Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway

Cao, Li; Zhao, Jie; Ma, Li; Chen, Jiawen; Xu, Jingru; Rahman, Sajid Ur; Shi, Feng; Liu, Yu; Wu, Jiawei; Wang, Xichun

doi:10.1016/j.ecoenv.2021.112737

Cited by 30 publications

(17 citation statements)

References 40 publications

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“…205 Lycopene, a fat-soluble carotenoid with high antioxidant potential, is widely present in red tomatoes, makes fruits and vegetables such as watermelon and guava red, and is a food coloring agent. 206 It can prevent ZEN-induced acute toxic effects in male mice. 207 For example, research has shown that lycopene can prevent a decrease in the antioxidant enzyme activity induced by ZEN, inhibit the inflammatory process, and prevent ZEN-induced damage to the mouse testes.…”

Section: Reviewmentioning

confidence: 99%

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Toxicity of zearalenone and its nutritional intervention by natural products

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Section: Reviewmentioning

confidence: 99%

“…208 Additionally, lycopene pretreatment can improve the survival rate of piglet Sertoli cells induced by ZEN, activate the Nrf2/ HO-1 signaling pathway, promote the levels of Nrf2 in the nucleus, upregulate HO-1 and GPX1 relative mRNA levels, increase antioxidant enzyme activity, and decrease MDA and ROS levels. 206…”

Section: Reviewmentioning

confidence: 99%

Toxicity of zearalenone and its nutritional intervention by natural products

et al. 2022

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“…For the rise in the COVID-19-related risk of death, Nrf2 has powerful antiapoptotic effects and anti-inflammatory in endothelial cells. Lycopene reduced the oxidative damage caused by zearalenone (ZEA) in Sertoli cells (SCs) by increasing Nrf2 pathway expression and lowering autophagy and apoptosis in piglet SCs (Cao et al 2021). In HFD-fed mice, lycopene (10 mg/kg) treatment had better anti-lipidemic and anti-antioxidant benefits than Moringa (400 mg/kg), most likely due to its ability to reduce oxidative stress (Greish et al 2021).…”

Section: Oxidative Stress Of Covid-19mentioning

confidence: 99%

Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19)

et al. 2022

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Lycopene is a group of phytochemicals found in nature, primarily in fruits and vegetables. Lycopene is thought to protect against a variety of diseases attributed to its antioxidant capabilities. Lycopene has anti-inflammatory, anti-cancer, and immunity-boosting qualities, among other biological and pharmacological benefits. COVID-19 (coronavirus disease 19) is an infectious disease caused by the SARS-CoV-2 virus, which has recently emerged as one of the world's leading causes of death. Patients may be asymptomatic or show signs of respiratory, cytokine release syndrome, gastrointestinal, or even multiple organ failure, all of which can lead to death. In COVID-19, inflammation, and cytokine storm are the key pathogenic mechanisms, according to SARS-CoV-2 infection symptoms. ARDS develops in some vulnerable hosts, which is accompanied by an inflammatory "cytokine syndrome" that causes lung damage. Immunological and inflammatory markers were linked to disease severity in mild and severe COVID-19 cases, implying that inflammatory markers, including IL-6, CRP, ESR, and PCT were significantly linked with COVID-19 severity. Patients with severe illness have reduced levels of several immune subsets, including CD4 + T, NK, and CD8 + cells. As a result, lycopene can be commended for bolstering physiological defenses against COVID-19 infections

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“…ZEN induces apoptosis and oxidative stress in porcine intestinal epithelial cells, and these cellular damages induced by ZEN are closely linked to several key signaling pathways; it has been shown that glutamine and DL-selenomethionine play a mitigating role in ZEN-induced apoptosis and oxidative stress through PI3K/Akt and Nrf2/Keap1 signaling pathways, respectively [7,8]. According to previous studies, ZEN mainly causes structural damage in the porcine jejunum, inducing inflammation and apoptosis of jejunal epithelial cells [9][10][11]. However, the underlying mechanism of ZEN-induced jejunal epithelial injury is largely unknown.…”

Section: Introductionmentioning

confidence: 97%

Analysis of the Roles of the ISLR2 Gene in Regulating the Toxicity of Zearalenone Exposure in Porcine Intestinal Epithelial Cells

Xiao

et al. 2022

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Zearalenone (ZEN) is one of the mycotoxins that pose high risks for human and animal health, as well as food safety. However, the regulators involved in ZEN cellular toxicity remain largely unknown. Herein, we showed that cell viability of porcine intestinal epithelial cells (IPEC-J2) tended to decrease with increasing doses of ZEN by the cell counting kit-8 assay. Expression of the ISLR2 (immunoglobulin superfamily containing leucine-rich repeat 2) gene in IPEC-J2 cells was significantly downregulated upon ZEN exposure. Furthermore, we found the dose–effect of ZEN on ISLR2 expression. We then overexpressed the ISLR2 gene and observed that overexpression of ISLR2 obviously reduced the effects of ZEN on cell viability, apoptosis rate and oxidative stress level. In addition, ISLR2 overexpression significantly decreased the expression of TNF-α and IFN-α induced by ZEN. Our findings revealed the effects of ZEN on the ISLR2 gene expression and indicated the ISLR2 gene as a novel regulator of ZEN-induced cytotoxicity, which provides potential molecular targets against ZEN toxicity.

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Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway

Cited by 30 publications

References 40 publications

Toxicity of zearalenone and its nutritional intervention by natural products

Toxicity of zearalenone and its nutritional intervention by natural products

Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19)

Analysis of the Roles of the ISLR2 Gene in Regulating the Toxicity of Zearalenone Exposure in Porcine Intestinal Epithelial Cells

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