Luteolin as a modulator of skin aging and inflammation

Abstract

Luteolin belongs to the group of flavonoids and can be found in flowers, herbs, vegetables and spices. It plays an important role in defending plants, for example against UV radiation by partially absorbing UVA and UVB radiation. Thus, luteolin can also decrease adverse photobiological effects in the skin by acting as a first line of defense. Furthermore, anti-oxidative and anti-inflammatory activities of luteolin were described on keratinocytes and fibroblasts as well as on several immune cells (e.g., macrophages, mast cell, neutrophils, dendritic cells and T cells). Luteolin can suppress proinflammatory mediators (e.g., IL-1β, IL-6, IL-8, IL-17, IL-22, TNF-α and COX-2) and regulate various signaling pathway (e.g., the NF-κB, JAK-STAT as well as TLR signaling pathway). In this way, luteolin modulates many inflammatory processes of the skin. The present review summarizes the recent in vitro and in vivo research on luteolin in the field of skin aging and skin cancer, wound healing as well as inflammatory skin diseases, including psoriasis, contact dermatitis and atopic dermatitis.In conclusion, luteolin might be a promising molecule for the development of topic formulations and systemic agents against inflammatory skin diseases.

Developmental Stage Determines the Accumulation Pattern of UV-Absorbing Compounds in the Model Liverwort Marchantia polymorpha subsp. ruderalis under Controlled Conditions

“…Flavones are one of the biggest families of flavonoids and their functions in plants include protection against UV radiation and oxidative stress, signaling, and interactions with other organisms [30,31]. In addition, both apigenins and luteolins are interesting medicinal compounds [30,32]. The flavones found in our study coincided with some of those previously found in M. polymorpha subsp.…”

Comparative Analysis of Flavonoid Metabolites in Foxtail Millet (Setaria italica) with Different Eating Quality

“…Recent research pointed out that luteolin might be a promising molecule for developing topic formulations and systemic agents against inflammatory skin diseases. It has also been suggested as a cancer chemopreventive agent [ 49 , 50 ]. In our study, luteolin was abundant in three high-quality foxtail millet varieties but absent in the other two varieties.…”

Luteolin Orchestrates Porcine Oocyte Meiotic Progression by Maintaining Organelle Dynamics Under Oxidative Stress

“…Lut can stabilize the radical group by donating hydrogen/electron of C2–C3 double bond to radical and by blocking Fenton reaction using oxo group at C4 that binds transitional metal ions including iron and copper. These two structural features of Lut inhibit pro-oxidant enzymes such as xanthine oxidase, and induce antioxidant enzymes ( Gendrisch et al, 2021 ). In addition, Lut not only has its own antioxidant activity, but also interacts with other antioxidants such as vitamins and cellular redox system ( Gendrisch et al, 2021 ), indicating that Lut can synergistically enhance its antioxidant properties.…”

“…These two structural features of Lut inhibit pro-oxidant enzymes such as xanthine oxidase, and induce antioxidant enzymes ( Gendrisch et al, 2021 ). In addition, Lut not only has its own antioxidant activity, but also interacts with other antioxidants such as vitamins and cellular redox system ( Gendrisch et al, 2021 ), indicating that Lut can synergistically enhance its antioxidant properties. Furthermore, some flavonoids including quercetin, genistein, and catechin induce DNA damage by pro-oxidative effect resulting in mutagenic and carcinogenic activity ( Kawanishi et al, 2005 ; Gendrisch et al, 2021 ), but Lut has no report regarding these effects, suggesting that Lut can be expected as a comparatively safe antioxidant ( Yamashita et al, 1999 ).…”