LXXXI. Zur Kenntniss der Bromnitrobenzolsäuren

“…The starting bromonitroaniline 34 has been prepared by a number of methods, but the most popular are 1) nitration of p -bromoaniline or its derivatives [ 50 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 ], and 2) bromination of o -nitroaniline or its derivatives, usually with bromine in acetic acid [ 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 ]. Here, too, each of these methods has its shortcomings.…”

Section: Preparation Tyrian Purple From 4-bromo-2-nitrobenzaldehydmentioning

confidence: 99%

“…The major drawback of the Friedländer method is the expense of the starting bromoanthranilic acid 43 . This compound had previously been prepared by Claus and Scheulen [ 88 ] from 4-bromo-2-nitroaniline ( 34 , from nitration of 39 ) by diazotization and conversion to the nitrile 50 , hydrolysis to the acid 51 and reduction with zinc chloride ( Scheme 15 ).…”

Section: Preparation Of Tyrian Purple From 4-bromo-2-aminobenzoic mentioning

confidence: 99%

Preparation of Tyrian Purple (6,6′-Dibromoindigo): Past and Present

Wolk

Frimer

2010

Molecules

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“…hexane, C = chlorobenzene, E = ethanol, W = water, HP = heptane. 6 All melting points, taken on a Fisher-Johns melting point apparatus, are corrected. 6 S.a. = Staphylococcus aureus; + represents growth at a concentration of 1 X 10s; T, 10T, 100T, and M represent no growth at a concentration of 1 X 10s, 1 X 10s, 1 X 105, and 1 X 10s, respectively.…”

mentioning

confidence: 99%

“…d F. Beilstein and A. Kurbatow [Ann., 182, 94 (1876)] give mp 141-142°. 6 Methyl group substituted on N. 1 Refractive index, n25d. 0 Anal.…”

mentioning

confidence: 99%

Halonitroanilides and Their Bacteriostatic Activity

Baker¹,

Schumacher²,

Bachman³

et al. 1966

J. Med. Chem.

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Vol. 0 and 6 are the same(') pg/nil), although the chemical and physical properties of the n-butyl, isobutyl, see-butyl, and /-butyl compounds vary significantly. Likewise, unsaturation in the alkyl chain does not seem to influence the bacteriostatic activity. The MIC of the 9-n-decenyl compound ( 14) is 1 he same as that of the n-decyl derivative (13). However, slight changes in the anilide portion of the molecule cause considerable variation in activity. For example, l-(3,4-diehlorophenyl)-3-Ai"Oetyhm>a (10) inhibited the test organism at 0.2 pg/ml, whereas l-(4-chlorophenyl)-8-a-octylurea (27) did not inhibit the organism at 20 gg 'ml. Since the bisureas (20-26) were not effective at the highest concentration tested ("i gg/ml), no relationship of chain length to activity can be postulated. It is interesting to note that 3,4-dichloroaniline, an expected hydrolysis product from all these compounds, is not as active under our test conditions as most of the ureas.These compounds were also tested against Escherichia cali ATOO 11229. They were found to be inactive1 at."A) Mg/'ml.Acknowledgments. The1 authors wish to express their sincere appreciation to l)rs. E. Jungermann and D. Taber and to Mrs. Belen C. Brown for many helpful discussions, and to James McMenamiti and Mrs. Maria Trutenko for many of the necessary chemical and bacteriological analyses.

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LXXXI. Zur Kenntniss der Bromnitrobenzolsäuren

Cited by 4 publications

References 3 publications

Substitution, Oxidation and Group Participation in the Bromination of Indoles

Substitution, Oxidation and Group Participation in the Bromination of Indoles

Preparation of Tyrian Purple (6,6′-Dibromoindigo): Past and Present

Halonitroanilides and Their Bacteriostatic Activity

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