Lymphocyte DNA damage in patients with acute coronary syndrome and its relationship with severity of acute coronary syndrome

Demirbağ, Recep; Yılmaz, Remzi; Gür, Mustafa; Koçyiğit, Abdürrahim; Çelik, Hakim; Güzel, Salih; Selek, Sahabettın

doi:10.1016/j.mrfmmm.2005.05.005

Cited by 43 publications

(22 citation statements)

References 42 publications

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“…Thus, in patients with SAP, the evaluation of the TAS levels in conjunction with lymphocyte DNA damage may better delineate the protective status of the patients against oxidative stress. The absence of significant TOS levels in correlation with TAS and lymphocyte DNA damage levels support the finding in the literature that different oxidative stress factors with different anti-oxidant capacity may function in distinct inflammatory conditions (20,21). The reflection of oxidative status in AP with the findings of reduced TAS levels and severity of lymphocyte DNA damage and severity of AP in the early stages are the two main important finding in our study.…”

Section: Discussionsupporting

confidence: 91%

Oxidative status and lymphocyte DNA damage in patients with acute pancreatitis and its relationship with severity of acute pancreatitis

Dur¹,

Kocaman²,

Koçyiğit³

et al. 2016

Turk J Gastroenterol

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Section: Discussionsupporting

confidence: 91%

Oxidative status and lymphocyte DNA damage in patients with acute pancreatitis and its relationship with severity of acute pancreatitis

Dur¹,

Kocaman²,

Koçyiğit³

et al. 2016

Turk J Gastroenterol

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“…In a previous study Demirbag et al [37] using alkaline Comet assay have demonstrated an increase in DNA damage in obese patients with respect to non-obese ones, stating that the obesity may be considered as a risk factor independent of DNA damage. Our results above all confirm the existence of an increase in DNA damage in both NWO and OB women, with respect to control subjects, probably sustained by inflammatory status too.…”

Section: Discussionmentioning

confidence: 97%

DNA damage in normal-weight obese syndrome measured by Comet assay

Tomasello

Malfa

Galvano

et al. 2010

Mediterr J Nutr Metab

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New roles have been discovered for the adipose mass/tissue of obese subjects linked to the production of different cytokines, leptin and oxidative stress, all together playing a crucial role in developing obesity, insulin resistance, metabolic syndrome, and the pathogenesis of various diseases. Inflammatory status and plasma oxidative stress have been reported as also characterizing a new metabolic condition known as normal-weight obese (NWO) syndrome observed in women with normal index but fat mass (FM) [30%. The aim of the present study was to investigate in NWO women, compared with preobese-obese (OB) and control normal weight (NW) subjects, the occurrence of DNA damage, particularly oxidative DNA damage, by using different Comet assay versions. Our goal was to find out some possible new early hallmarks of obesity. We observed above all increase in DNA damage both in OB and NWO women, compared with NW subjects, underlining DNA to be involved in oxidative stress related to metabolic abnormalities occurring in obesity. In addition, the use of either pH [13 versus pH 12.1 alkaline Comet assay versions or pH 12.1 in presence of Fpg enzyme versus pH 12.1 alone, allow us to draw attention to two possible new early differentiated hallmarks: first, alkali labile sites higher in OB compared to NWO; second, 8-oxo-dG level slightly higher in NWO than in OB women. These preliminary results encourage planning broad cohort studies in order to verify and validate these hypothesized predictive/prognostic new hallmarks.

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“…Second, collateral circulation to the microvascular bed will be insufficient if the donor artery is also diseased. Third, oxidative stress is increased in acute coronary syndrome with the severity of coronary artery disease, whereas oxidant stress reduces the vasodilatatory effects of nitric oxide, adenosine, and prostacyclin [23][24][25]. Interestingly, there were fewer smokers in the patient group with MBG 0/1.…”

Section: Discussionmentioning

confidence: 98%

Does SYNTAX score II predict poor myocardial perfusion in ST-segmen

Wang

Hua

et al. 2016

Cardiol J.

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(£ 20), and SS-II high (≥ 26). MBG 0/1 (46.1%, 32.1% and 21.8%, p < 0.001, respectively). On multivariate logistic regression analysis, SS-II was an independent predictor of MBG 0/1 (hazard ratio 1.084, 95% confidence interval 1.050-1.119, p < 0.001). Receiver operating characteristic analysis identified SS-II > 24 as the best cut-off value predicting MBG 0/1 (sensitivity of 66%, specificity of 54%). STEMI undergoing pPCI. (Cardiol J 2016; 23, 3: 317-323) Results: Compared with the SS-II intermediate and SS-II low tertiles, the SS-II high tertile had more Conclusions: High SS-II is an independent predictor of MBG 0/1 in patients with

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Lymphocyte DNA damage in patients with acute coronary syndrome and its relationship with severity of acute coronary syndrome

Cited by 43 publications

References 42 publications

Oxidative status and lymphocyte DNA damage in patients with acute pancreatitis and its relationship with severity of acute pancreatitis

Oxidative status and lymphocyte DNA damage in patients with acute pancreatitis and its relationship with severity of acute pancreatitis

DNA damage in normal-weight obese syndrome measured by Comet assay

Does SYNTAX score II predict poor myocardial perfusion in ST-segmen

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