Lutein nanocrystals as antioxidant formulation for oral and dermal delivery

Mitri, Khalil; Shegokar, Ranjita; Gohla, Sven; Anselmi, Cecilia; Müller, Rainer H.

doi:10.1016/j.ijpharm.2011.08.026

Cited by 138 publications

(67 citation statements)

References 21 publications

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“…Penetration of nanocrystals from a synthetic cellulose nitrate membrane showed 35 % lutein release at 6 h and 60 % at 24 h, while it was <5 % for coarse suspension [30]. In vivo skin tape stripping experiments in human volunteers exhibited 18 times higher penetration for lutein nanosuspension in the stratum corneum.…”

Section: Penetration Enhancementmentioning

confidence: 92%

Wet Media Milling: An Effective Way to Solve Drug Solubility Issue

Shegokar¹

2015

Handbook of Nanoparticles

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Drug synthesis, high-throughput screening generates billions of poorly soluble drugs which are neglected in further developments due to solubility issues. In the last 20 years, nanonization by milling is being effectively used commercially to save these drugs by overcoming solubility problems in commercial way. Various labs at industry and academic level successfully investigated milling technique alone and in combination with other techniques to reduce particle size, thereby increasing the dissolution velocity of drug. Milling offers ease of production, efficient control of production parameters, freedom of small to industrial batch size, liberty to produce highly concentrated suspensions, and improved stability of final product. Nanonized slurries exhibited promising results in vitro and in vivo and many fold increase in bioavailability. Nanosuspensions are investigated for organ or cellular delivery in various diseases like HIV/AIDS, malaria, and other infectious disease conditions. The issue of metal abrasion and contamination is now nullified by effective engineering solutions. In this chapter, recent updates on milling techniques and their applications in pharmaceutical field are discussed.

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Section: Penetration Enhancementmentioning

confidence: 92%

Wet Media Milling: An Effective Way to Solve Drug Solubility Issue

Shegokar¹

2015

Handbook of Nanoparticles

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“…ZP values represent an indication of potential physical stability of colloidal systems (27). As shown in Table I, the ZP values of emulsions with MDX were lower than the one without MDX after homogenization.…”

Section: Characterization Of Emulsionsmentioning

confidence: 95%

The Influence of Maltodextrin on the Physicochemical Properties and Stabilization of Beta-carotene Emulsions

Zhang

Wang

et al. 2016

AAPS PharmSciTech

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Beta-carotene is important for fortification of nutritional products while its application is limited by instability. The influence of maltodextrin (MDX) on physicochemical properties and stability of beta-carotene emulsions stabilized by sodium caseinate (SC) was investigated. The emulsions were characterized by dynamic light scattering (DLS), laser diffraction (LD), transmission electron microscopy (TEM), rheometer, and turbiscan lab expert. The effects of pH, ionic strength, and freeze-thaw on stability of emulsions were observed. The emulsions could tolerate up to 2 mol/L NaCl or 10 mmol/L CaCl and showed Newtonian behavior. The droplet diameter, polydispersity index, and zeta-potential did not change obviously after 3 months storage at 4°C in dark conditions. The emulsions with MDX showed excellent freeze-thaw stability and gave favorite protection for beta-carotene. The retention ratio of beta-carotene in the emulsions with MDX was above 92.1% after 3 months storage while that in the one without MDX was only 62.7%. The study may provide a promising strategy to improve stability of sensitive nutraceuticals without adding synthetic antioxidants. The findings obtained could provide fundamental basis for rational design of emulsion delivery systems when freeze-thawing is required during manufacturing process or storage period.

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“…Nanoparticles formed by anti-solvent precipitation show low polydispersity and high encapsulation With respect to food industry, nanoprecipitates produced by solvent displacement mainly aim to incorporate active substances that degrade under common processing conditions (heat, pH, light and mechanical stress), enhancing bioactive payload compared to conventional encapsulation, and to achieve customized release under GI digestion conditions. Solvent displacement nanoprecipitation is regarded as a very efficient method to entrap and stabilize lipophilic substances including carotenoids or hydrophobic polyphenols (curcumin), in food matrices, as well as to improve bioavailability (Chu et al, 2007a;Faisal et al, 2013;Kakran et al, 2012;Lobato et al, 2013;Mitri et al, 2011;Panagiotou and Fisher, 2013;Patel et al, 2010;Ribeiro et al, 2008;Tachaprutinun et al, 2009;Yin et al, 2009). …”

Section: Solvent Displacementmentioning

confidence: 99%

A comprehensive overview on the micro- and nano-technological encapsulation advances for enhancing the chemical stability and bioavailability of carotenoids

Soukoulis

Bohn

2017

Critical Reviews in Food Science and Nutrition

209

135

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Carotenoids are lipophilic secondary plant compounds, and their consumption within fruits and vegetables has been positively correlated with a decreased risk of developing several chronic diseases. However, their bioavailability is often compromised due to incomplete release from the food matrix, poor solubility and potential degradation during digestion. In addition, carotenoids in food products are prone to oxidative degradation, not only lowering the nutritional value of the product but also triggering other quality deteriorative changes, such as formation of lipid pro-oxidants (free radicals), development of discolorations or off-flavor defects. Encapsulation refers to a physicochemical process, aiming to entrap an active substance in structurally engineered micro- or nano-systems, in order to develop an effective thermodynamical and physical barrier against deteriorative environmental conditions, such as water vapor, oxygen, light, enzymes or pH. In this context, encapsulation of carotenoids has shown to be a very effective strategy to improve their chemical stability under common processing conditions including storage. In addition, encapsulation may also enhance bioavailability (via influencing bioaccessibility and absorption) of lipophilic bioactives, via modulating their release kinetics from the carrier system, solubility and interfacial properties. In the present paper, it is aimed to present the state of the art of carotenoid microencapsulation in order to enhance storability and bioavailability alike.

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Lutein nanocrystals as antioxidant formulation for oral and dermal delivery

Cited by 138 publications

References 21 publications

Wet Media Milling: An Effective Way to Solve Drug Solubility Issue

Wet Media Milling: An Effective Way to Solve Drug Solubility Issue

The Influence of Maltodextrin on the Physicochemical Properties and Stabilization of Beta-carotene Emulsions

A comprehensive overview on the micro- and nano-technological encapsulation advances for enhancing the chemical stability and bioavailability of carotenoids

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