Lung cancer risk of GSTM1 null genotype is dependent on the extent of tobacco smoke exposure

Kihara, Masahiro; Kihara, Masako; Noda, Kazumasa

doi:10.1093/carcin/15.2.415

Cited by 102 publications

(44 citation statements)

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“…This was observed for lung cancer where frequent smoking (Kihara et al, 1994) or low vitamin C consumption (Garcia-Closas et al, 1995) results in a higher cancer risk in the GSTM1 0 population than in the non-null population.…”

Section: Discussionmentioning

confidence: 88%

Allelotype influence at glutathione S-transferase M1 locus on breast cancer susceptibility

et al. 1998

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SummaryThe influence of polymorphisms of the glutathione S-transferase gene GSTM1 in breast cancer susceptibility has been assessed in this study. Previous studies correlated the absence of the GSTM1 protein with an increased risk of developing some cancers, especially lung or bladder cancers, in heavy smokers. In this study, we determined GSTM1 polymorphisms in a population of 437 female controls from the west of France and 361 community breast cancer patients. Three distinct alleles of this gene exist: GSTM1* A, GSTM1*B and GSTM1*0 (deleted allele). Null subjects (GSTM1 null) are homozygous for this deletion. The comparative analysis of GSTM1 allelotypes in our two populations did not demonstrate a statistically significant difference in distribution (P = 0.22), although the null genotype was more frequent in cancer patients. However, breast cancer risk was increased in null subjects ≥ 50 years of age compared with non-null subjects [odds ratio = 1.99 (1.19-3.32), P = 0.009], but not in null subjects < 50 years of age compared with non-null subjects (P = 0.86). Our results suggest that the GSTM1 null genotype may play a role in post-menopausal breast cancer development. They also point to a putative protective role of the A allele in the older female control group, especially in hemizygous subjects [odds ratio = 0.42 (0.23-0.77), P = 0.03].

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Section: Discussionmentioning

confidence: 88%

Allelotype influence at glutathione S-transferase M1 locus on breast cancer susceptibility

et al. 1998

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“…This direct effect has been shown in lung cancer patients with GSTM1- (Kihara et al, 1994) and PAH-albumin adducts (Autrup et al, 1995). These effects may be due to a more gene-environ-ment interactions at high levels of exposure to PAHs when CYP1A1 will be induced and there may not be enough GST enzymes to detoxify PAH derivatives.…”

Section: Discussionmentioning

confidence: 95%

Cytochrome P450 (CYP) and glutathione S-transferases (GST) polymorphisms (CYP1A1, CYP1B1, GSTM1, GSTP1 and GSTT1) and urinary levels of 1-hydroxypyrene in Turkish coke oven workers

et al. 2007

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Genetic polymorphisms of xenobiotic metabolizing enzymes have been associated with cancer risk. We evaluated the influences of genetic polymorphisms of polycyclic aromatic hydrocarbon (PAH) metabolizing enzymes on urinary 1-hydroxypyrene (1-OHP) excretion in Turkish coke oven workers. Urinary 1-OHP was analyzed by HPLC after enzymatic hydrolysis. Lymphocyte DNA was used for PCR-based genotyping of cytochrome P450 (CYP) polymorphisms (CYP1A1 and CYP1B1) and glutathione S-transferases (GST) polymorphisms (GSTM1, GSTT1 and GSTP1). The mean urinary 1-OHP levels of coke oven workers were significantly higher than that of controls. No significant difference was detected in the mean urinary 1-OHP levels of smokers and non-smokers either for coke oven workers or controls. Genetic polymorphisms of the CYPs and GSTs studied had no significant influence on 1-OHP excretion in coke oven workers, but in the control group the urinary 1-OHP levels of individuals carrying the GSTT1-genotype were significantly higher than those of individuals carrying GSTT1+ genotype. The duration of occupational exposure and metabolic genotype for GSTT1 were the significant predictors of urinary 1-OHP levels. The control individuals carrying combined GSTM1-/GSTT1-genotypes also had significantly higher levels of urinary 1-OHP than those of individuals carrying GSTM1+/GSTTI+, GSTM1-/GSTT1+, and GSTM1+/GSTT1-genotypes. These results indicate that urinary 1-OHP is a sensitive indicator of recent human exposure to PAHs and that genetic polymorphism of GSTT1 may also to some extent reflect the interindividual variation in susceptibility to PAHs only at low PAH exposure.

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“…An association between deficient GSTM1 activity and an increased risk of adenocarcinoma of the lung among smokers would be a cofounding factor (Seidegard et al, 1990). And some studies suggested that the GSTM1 null genotype is associated with increased risk of squamous cell carcinoma of lungs which is the lung cancer most clearly related to smoking (Hirvonen et al, 1993;Kihara et al, 1994). On the other hand, other authors found a significant negative correlation between adenocarcinoma of lung and the GSTM1 null genotype and a significant positive correlation to adenocarcinoma of colon (Zhong et al, 1991;.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients

Hong

Chang²,

Kwon³

et al. 1998

Exp Mol Med

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The levels of expressions and catalytic activities of cytochrome P450 (CYP1A1) and glutathione-S-t r a n sferase class (GSTM1) enzymes in lungs and their metabolic balance may be an important determinant host factor underlying lung cancer. Genetic differences in metabolism, MspI restriction sites, Ile-Val polymorphism of CYP1A1 gene, and the null genotype of GSTM1 have been reported to be associated with susceptibility to lung cancer. The present studies were undertaken to establish frequencies of the polymorphic genotypes of CYP1A1 and GSTM1 in Koreans, and to evaluate linkage disequilibrium of the genotypes associated with higher lung cancer risks among Koreans. GSTM1(-) genotype was found in 52% of control subjects, whereas it was found in 55% of lung cancer patients. The allelic variants in CYP1A1 were distributed differently in lung cancer patients and controls. The heterozygous genotype frequency of the MspI site in lung cancer patients (53%) was higher than in controls (49%). The frequency of Ile/Val genotype of CYP1A1 was low in lung cancer patients, which are mostly squamous cell carcinoma.

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Lung cancer risk of GSTM1 null genotype is dependent on the extent of tobacco smoke exposure

Cited by 102 publications

References 0 publications

Allelotype influence at glutathione S-transferase M1 locus on breast cancer susceptibility

Allelotype influence at glutathione S-transferase M1 locus on breast cancer susceptibility

Cytochrome P450 (CYP) and glutathione S-transferases (GST) polymorphisms (CYP1A1, CYP1B1, GSTM1, GSTP1 and GSTT1) and urinary levels of 1-hydroxypyrene in Turkish coke oven workers

Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients

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