Lung cancer risk of the GSTM1 null genotype is enhanced in the presence of the GSTP1 mutated genotype in male Japanese smokers

Kihara, Masako; Kihara, Masahiro; Noda, Kazumasa

doi:10.1016/s0304-3835(98)00337-1

Cited by 61 publications

(26 citation statements)

References 32 publications

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“…This is in contrast to another study in which it was reported that the GSTM1 genotype was associated with an increased risk of dysmenorrhea [23]. However, more recent studies have reported results similar to our findings, although these studies focused on the association of GST-related genes with endometriosis [9,10,31,32]. Nevertheless, the possibility of a false-negative result due to the low statistical power of our analysis cannot be excluded, and further study with a larger sample size will be necessary.…”

Section: Discussioncontrasting

confidence: 57%

Estrogen receptor 1, Glutathione S-transferase P1, Glutathione S-transferase M1, and Glutathione S-transferase T1 Genes with Dysmenorrhea in Korean Female Adolescents

2010

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76Background : Dysmenorrhea is the most common gynecologic complaint among adolescent females. We investigated the association between genetic polymorphisms and dysmenorrhea.Methods : A total of 202 postmenarcheal Korean female adolescents 16-17 yr old participated in this study. Genotyping for glutathione S-transferase mu 1 (GSTM1), glutathione S-transferase theta 1 (GSTT1), glutathione S-transferase pi 1 (GSTP1), and estrogen receptor 1 (ESR1) was performed using PCR-based methods.Results : The PP+Pp genotype of the ESR1 gene was more frequent than pp genotypes in subjects with dysmenorrhea than in subjects without dysmenorrhea (odds ratio=2.440; 95% confidence interval, 1.036-5.753; P=0.040) using an unadjusted univariate logistic regression analysis. The relationship between dysmenorrhea and ESR1 gene polymorphisms remained significant after adjustment for premenstrual syndrome, years elapsed after menarche, and family history of dysmenorrhea. No significant difference was observed between subjects with dysmenorrhea and subjects without dysmenorrhea for polymorphisms of GSTM1, GSTT1, and GSTP1 genes.Conclusions : Our results suggest that ESR1 gene polymorphisms may be associated with dysmenorrhea. (Korean J Lab Med 2010;30:76-83)

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Section: Discussioncontrasting

confidence: 57%

Estrogen receptor 1, Glutathione S-transferase P1, Glutathione S-transferase M1, and Glutathione S-transferase T1 Genes with Dysmenorrhea in Korean Female Adolescents

2010

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“…The most of the studies have been monitoring the association of GSTP1 polymorphism in codon 105 and lung cancer did not prove significant risk of GSTP1 Val genotype (28, 33,[44][45][46][47][48][49][50]. Not even in our study was found significant association between polymorphism of GSTP1 and AC or SCC formation.…”

Section: Discussioncontrasting

confidence: 45%

Lung Adenocarcinoma and Squamous Cell Carcinoma in association with Genetic Polymorphisms of GSTs in Slovak Population

Dzian¹,

Halašová²,

Matáková³

et al. 2012

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Slovak Republic belongs to the countries with high incidence of lung cancer. Gene polymorphisms of the glutathione S-transferases (GSTs) may play a role in individual lung cancer susceptibility. In presented case-control study we investigate the incidence of polymorphism of GSTT1, GSTM1, GSTP1 genes and their combinations as possible predictive factors for identification of individuals with increased risk of formation and development of adenocarcinoma (AC) and squamous cell carcinoma (SCC) of lung in Slovak population. The study was conducted on 520 individuals consisting of 118 patients with adenocarcinoma, 112 patients with squamous cell carcinoma and 290 control individuals. GSTT1, GSTM1, GSTP1 gene polymorphisms were assayed by standard PCR and PCR-RFLP technique. The results of this study indicate that the GSTT1null-genotype and combination GSTT1 null and Ile/Val or Val/Val are associated with increased risk of lung adenocarcinoma. A significant association with 2.13 -fold increased risk was observed between lung adenocarcinoma and GSTT1 null genotype (95% CI = 1.29 -3.51; p= 0.004). Also it was proved 2.83 times statistically higher risk for development of this histological type of lung cancer (95% CI = 1.34 -6.01; P = 0.005) in combination of GSTT1null and Ile/Val or Val/Val genotypes. GSTT1, GSTM1, GSTP1 polymorphism did not show any significant association with SCC. Our study suggests that genetic make-up in metabolizing genes may increase susceptibility towards lung cancer development.

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“…Simultaneous analysis of the GSTM1 and GSTP1 loci was conducted for bladder cancer in only one study from Germany (Steinho et al 2000) in which an increased risk was not observed. On the other hand, in a Japanese lung cancer study (Kihara et al 1999) and a U.S. breast cancer study (Helzlsouer et al 1998) where the high-risk genotypes of the GSTM1 and GSTP1 loci were analysed simultaneously, an increased risk on combination of high-risk genotypes was detected. Interestingly, when we combined the three risk genotypes, the odds ratio ®gure increases to eight.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of glutathione S -transferase genes ( GSTM1 , GSTP1 and GSTT1 ) and bladder cancer susceptibility in the Turkish population

Toruner

Akyerli

Uçar

et al. 2001

Archives of Toxicology

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Lung cancer risk of the GSTM1 null genotype is enhanced in the presence of the GSTP1 mutated genotype in male Japanese smokers

Cited by 61 publications

References 32 publications

Estrogen receptor 1, Glutathione S-transferase P1, Glutathione S-transferase M1, and Glutathione S-transferase T1 Genes with Dysmenorrhea in Korean Female Adolescents

Estrogen receptor 1, Glutathione S-transferase P1, Glutathione S-transferase M1, and Glutathione S-transferase T1 Genes with Dysmenorrhea in Korean Female Adolescents

Lung Adenocarcinoma and Squamous Cell Carcinoma in association with Genetic Polymorphisms of GSTs in Slovak Population

Polymorphisms of glutathione S -transferase genes ( GSTM1 , GSTP1 and GSTT1 ) and bladder cancer susceptibility in the Turkish population

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