Lycopene has reduced renal damage histopathologically and biochemically in experimental renal ischemia-reperfusion injury

Kaya, Cevdet; Karabulut, Ramazan; Türkyılmaz, Zafer; Sönmez, Kaan; Kulduk, Gamze; Gülbahar, Özlem; Köse, Faruk; Başaklar, A. Can

doi:10.3109/0886022x.2015.1064742

Cited by 25 publications

(30 citation statements)

References 37 publications

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“…A significant decrease of collagen fibers, desmin, PCNA and caspase-3 reaction were detected. These results were in agreement with previous investigators who reported that lycopene has a protective effect [20,40,41] .…”

Section: Podocytesupporting

confidence: 94%

Histological and Immunohistochemical Study of Titanium Dioxide Nanoparticle Effect on the Rat Renal Cortex and the Possible Protective Role of Lycopene

Salem

Altayeb

El-Mahalaway

2017

Egyptian Journal of Histology

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Introduction: Titanium dioxide nanoparticles (TNPs) have a wide range of applications in industry, medicine and environmental technology. Nowadays, TNPs have raised researcher's concerns on their toxicity. Lycopene is a dietary carotenoid having a potent antioxidant effect. Aim: To evaluate the effect of TNPs on the structure of renal cortex of rats and to assess the possible protective effect of lycopene against TNPs nephrotoxicity. Material and methods: Forty five adult male rats were divided into four groups. Group I (the control group) included 20 rats, which were divided equally into 4 subgroups. Subgroup IA was the negative control, Subgroup IB given one ml corn oil by gastric tube, Subgroup IC given one ml distilled water intraperitoneally (i.p) and Subgroup ID given one ml corn oil by gastric tube and one ml distilled water (i.p). Group II included 5 rats received a daily dose of 10 mg/kg body weight (BW) of lycopene by gastric tube for 4 weeks. Group III included 10 rats injected with 150 mg/kg BW (i.p.) of TNPs daily for 4 weeks. Group IV included 10 rats received both TNPs and lycopene at the same aforementioned doses for 4 weeks. Kidney specimens were prepared and sections were stained with hematoxylin and eosin and Masson's trichrome. Immunohistochemical detection of desmin, anti-proliferating cell nuclear antigen (PCNA) and caspase-3 was done. Results: Our results revealed that group II had similar findings nearly as group I. Group III showed congested dilated glomerular capillaries. The convoluted tubules showed exfoliation of some lining epithelial cells and degenerative changes. There were interstitial haemorrhage, mononuclear cell infiltration and increase in collagen fibers around degenerated convoluted tubules and glomeruli. A significant increase in desmin-expression in the glomerular cells was observed. Besides, there were significant increases of PCNA positive nuclear and caspase-3 cytoplasmic reactions in renal tubular cells. Group IV revealed amelioration of these changes. Conclusion: Lycopene protected rat's renal cortex against TNPs nephrotoxicity.

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Section: Podocytesupporting

confidence: 94%

Histological and Immunohistochemical Study of Titanium Dioxide Nanoparticle Effect on the Rat Renal Cortex and the Possible Protective Role of Lycopene

Salem

Altayeb

El-Mahalaway

2017

Egyptian Journal of Histology

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“…Pektaş et al [17] evaluated the effectiveness of lycopene in IRI with biochemical and histopathological parameters and found that lycopene may have a protective effect on IRI. Kaya et al [28] also used high dose of lycopene (100 mg/kg) in a single dose in IRI of the kidney. They also used biochemical and histopathological parameters and mentioned that lycopene administered prior to renal IRI prevented renal damage.…”

