Lycopene: An antioxidant and radioprotector against γ-radiation-induced cellular damages in cultured human lymphocytes

Srinivasan, M.; Nagarajan, Devipriya; Kalpana, K; Menon, Venugopal P.

doi:10.1016/j.tox.2009.05.004

Cited by 73 publications

(50 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Srinivasan et al µg/mL) significantly decreased the frequency of cellular changes and increased the previously reduced glutathione levels compared with the gamma-radiated control group with no lycopene pre-treatment (23). The dose of 5 µg/mL of lycopene was found to be more effective than the other two doses (23). Consistent with the mentioned studies, we also demonstrated that pre-treatment with lycopene could offer protection of normal lymphocytes against gammaradiation-induced cellular damage.…”

Section: Discussionsupporting

confidence: 88%

“…Other studies also reported similar in vitro protection effects of lycopene. In Srinivasan et al µg/mL) significantly decreased the frequency of cellular changes and increased the previously reduced glutathione levels compared with the gamma-radiated control group with no lycopene pre-treatment (23). The dose of 5 µg/mL of lycopene was found to be more effective than the other two doses (23).…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

In vivo Time-Dependent Radio-Protective Effect of Lycopene Against Whole-Body Gamma Radiation in Mice

Oladi

Sazgarnia

Nasiri

et al. 2016

Iran Red Crescent Med J

View full text Add to dashboard Cite

Background: Ionizing radiation has become an essential part of modern medicine. However, applying the effective dose of ionizing radiation is compromised by its inevitable radiation-induced damage to normal tissues. Natural products with free radical scavenging, antioxidant activities, and immune stimulatory effects offer suitable radio-protective effects. Objectives: This study was designed to evaluate the in vivo radio-protective activity of lycopene, a naturally dietary carotenoid, against whole-body gamma-irradiation-induced mortality and sickness in mice. Methods: In this animal experimental study, lycopene was extracted from tomato paste, characterized, and then administered to mice. Consecutively, 80 healthy adult male mice were recruited and irradiated individually, and then monitored for irradiation sickness and survival parameters. Results: Pretreatment with 7 mg/kg dose of lycopene 7 days before irradiation was found to reduce the severity of symptoms of radiation sickness in a 30-day post-radiation monitoring. Lycopene treatment increased the survival rate. At the radiation dosage of 8 and 9 Gy, the difference between the survival rates of control and sample groups became significant after day 15 and 25. Lycopene was also shown to have a protective effect on white blood cell count against 8 and 9 Gy gamma radiations. Conclusions: Natural and exhibiting whole-body radio-protective activity, lycopene can be proposed as an effective radio-protector in healthy people who are exposed to radiation, such as radiographers, nuclear pharmacists, and radiologists.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 93%

In vivo Time-Dependent Radio-Protective Effect of Lycopene Against Whole-Body Gamma Radiation in Mice

Oladi

Sazgarnia

Nasiri

et al. 2016

Iran Red Crescent Med J

View full text Add to dashboard Cite

show abstract

“…These were in accordance with studies which come to the fact that the imbalance in antioxidant status in the cells as a result of ionizing may be ameliorated as result of administration of Lycopene [20]. Lycopene significantly restored the antioxidant enzymes Superoxide Dismutase (SOD), Glutathione Peroxidase (GSHPx), and Glutathione Reductase (GR); Reduced Glutathione (GSH); and decreased levels of the lipid peroxide Malondialdehyde (MDA) in hypertensive patients [21]. Lycopene was found to have a favorable effect in reducing MDA levels and increasing GSH levels in coronary artery disease in postmenopausal women [22].…”

Section: Discussionsupporting

confidence: 88%

“…Other interesting finding in this study was that lipid droplets still found in Lycopene treated animals in considerable averages compared to γ-irradiated rats [28]. This is may be due to the antioxidant sparing action of Lycopene in decreasing lipid peroxidation and improved antioxidant status preventing the damage to the cell [21].…”

Section: Discussionmentioning

confidence: 49%

“…The nucleus, mitochondria get its normality [25,26]. These results run barrel with Srinivasan [21], who showed that pretreatment with Lycopene offers protection to normal lymphocytes against γ-radiation-induced cellular damage due to free radical released by radiation reaction inside the cell. The ameliorative effect of Lycopene may be resulted from; it acts as a scavenger to the free radicals that causes damage to the cells and tissues.…”

Section: Discussionmentioning

confidence: 85%

See 1 more Smart Citation

Structural Studies on the Radio-Protective Effect of Lycopene (Tomato Supplementation) Against Hepatic Cellular Injury Induced by Chronic Doses of Gamma Radiation

Waer¹,

Shalaby²

2012

J Cytol Histol

View full text Add to dashboard Cite

Background and aim: Antioxidants are substances that may protect our bodies against the effects of freeradicals. Free radicals are molecules produced when our body breaks down food, or by environmental exposures like radiation. Free radicals can damage cells, our goal of this work is to study the damage resulted by chronic low doses of gamma radiation using natural antioxidant like Lycopene that found in tomato that are available to most of the people especially those that work in the field of radiation.

show abstract

Protective rules of natural antioxidants against gamma‐induced damage—A review

Jameel

Mohammed

2021

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

Lycopene: An antioxidant and radioprotector against γ-radiation-induced cellular damages in cultured human lymphocytes

Cited by 73 publications

References 32 publications

In vivo Time-Dependent Radio-Protective Effect of Lycopene Against Whole-Body Gamma Radiation in Mice

In vivo Time-Dependent Radio-Protective Effect of Lycopene Against Whole-Body Gamma Radiation in Mice

Structural Studies on the Radio-Protective Effect of Lycopene (Tomato Supplementation) Against Hepatic Cellular Injury Induced by Chronic Doses of Gamma Radiation

Protective rules of natural antioxidants against gamma‐induced damage—A review

Contact Info

Product

Resources

About