Acute kidney injury (AKI) is characterized by fast decline in renal function within a short period of time. Renal ischemic-reperfusion (I-R) injury is the main cause of AKI. This study aims to investigate the possible nephroprotective effect of lycopene on renal ischemicreperfusion injury in mice model. Forty Swiss Albino adult male mice were randomly allocated onto one of the four study groups: sham group: mice had median laparotomy under anesthesia with no procedures performed, renal tissues and blood samples were collected. ischemic-reperfusion group (I-R-control): mice underwent median laparotomy under anesthesia, followed by 30 min bilateral renal ischemia. Renal tissues and blood samples were collected after 2 h from reperfusion. Vehicle-treated group: mice were pretreated with intra 1% dimethyl sulfoxide 30 min before inducing ischemia. Lycopene-treated group: mice were pretreated with 10 mg/kg intraperitoneal injection of lycopene 30 min before inducing renal ischemia. Renal tissues, and blood samples were collected after 2 h from reperfusion. Blood and tissue samples were collected to look for evidence of inflammation and necrosis. Blood urea nitrogen, serum creatinine as well as plasma NGAL levels were significantly increased in the active control group (P B 0.05), when compared to the sham group. Similarly, renal levels of Notch2/Hes 1, TLR 2, IL-6, Bax, and F2-isoprostane were significantly increased in the active control group as compared to the sham group (P B 0.05). Moreover, lycopene treatment was found to be significantly effective in reducing the increased levels of these markers after I-R injury (P B 0.05).

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Through the current research, a study of the nuclear composition and the form of even isotones movements – those of the even atomic weight between 178 – 188, after specifying the dynamic symmetry of each nucleus using the first prototype of the interactive bosons (IBM-1), the intrinsic values as well as the intrinsic vectors were calculated using the (IBM-code) program.It also calculated the probability of the quadrant-polar, electric movement that are B(E2) as well the quadrant-polar, electric torque (QL)using the (IBMT-code) program.The 130Ba isotope with 56 protons and 74 neutrons, has the number of bosons is 7 and the ratio R 4 1 + / 2 1 + is 2.5235, the levels 2 1 + , 4 1 + , 6 1 + , 8 1 + , 2 2 + , 0 2 + and 2 3 + , with energies 0.3574, 0.8914, 1.6021, 2.4894, 0.8971, 1.1795and1.5369 MeV are in good agreement comparing with the experimental energy. The level 4 3 + , with energy 2 0709MeV compared with the energy experimental 2.0537 MeV. So, this level confirmed in the present work. The levels 10 1 + , 12 1 + , 3 1 + , 4 2 + , 5 1 + , 6 2 + and 8 2 + , with energies 3.5534, 3.5534, 1.6143, 1.6111, 2.5065, 2.5016 and 3.5689 MeV, respectively correspond to cases for which the angular momentum and/or parity of the corresponding states are not well established experimentally. The calculations have been predicted new levels with energies 3.5754, 2 7816.and 3.6689MeV for the angular momentum and parity 7 1 + , 6 3 + and 8 3 + , respectively. From the experimental value of transition B ( E 2 ; 2 1 + → 0 1 + ) , the value of parameter eB (α2) have been calculated for 130Ba isotope and The comparison for 130Ba isotope under study. There is no available experimental transition data to many transitions, Therefore, it has been predicted using IBM-1. In this study, there are a good agreement between the experimental B(E2) values and the IBM-1 calculated generally.

Objective Pulmonary hypertension has been described as an elevation in mean pulmonary artery pressure (PAP) >25 mmHg at rest or 30 mmHg during exercise, which can be classified into primary and secondary pulmonary hypertension.Methods In this study, subjects were divided into two groups of patients and controls. The patients were treated with Sildenafil for 3 months, starting with 0.2 mg/kg/dose, six times daily and then the dose was increased with an increment of 0.2 mg/kg/dose every 15 days. Echocardiography examination, including pulmonary artery pressure, tricuspid regurgitation velocity, and pulmonary artery acceleration time, as well as oxygen saturation (SpO2) rate were measured every 15 days.Results The results revealed that a significant decrease (P < 0.05) in the pulmonary artery and tricuspid pressure, and a significant increase (P < 0.05) in the rate of blood oxygen saturation and pulmonary artery acceleration time have been found.Conclusion The results of this study reveal that Sildenafil has a great effect in the treatment of the secondary type of pulmonary hypertension and has a negligible effect on primary pulmonary hypertension.