Lycopene Ameliorate the Gentamicin Induced Nephrotoxicity in White Mice Model

Abstract

Gentamicin is an aminoglycoside antibiotic used against gram-negative bacterial infections. In the face of antibiotics, gentamicin also has a toxic effect on kidney. This study investigated the protective role of lycopene against gentamicin induced nephrotoxicity. Results of this works found that lycopene has a great protective effect on the oxidative status of the kidney challenged with gentamicin and significantly ameliorated (P £ 0.05) the level of oxidative markers MDA, GPx and SOD in kidney cells. Kidney function markers (serum urea and creatinine) were ameliorated by using lycopene in comparison with mice challenged by gentamicin. Results of this work showed that lycopene decreased the pro-inflammatory cytokines (IL-6 and TNF-á) and anti-inflammatory cytokines (IL-4 and IL-10). mRNA expression rate of different investigated cytokine markers were modified significantly (P £ 0.05) in lycopene treated group. Serum glucose also adjusted significantly using lycopene. Oxidative stress results were confirmed by histopathological investigations those showed a protective effect of lycopene of kidney tubules.

The Protective Effect of Garden Cress Lepidium sativum against Lipopolysaccharide (LPS) Induced Hepatotoxicity in Mice Model

“…LPS is a very powerful immunological stimulator and is called bacterial endotoxins. Where it can be recognized by innate immune receptors and then signals and activate many cascades those finally leads to release many proinflammatory cytokines (Sayed, 2019). Purified LPS is…”

“…The Protective Effect of Garden Cress Lepidium sativum against Lipopolysaccharide (LPS) Induced Hepatotoxicity in Mice Model used as a potent antigen by so many searcher groups (Brydon et al, 2009) where it has a powerful antigenic characters that may finally leads to failure of many body organs. LPS-induced liver injuries were reported by many studies (Sayed, 2019). One exposure to LPS considered as hepatotoxic xenobiotic and leads finally to direct liver necrosis (Abdel-Razaq et al, 2007;Sayed 2019).…”

“…LPS-induced liver injuries were reported by many studies (Sayed, 2019). One exposure to LPS considered as hepatotoxic xenobiotic and leads finally to direct liver necrosis (Abdel-Razaq et al, 2007;Sayed 2019). Many groups were recorded that plant seeds have an antioxidant and hepatoprotective effects (Najeeb et al, 2011).…”