Lung Surfactant Proteins A and D as Pattern Recognition Proteins

Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury

“…Collectins such as MBL, SP-A ,and SP-D are multifunctional molecules that can trigger several independently operating effector responses of the innate immune system (6,7,9,10). The present study identifies complement as one such effector mechanism triggered by CL-11 on RTECs.…”

“…Collectin-11 (CL-11, also known as CL-K1 and encoded by COLEC11) is a recently described component of innate defense that is synthesized by several types of nonimmune cells, including epithelial cells of the renal tract and mucosal cells in the intestinal and bronchial tracts (3,4). The collectin family of innate immune molecules to which CL-11 has been assigned (5) are soluble C-type lectins involved in pattern recognition and include mannan-binding lectin (MBL) and the surfactant proteins SP-A and SP-D (6,7).…”

The Porcine Pulmonary Surfactant Protein A (pSP-A) Immunogenicity Evaluation in the Murine Model

“…This protein belongs to a group of soluble humoral pattern recognition receptors, called collectins, which modulate the immune response to microorganisms [1]. The primary unit of a collectin contains an amino-terminal collagen like domain and a carboxyl terminal lectin or carbohydrate recognition domain (CRD) united by a more hydrophobic neck.…”

Toll-like Receptor 2 (TLR2), Transforming Growth Factor-β, Hyaluronan (HA), and Receptor for HA-mediated Motility (RHAMM) Are Required for Surfactant Protein A-stimulated Macrophage Chemotaxis

“…Toll-like receptors (TLRs) 3 and a family of proteins called collectins play central roles in regulation of host defense via recognition of specific pathogen-associated molecular patterns (PAMPs) on various microorganisms (1). Although these innate immune receptors are widely expressed, they are of particular importance to dendritic cells and macrophages.…”