Lymphocyte subpopulation changes by aging

Bátory, Gabriella; Beregi, E; Petrányi, G

doi:10.1016/0167-4943(82)90013-9

Cited by 4 publications

(2 citation statements)

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“…These immune differences between young and aged people may represent some aspects of the complex and constant remodeling of the immune system with advancing age, and contribute with a proinflammatory profile. Among the variations already found and consistent with our results is a high TNF-α concentration detected in the plasma from the elderly [2,37,38], which may be related to the development of acute and chronic inflammatory conditions, carcinogenesis, and autoimmune diseases [1,12-14]. Irrespective of age, the TNF-α dysregulation could be associated to several diseases, such as diabetes type II, rheumatoid arthritis and atherosclerosis, among others [39].…”

Section: Discussionsupporting

confidence: 90%

“…In vitro experiments have shown that absence of the enzyme telomerase leading to critical shortening of the protective ends of chromosomes plays a central role in human cell senescence [10,11]. These changes in immunosenescence are related to various impairments such as susceptibility to inflammatory, infectious and autoimmune diseases, as well as increasing rates of occurrence of malignancies [1,12-14]. Although these diseases are usually easily resolved clinically, elderly humans suffer from complications caused by the individual's altered response [1].…”

Section: Introductionmentioning

confidence: 99%

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Proinflammatory profile of in vitro monocytes in the ageing is affected by lymphocytes presence

et al. 2013

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BackgroundAging is associated with complex and constant remodeling of the immune function, resulting in an increasing susceptibility to infection and others diseases. The infections caused by Gram-negative microorganisms, present in nursing homes and hospitals, constitute one of the most common infections in the elderly, and are mainly combated by innate immune cells. Although the functions of innate immunity seem more preserved during aging than of adaptive immune mechanisms, two systems operate in an integrated way in the body, so that injury in one part of the immune system inevitably affects the other as they are part of a defensive network. The aim of this study was to investigate the in vitro production of proinflammatory (TNF-α, IL-6, IL-1β, CXCL-8 and MCP-1) and anti-inflammatory (TGF-β and IL-10) cytokines by monocytes, stimulated or not (basal) with lipopolysaccharide, from healthy young and elderly subjects. By means of PBMCs, we also studied if cytokine profile is altered in these different patient groups, in the presence of lymphocytes, under the same experimental conditions.ResultsThe monocytes from elderly presented higher basal production of TNF-α, MCP-1 and lower of TGF-β than young monocytes. PBMC showed similar cytokines production, irrespective age or stimulation presence. In the presence of lymphocytes, the spontaneous production of IL-10 was higher and of TGF-β was lower than monocytes, regardless of age. After LPS-stimulation, the presence of lymphocytes resulted in increased IL-6, IL-1β, MCP-1 and IL-10 and decreased CXCL-8 and TGF-β in comparison to pure culture of monocytes from young patients. With age, the same differences were observed, except for CXCL-8 and TGF-β which production was the same between monocytes and PBMC stimulated with LPS.ConclusionThese findings reinforce the systemic state of inflamm-aging frequently reported in elderly and considered a factor of susceptibility to numerous diseases. Still, the cytokine production from just monocytes of the elderly showed alterations, while in the lymphocyte presence not, suggesting an immunomodulator role of lymphocytes on monocytes. In addition, the differences between the production patterns by LPS-stimulated PBMC between young and elderly volunteers can be related with an imbalance in response against Gram-negative bacteria in throughout life.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Proinflammatory profile of in vitro monocytes in the ageing is affected by lymphocytes presence

et al. 2013

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Age related variations of some polymorphonuclear leukocyte functions

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et al. 1985

Mechanisms of Ageing and Development

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Background: The casual and severity distribution of allergic rhinitis (AR) in Hungary is unknown. The aim of this survey was to evaluate symptom perception, disease severity, concomitant asthma frequency and the impact of AR on everyday life activities in a cross-sectional, multicenter study in Hungary under the supervision of Hungarian Respiratory Society. Methods: Data were recorded by 933 AR patients (65.93% women) and their treating specialists. The perceptions of patients regarding the symptoms (nasal, ocular and others) of AR and its severity, together with its impact on everyday life were assessed. Physicians recorded data regarding the diagnosis and severity of AR, and comorbidities.

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