

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