Lung cancer in patients seropositive for human immunodeficiency virus.

Abstract

The authors describe the clinical and radiographic findings of lung carcinoma in six patients infected with the human immunodeficiency virus (HIV). These patients were in a younger age group than is commonly associated with lung cancer. The radiographic findings included mediastinal adenopathy (n = 5), hilar masses with distal atelectasis (n = 3), parenchymal masses (n = 3), pleural effusions (n = 2), and pleural thickening (n = 1). Recognition of any of these findings should raise the diagnostic possibility of lung cancer in this group of younger patients.

Carcinoma of the lung in HIV-positive patients: findings on chest radiographs and CT scans.

“…The present study was undertaken to provide a more complete description of the radiologic findings, particularly the role of CT, and to supplement the demographic data of HIV-positive patients with lung cancer reported previously. The clinical findings in our study of patients with HIV infection and lung cancer are similar to those of previous reports [3][4][5][6][7][8][9][10][11]. The median age of affected patients in our series (42 years) is much younger than patients with lung cancer in the general population, and the disease has a strong male predilection.…”

“…Moreover, two patients with isolated pleural thickening had bone metastases that were identified only on the CT scan (Fig. 2) in a radiologic publication [3], and no systematic study of the radiologic manifestations has been done. The present study was undertaken to provide a more complete description of the radiologic findings, particularly the role of CT, and to supplement the demographic data of HIV-positive patients with lung cancer reported previously.…”

Pulmonary Malignancies in the Immunocompromised Patient

“…Until 1990, the occurrence of BC in this setting was considered coincidental [216, 217, 218, 219]. In 1990, a first study found a 14-fold increase in the risk of lung cancer in 500 HIV-infected patients under 40 years of age [220]. Although the results of later studies were contradictory, most suggested that primary BC is more frequent in case of AIDS.…”

“…Their median age at diagnosis was 38–49 years [220, 224, 229, 230], compared to 60–70 among patients with BC in the general population. More than 60% of patients are intravenous drug users [223, 230], but homosexuals and bisexuals predominate in some series [221].…”

Computed tomography of the thorax in HIV disease

“…There are several reported series of lung carcinoma occurring in patients with AIDS [73,76,77,78,79,80]. It is not clear from these studies whether AIDS patients have an increased risk of developing primary malignant lung tumours.…”