Lyme Meningoradiculitis and Myositis after Allogeneic Hematopoietic Stem Cell Transplantation

Rodríguez, Martín; Chou, Sherry; Fisher, David C.; Girolami, Umberto De; Amato, Anthony A.; Marty, Francisco M.

doi:10.1086/498154

Cited by 10 publications

(3 citation statements)

References 16 publications

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“…infection in immunocompromised patients is very limited; as a consequence, neither the natural course nor the efficacy of treatment of Lyme borreliosis has been accurately assessed in this diverse group comprising several distinct types and severities of immunosuppression. Data in the literature are scant and predominantly restricted to individual case reports, such as a report on a B. burgdorferi infection in a patient with dermatomyositis [253] , a description of a morphea-like skin condition apparently caused by B. burgdorferi in an immunocompromised patient [254] , a case of Lyme borreliosis in a transplant recipient [255] and several cases of Lyme borreliosis in conjunction with human immune deficiency virus infection [256][257][258] . We were able to find only 3 reports on a series of cases of Lyme borreliosis in immunocompromised patients.…”

Section: Lyme Borreliosis In An Immunocompromised Hostmentioning

confidence: 99%

Clinical Manifestations and Diagnosis of Lyme Borreliosis

Strle

Stanek

2009

Current Problems in Dermatology

164

140

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Lyme borrelosis is a multi-systemic disease caused byBorrelia burgdorferisensu lato. A complete presentation of the disease is an extremely unusual oberservation, in which a skin lesion follows a tick bite, the lesion itself is followed by heart and nervous system involvement, and later on by arthritis; late involvement of the eye, nervous system, joints and skin may also occur. Information on the relative frequency of individual clinical manifestations of Lyme borreliosis is limited; however, the skin is most frequently involved and skin manifestations frequently represent clues for the diagnosis. The only sign that enables a reliable clinical diagnoisis of Lyme borreliosis is a typical erythema migrans. Laboratory confirmation of a borrelial infection is needed for all manifestations of Lyme borreliosis, with the exception of typical skin lesions.

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Section: Lyme Borreliosis In An Immunocompromised Hostmentioning

confidence: 99%

Clinical Manifestations and Diagnosis of Lyme Borreliosis

Strle

Stanek

2009

Current Problems in Dermatology

164

140

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“…Rickettsia rickettsii infection (Rocky Mountain spotted fever) has been described after heart transplantation [55], and Rickettsia conorii infection has been reported after liver transplantation [56]. Borrelia burgdorferi infection (Lyme disease) has been described in the literature in transplant recipients, including 1 kidney transplant recipient [14], 1 heart transplant recipient (with carditis) [15], and 1 allogeneic hematopoietic stem cell transplant recipient [16].…”

Section: Bacterial Infectionmentioning

confidence: 99%

Zoonoses in Solid-Organ and Hematopoietic Stem Cell Transplant Recipients

Kotton

2007

Clinical Infectious Diseases

139

105

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Numerous reports exist of the transmission of zoonoses to humans during and after solid-organ and hematopoietic stem cell transplantation. Donor-derived infections of numerous etiologies, including West Nile virus infection, Chagas disease, toxoplasmosis, rabies, lymphocytic choriomeningitis virus infection, and infection due to Brucella species have been reported. Most zoonoses occur as a primary infection after transplantation, and immunocompromised patients are more likely to experience significant morbidity and mortality from these infections. Risks of zoonotic infection in the posttransplantation period could be reduced by patient education. Increased recognition of the risks of zoonoses, as well as the advent of molecular biology-based testing, will potentially augment diagnostic aptitude. Documented zoonotic infection as it affects transplantation will be the primary focus of this review.

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“…Medline searches for cases of Lyme disease or ehrlichiosis in transplant recipients reported in the English literature from 1971 to 2005 revealed 3 cases of Lyme disease (Table 1), 6 cases of HGA (Table 2), and 5 cases of HME (Table 3) in adult patients (10–19). The current case reported herein is included in Tables 1 and 2 for comparison.…”

Section: Literature Reviewmentioning

confidence: 99%

Lyme disease followed by human granulocytic anaplasmosis in a kidney transplant recipient

Assi

Yao

Walker

2007

Transplant Infectious Dis

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We report the case of a kidney transplant recipient who developed Lyme disease, followed by human granulocytic anaplasmosis (HGA) 3 years later. A review of all previously published cases of Lyme disease (3 cases), HGA (5 cases), and human monocytic ehrlichiosis (HME) (5 cases) in transplant recipients is presented. Manifestations of the cases reviewed were similar to those of non-transplant patients. There appeared to be no obvious correlation between immunosuppression and the occurrence of the illness in the transplant recipients. Serologic testing failed to make a diagnosis in 1 patient with HME in the literature and in our patient with HGA, but molecular tests established the diagnosis in both cases. Tandem infection was observed in 1 patient with two episodes of HME 2 years apart. A high index of suspicion for tick-borne illnesses and appropriate prevention measures are needed for transplant patients with epidemiologic risk factors.

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Lyme Meningoradiculitis and Myositis after Allogeneic Hematopoietic Stem Cell Transplantation

Cited by 10 publications

References 16 publications

Clinical Manifestations and Diagnosis of Lyme Borreliosis

Clinical Manifestations and Diagnosis of Lyme Borreliosis

Zoonoses in Solid-Organ and Hematopoietic Stem Cell Transplant Recipients

Lyme disease followed by human granulocytic anaplasmosis in a kidney transplant recipient

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