Lubeluzole inhibits accumulation of extracellular glutamate in the hippocampus during transient global cerebral ischemia

Beneficial effect of magnesium lithospermate B on cerebral ischemia–reperfusion injury in rats involves the regulation of miR-107/glutamate transporter 1 pathway

“…Among them, glutamate-induced neuronal toxicity, the so-called excitatory neurotoxicity, is thought as the triggering spark in the ischemic neuronal damage (Kostandy, 2012). Numerous studies have demonstrated that an accumulation of glutamate, the most abundant excitatory neurotransmitter in the brain, plays a major role in excitatory neurotoxicity following I/R, suggesting that a reduction of glutamate accumulation may have a potential value in prevention of cerebral I/R injury (Camacho and Massieu, 2006;Koinig et al, 2001).…”