Lycopene protects against central and peripheral neuropathy by inhibiting oxaliplatin-induced ATF-6 pathway, apoptosis, inflammation and oxidative stress in brains and sciatic tissues of rats

Çelik, Hamit; Küçükler, Sefa; Özdemir, Selçuk; Çomaklı, Selim; Gür, Cihan; Kandemir, Fatih Mehmet; Yardım, Ahmet

doi:10.1016/j.neuro.2020.06.005

Cited by 52 publications

(46 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Compared to the control group, the increased NF-κB levels and decreased Nrf2 levels in our findings revealed the relationship between these two molecules in ASD. However, in many studies, it has been reported that lycopene application could decrease the increased NF-κB activations and increase the decreased Nrf2 levels (Celik et al, 2020;Sahin et al, 2018). Also, there was no change in NF-κB level in the present study depending on the dose, while an increase in Nrf2 level was observed.…”

Section: Discussioncontrasting

confidence: 73%

“…PPA stimulates polyunsaturated fatty acid oxidation and produces MDA that forms the biomolecular damage in the current study. Previous studies suggested lycopene to be a powerful antioxidant due to its many conjugated double bonds, reducing lipid peroxidation by decreasing the MDA levels (Celik et al, 2020;Dogukan et al, 2011;Zhu et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lycopene ameliorates propionic acid‐induced autism spectrum disorders by inhibiting inflammation and oxidative stress in rats

Erten

2021

J Food Biochem

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Lycopene ameliorates propionic acid‐induced autism spectrum disorders by inhibiting inflammation and oxidative stress in rats

Erten

2021

J Food Biochem

View full text Add to dashboard Cite

show abstract

“…Apoptosis, programed cell death, occurs at certain limits in all tissues, including the testis (Celik, Kucukler, et al., 2020; Kandemir et al., 2020). However, the excessive occurrence of apoptosis in testicular tissues can lead to infertility in men due to some factors (Richburg, 2000).…”

Section: Discussionmentioning

confidence: 99%

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

et al. 2020

Self Cite

View full text Add to dashboard Cite

In the present study, the protective effects of chrysin (CHR) against testicular damage caused by lead acetate (PbAc) were examined. In this way, 30 min after rats were given 25 and 50 mg/kg/b.w CHR orally for seven consecutive days, 30 mg/kg/b.w PbAc was administered orally. In biochemical analysis of testicular tissue, it was found that PbAc-reduced antioxidant parameters [glutathione peroxidase (GPx), glu

show abstract

“…Our study focused on the effects of oxaliplatin and Cystine/Theanine on the peripheral nerve system. However, it has been reported that oxaliplatin enhances the oxidative stress in also the central nerve system, such as brain and spinal cord 38 – 43 . Theanine can cross the blood–brain barrier (BBB) via L-type amino acid transporter 1 (LAT1) and LAT2 44 , 45 .…”

Section: Discussionmentioning

confidence: 99%

Oral administration of Cystine and Theanine ameliorates oxaliplatin-induced chronic peripheral neuropathy in rodents

Kawashiri

Kobayashi

Egashira

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Oxaliplatin frequently causes severe peripheral neuropathy as a dose-limiting toxicity. However, this toxicity lacks a strategy for prevention. Cystine/Theanine is a supplement, which includes precursors for the biosynthesis of glutathione. In this study, we investigated the effects of Cystine/Theanine on oxaliplatin-induced peripheral neuropathy using an in vivo model. Repeated injection of oxaliplatin (4 mg/kg intraperitoneally twice a week for 2 weeks) caused mechanical allodynia, cold hyperalgesia and axonal degeneration of the sciatic nerve in rats. Mechanical allodynia and axonal degeneration, but not cold hyperalgesia, were ameliorated by daily co-administration of Cystine [200 mg/kg orally (p.o.)] and Theanine (80 mg/kg p.o.). Moreover, co-administration of Cystine and Theanine to rats significantly increased the glutathione level in the sciatic nerve compared with the oxaliplatin group. Furthermore, Cystine and Theanine did not attenuate the tumour cytotoxicity of oxaliplatin in C-26 tumour cell-bearing mice. These findings suggest that Cystine and Theanine may be beneficial for preventing oxaliplatin-induced peripheral neuropathy.

show abstract

Lycopene protects against central and peripheral neuropathy by inhibiting oxaliplatin-induced ATF-6 pathway, apoptosis, inflammation and oxidative stress in brains and sciatic tissues of rats

Cited by 52 publications

References 59 publications

Lycopene ameliorates propionic acid‐induced autism spectrum disorders by inhibiting inflammation and oxidative stress in rats

Lycopene ameliorates propionic acid‐induced autism spectrum disorders by inhibiting inflammation and oxidative stress in rats

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

Oral administration of Cystine and Theanine ameliorates oxaliplatin-induced chronic peripheral neuropathy in rodents

Contact Info

Product

Resources

About