Luteolin attenuates imiquimod–induced psoriasis-like skin lesions in BALB/c mice via suppression of inflammation response

Zhou, Wei; Hu, Mengmeng; Zang, Xiaohao; Liu, Qifa; Du, Jiantang; Hu, Jingrong; Zhang, Lanyue; Du, Zhiyun; Xiang, Zhangmin

doi:10.1016/j.biopha.2020.110696

Cited by 45 publications

(28 citation statements)

References 42 publications

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“…Similar in vivo results were found in murine studies with luteolin‐7‐O‐β‐D‐glucuronide 75 . A very recent study confirmed these results with luteolin and could also show an effect of luteolin leading to suppression of nitric oxide, iNOS and COX‐2 76 . In addition, LUT‐7G inhibited the cellular energy production of keratinocytes by an interaction with hexokinase 2 that leads to a depression of the glycolytic and Krebs pathway 74 .…”

Section: Inflammatory Skin Diseasessupporting

confidence: 77%

“…75 A very recent study confirmed these results with luteolin and could also show an effect of luteolin leading to suppression of nitric oxide, iNOS and COX-2. 76 In addition, LUT-7G inhibited the cellular energy production of keratinocytes by an interaction with hexokinase 2 that leads to a depression of the glycolytic and Krebs pathway. 74 However, studies on the effect of luteolin in psoriasis patients are still scarce.…”

Section: Psoriasismentioning

confidence: 99%

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Luteolin as a modulator of skin aging and inflammation

et al. 2020

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Luteolin belongs to the group of flavonoids and can be found in flowers, herbs, vegetables and spices. It plays an important role in defending plants, for example against UV radiation by partially absorbing UVA and UVB radiation. Thus, luteolin can also decrease adverse photobiological effects in the skin by acting as a first line of defense. Furthermore, anti-oxidative and anti-inflammatory activities of luteolin were described on keratinocytes and fibroblasts as well as on several immune cells (e.g., macrophages, mast cell, neutrophils, dendritic cells and T cells). Luteolin can suppress proinflammatory mediators (e.g., IL-1β, IL-6, IL-8, IL-17, IL-22, TNF-α and COX-2) and regulate various signaling pathway (e.g., the NF-κB, JAK-STAT as well as TLR signaling pathway). In this way, luteolin modulates many inflammatory processes of the skin. The present review summarizes the recent in vitro and in vivo research on luteolin in the field of skin aging and skin cancer, wound healing as well as inflammatory skin diseases, including psoriasis, contact dermatitis and atopic dermatitis.In conclusion, luteolin might be a promising molecule for the development of topic formulations and systemic agents against inflammatory skin diseases.

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Section: Inflammatory Skin Diseasessupporting

confidence: 77%

Section: Psoriasismentioning

confidence: 99%

Luteolin as a modulator of skin aging and inflammation

et al. 2020

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“…a glabridin-dose-dependent reduction of epidermal thickness and lymphocyte infiltration in the dermis [71]; therefore, glabridin is an effective anti-psoriasis bioactive compound. Meanwhile, luteolin, plant derived flavonoids, in a dosedependent manner suppressed the iNOS protein produced by RAW264.7 cells after LPS stimulation, which was beneficial to alleviation of imiquimod-induced psoriasis-like skin lesions in BALB/c mice [72]. A preclinical evidence supports that EGCG from flavanols can significantly attenuate clinical symptoms (like pruritus) and pathologic features (like epidermal hyperplasia and dermal inflammatory cells infiltration) on imiquimod-induced psoriasis-like mice via restraining OS and inflammation-related pathways especially Akt signaling pathway [73].…”

Section: Flavonoids In Psoriasismentioning

confidence: 96%

Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses

Xian

Guo

et al. 2021

Redox Report

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Background: Skin, as a crucial external defense organ, is more vulnerable to oxidative stress (OS) insult, reactive oxygen species (ROS)-mediated OS in particular. OS results from a redox imbalance caused by various extrinsic stimuli and occurs once the oxidants production overwhelming the antioxidants capacity, through mediating in DNA damage, lipid peroxidation (LPO), protein oxidation and a serial of signaling pathways activation/inactivation, thereby offering favorable conditions for the occurrence and development of numerous diseases especially some dermatoses, e.g. psoriasis, vitiligo, skin photodamage, skin cancer, systemic sclerosis (SSc), chloasma, atopic dermatitis (AD), pemphigus, etc. Targeting OS molecular mechanism, a variety of anti-OS agents emerge, in which flavonoids, natural plant extracts, stand out. Objectives: To discuss the possible mechanisms of OS mediating in dermatoses and summarize the properties of flavonoids as well as their applications in OS-related skin disorders. Methods: Published papers on flavonoids and OS-related skin diseases were collected and reviewed via database searching on PubMed, MEDLINE and Embase, etc. Results: It has been confirmed that flavonoids, belonging to polyphenols, are a class of plant secondary metabolites widely distributed in various plants and possess diverse bioactivities especially their potent antioxidant capacity. Moreover, flavonoids benefit to suppress OS via eliminating free radicals and mediating the corresponding signals, further excellently working in the prevention and management of OS-related skin diseases. Conclusion: Flavonoids have the potential therapeutic effects on oxidative stress-related dermatoses. However, more studies on specific mechanism as well as the dosage of flavonoids are needed in future.

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“…Luteolin (Lut), a flavonoid obtained from various plants, has been shown to confer anti-inflammatory, anti-oxidative, and neuroprotective effects ( Zhou W. et al, 2020 ). The methods for Lut extraction involve maceration, Soxhlet, reflux, ultrasound-assisted, enzyme-assisted, and supercritical fluid extraction ( Manzoor et al, 2019 ).…”

Section: Nature Productsmentioning

confidence: 99%

Role of Plant-Derived Natural Compounds in Experimental Autoimmune Encephalomyelitis: A Review of the Treatment Potential and Development Strategy

et al. 2021

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Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is mainly mediated by pathological T-cells. Experimental autoimmune encephalomyelitis (EAE) is a well-known animal model of MS that is used to study the underlying mechanism and offers a theoretical basis for developing a novel therapy for MS. Good therapeutic effects have been observed after the administration of natural compounds and their derivatives as treatments for EAE. However, there has been a severe lag in the research and development of drug mechanisms related to MS. This review examines natural products that have the potential to effectively treat MS. The relevant data were consulted in order to elucidate the regulated mechanisms acting upon EAE by the flavonoids, glycosides, and triterpenoids derived from natural products. In addition, novel technologies such as network pharmacology, molecular docking, and high-throughput screening have been gradually applied in natural product development. The information provided herein can help improve targeting and timeliness for determining the specific mechanisms involved in natural medicine treatment and lay a foundation for further study.

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Luteolin attenuates imiquimod–induced psoriasis-like skin lesions in BALB/c mice via suppression of inflammation response

Cited by 45 publications

References 42 publications

Luteolin as a modulator of skin aging and inflammation

Luteolin as a modulator of skin aging and inflammation

Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses

Role of Plant-Derived Natural Compounds in Experimental Autoimmune Encephalomyelitis: A Review of the Treatment Potential and Development Strategy

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