LXXIII Juvenile Nasopharyngeal Fibroma in State of Regression

The Nature of Juvenile Nasopharyngeal Angiofibroma

“…Consequently, we believe that JNA is the same as most hemangiomas by nature-a vascular hamartoma or a pathologic and reactive proliferation of vessels. In fact, some authors have claimed that JNA is not a true tumor and have considered it to be an inflammatory or immune response, 11 the result of sex hormone imbalance, 2,12 or a vascular hamartoma. 4 Beranek 5 proposed an angiogenic histogenetic hypothesis of JNA, which suggested that all components in JNA are derived from vascular endothelium.…”

Involution of residual juvenile nasopharyngeal angiofibroma

“…Its origin has been open to considerable doubt; thus Ringertz (1938) and Som and Neffson (1940) supposed it had origin from the periosteum of the base of the skull; Hughes (1941) suggested that it may arise from the remnants of the craniopharyngeal duct; Willis (1953) suggested that it was the result of an immune inflammatory response, and Martin (1954) and Dane (1954) suggested that it was the result of hormonal disturbances. Modern consensus opinion, however, suggests that it has a primarily vascular origin, although there is disagreement on the precise form of this (Maurice and Milad, 1981).…”

Die vaskuläre Komponente: Gedanken zur Entstehung des Angiofibroms

“…Martin u. Mitarb. [15] sowie Dane [16] rückten die Bedeutung hormoneller Einflüsse (Androgenüberschuss bzw. Androgenmangel bei Östrogenüberschuss) in den Mittelpunkt.…”