Lymphoepithelial lesions of salivary glands. Histogenesis and classification based on 186 cases

Bernier, Joseph L.; Bhaskar, Surindar N.

doi:10.1002/1097-0142(195811/12)11:6<1156::aid-cncr2820110611>3.0.co;2-2

Cited by 201 publications

(56 citation statements)

References 12 publications

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“…A review of the literature identified several pathologic series from the 1950s that commented on the indolent histologic appearance of these tumors, which is characterized by its low mitotic index and large proportion of noncycling cells. [10][11][12] In the subsequent decades, isolated reports of late recurrences after treatment for salivary gland cancer appeared, with authors suggesting that this disease has the ability to recur after a prolonged period. 5,7,8,[13][14][15] The results of several more recently published single institutional experiences support this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Late recurrence from salivary gland cancer

Chen

García

Granchi

et al. 2007

Cancer

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BACKGROUND.The purpose of the current study was to determine the incidence of late recurrences, which were defined as those occurring ≥5 years after initial therapy, among patients treated for salivary gland cancer.METHODS.Between 1960 and 2000, 145 patients underwent definitive therapy for localized carcinomas of the salivary glands and were clinically without evidence of disease at 5 years of follow‐up. Cumulative probabilities for developing a subsequent late recurrence were estimated using the Kaplan‐Meier method.RESULTS.The 10‐year and 15‐year cumulative probabilities of late recurrence in patients who were free of disease at 5 years were 13% and 18%, respectively. The crude rates of late recurrence by histologic subtype were adenoid cystic carcinoma (26%), mixed malignant tumor (25%), mucoepidermoid carcinoma (17%), adenocarcinoma (10%), and acinic cell carcinoma (8%). Sites of late recurrence included distant metastasis (17 patients), local recurrence (8 patients), and regional recurrence (2 patients). The median time to late recurrence was 7.1 years (range, 5.2–23.1 years) from the date of initial surgery. Salvage treatment varied according to location of disease recurrence and initial treatment characteristics. The 15‐year estimate of overall survival was 39% for patients who experienced a late recurrence compared with 71% for those who remained free of disease (P = .001).CONCLUSIONS.A significant proportion of patients who are presumed to be cured of their disease at 5 years after initial treatment for salivary gland cancer will be found to develop late disease recurrence with additional follow‐up. Cancer 2008. © 2007 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Late recurrence from salivary gland cancer

Chen

García

Granchi

et al. 2007

Cancer

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“…The similarity of the histology of these two entities and their shared affinity for the parotid gland raise the possibility that they are different manifestations of the same lesion. Bernier et al [3] indicated that cyst could form in the diffuse type of benign lymphoepithelial lesion, although they considered that this cyst was different from lymphoepithelial cyst. However, they did not give much explanation for such a conclusion even though both conditions were thought to be reactive in nature.…”

Section: Proposed Histogenesismentioning

confidence: 99%

“…Both lymphoepithelial cyst and lymphoepithelial lesion are histologically characterized by an epithelial and a lymphoid component. Both entities are believed to originate from heterotopic salivary epithelial rests or inclusions in either intra-or peri-parotid lymphoid tissue [3,4]. Although malignant transformation of lymphoepithelial lesion in the parotid glands into lymphoma [5,6], or into carcinoma has been well documented [7,8], squamous cell carcinoma of parotid gland associated with concurrent lymphoepithelial cyst and lymphoepithelial lesion has not been described.…”

Section: Introductionmentioning

confidence: 99%

Squamous Cell Carcinoma of Parotid Gland Associated with Concurrent Lymphoepithelial Cysts and Lymphoepithelial Lesion: Case Report and Proposed Histogenesis

Zhou

Holsinger

2014

Head and Neck Pathol

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Lymphoepithelial cyst and lymphoepithelial lesion have similar histologic features and an affinity for the parotid gland. Though considered as different entities, both conditions arise from heterotopic salivary epithelial rests or inclusions in intra-or peri-parotid lymph nodes. We present a case of squamous cell carcinoma of parotid gland associated with concurrent lymphoepithelial cyst and lymphoepithelial lesion in a patient who was not infected with human immunodeficiency virus. We propose that lymphoepithelial cyst and lymphoepithelial lesion have a similar histogenesis.

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“…[3] The term "lymphoepithelial cyst" was denominated by Bernier and Bhaskar to lay emphasis on the non-embryonic derivation of this lesion. [4] These cysts are usually seen inhuman immunodeficiency virus (HIV) positive individuals and their rise in incidence has coincided with that of HIV infection, occasionally as the first manifestation of retroviral infection. [5,6] However, they have also been seen in HIV negative individuals, although less frequently, thereby making its pathogenesis elusive with respect to HIV.…”

Section: Introductionmentioning

confidence: 99%

Benign lymphoepithelial cyst in an adolescent female mimicking lymphoma: A diagnostic dilemma in a retrovirus negative patient

Chowdhury

Zaheer²,

Sharma

et al. 2017

APALM

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Cystic lesions of the parotid gland are uncommon and may masqueradeneoplasms clinically. Benign lympho-epithelial cysts (BLEC) comprise the most common causes of the parotid gland swelling in human immunodeficiency virus (HIV)-positive patients. It is, however, less common amongst those not infected with HIV. We present a case of a12 years old female who presented with a swelling over left parotid region since one year.Local examination revealed a soft, cystic and non-tender swelling in the left parotid region measuring 5x4x3 cm. Serological investigations for viral markers were non-reactive.A differential diagnosis of granulomatous parotitis versus benign lymphoepithelial lesion was rendered on radiological investigations and superficial parotidectomy was planned. On histopathological examination, a cyst lined by cuboidal to low columnar lining was seen, underlying which, was dense lympho-plasmacytic infiltrate present in diffuse sheets. On immunohistochemistry, this lymphoid population was found to be reactive in nature (positive for kappa and lambda), thus excluding lymphoma. This case is being presented due to its rarity in HIV negative individuals and the histopathological diagnostic dilemma it presented with, mimicking a lymphoma.

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Lymphoepithelial lesions of salivary glands. Histogenesis and classification based on 186 cases

Cited by 201 publications

References 12 publications

Late recurrence from salivary gland cancer

Late recurrence from salivary gland cancer

Squamous Cell Carcinoma of Parotid Gland Associated with Concurrent Lymphoepithelial Cysts and Lymphoepithelial Lesion: Case Report and Proposed Histogenesis

Benign lymphoepithelial cyst in an adolescent female mimicking lymphoma: A diagnostic dilemma in a retrovirus negative patient

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