Section: Discussionmentioning

confidence: 99%

Scintigraphic, histopathologic and biochemical evaluation of lycopene effects on renal ischemia reperfusion injury in rats

et al. 2017

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Introduction/Objective. Medical protection of kidneys against ischemia reperfusion injury is very important. Many agents have been used for the protection of ischemia reperfusion renal tissue injury. We aimed to evaluate the radioprotective effect of lycopene on kidneys in ischemia reperfusion injury with histopathological, biochemical, and scintigraphic parameters. Methods. Twenty-one Wistar male albino rats were divided into the following three groups: lycopene, control, and sham group. In the lycopene group, lycopene was started three days before right renal ischemia reperfusion injury and continued for 15 days. In the control group, right renal ischemia reperfusion injury was applied with no medication. In the sham group, neither right renal ischemia reperfusion injury nor medication were applied. On the 15th day, all rats were sacrificed after 99mTc-dimercaptosuccinic acid (DMSA) scintigraphies were taken. Histopathological, biochemical, and scintigraphic evaluations were made. Results. The histopathological score was lower in the lycopene group. In biochemical analysis, myeloperoxidase levels were lower in the lycopene group than in the control group, but not statistically significant. Malondialdehyde and nitrite levels were lower in the lycopene group than in the control group. The postoperative mean 99mTc-DMSA uptake values were 44.82 ? 1.84 in the lycopene group, 38.92 ? 1.17 in the control group, and 50.21 ? 1.35 in the sham group. DMSA uptake values were higher in the lycopene group than in the control group. Conclusion. Lycopene seems to be an effective agent for protection of kidneys in ischemia reperfusion injury as demonstrated by the histopathological, biochemical, and scintigraphic parameters.

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“…In AKI there is an activation of wide range of inflammatory responses, mainly driven by the local oxidative stress and lipid peroxidation [20]. Previous studies showed that lycopene possess anti-carcinogenic, anti-inflammatory and antioxidant effects, therefore, this study investigated its beneficial supplementation in AKI cases in mice model [21]. Although blood urea nitrogen and serum creatinine were significantly increased in the control study group as compared to the sham group, lycopene supplementation appears to have a protective effect against further renal tissue damage.…”

Section: Discussionmentioning

confidence: 98%

The Nephroprotective Effect of Lycopene on Renal Ischemic Reperfusion Injury: A Mouse Model

et al. 2019

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Acute kidney injury (AKI) is characterized by fast decline in renal function within a short period of time. Renal ischemic-reperfusion (I-R) injury is the main cause of AKI. This study aims to investigate the possible nephroprotective effect of lycopene on renal ischemicreperfusion injury in mice model. Forty Swiss Albino adult male mice were randomly allocated onto one of the four study groups: sham group: mice had median laparotomy under anesthesia with no procedures performed, renal tissues and blood samples were collected. ischemic-reperfusion group (I-R-control): mice underwent median laparotomy under anesthesia, followed by 30 min bilateral renal ischemia. Renal tissues and blood samples were collected after 2 h from reperfusion. Vehicle-treated group: mice were pretreated with intra 1% dimethyl sulfoxide 30 min before inducing ischemia. Lycopene-treated group: mice were pretreated with 10 mg/kg intraperitoneal injection of lycopene 30 min before inducing renal ischemia. Renal tissues, and blood samples were collected after 2 h from reperfusion. Blood and tissue samples were collected to look for evidence of inflammation and necrosis. Blood urea nitrogen, serum creatinine as well as plasma NGAL levels were significantly increased in the active control group (P B 0.05), when compared to the sham group. Similarly, renal levels of Notch2/Hes 1, TLR 2, IL-6, Bax, and F2-isoprostane were significantly increased in the active control group as compared to the sham group (P B 0.05). Moreover, lycopene treatment was found to be significantly effective in reducing the increased levels of these markers after I-R injury (P B 0.05).

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Lycopene has reduced renal damage histopathologically and biochemically in experimental renal ischemia-reperfusion injury

Abstract: The present study demonstrated that lycopene, which was administered prior to renal I/R injury, prevented renal damage through biochemical and histopathological parameters.

Cited by 25 publications

References 37 publications

Histological and Immunohistochemical Study of Titanium Dioxide Nanoparticle Effect on the Rat Renal Cortex and the Possible Protective Role of Lycopene

Histological and Immunohistochemical Study of Titanium Dioxide Nanoparticle Effect on the Rat Renal Cortex and the Possible Protective Role of Lycopene

Scintigraphic, histopathologic and biochemical evaluation of lycopene effects on renal ischemia reperfusion injury in rats

The Nephroprotective Effect of Lycopene on Renal Ischemic Reperfusion Injury: A Mouse Model

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