Lymphoepithelioma-Like Carcinoma of the Urinary Bladder: Report of a Rare Case

Singh, Naorem Gopendro; Mannan, Abul Ala Syed Rifat; Rifaat, Amre A.; Kahvic, Mirza

doi:10.5144/0256-4947.2009.478

Cited by 4 publications

(6 citation statements)

References 13 publications

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“…4 Histological features of LELC closely resemble nasopharyngeal lymphoepithelioma, with the tumor growing in the nests, sheets, or cords of large undifferentiated malignant epithelial cells in the background of dense inflammatory infiltrate comprising mainly lymphocytes, plasma cells, and a few eosinophils and neutrophils. 1 Amin et al categorized LELC of the urinary bladder into three subgroups based on lymphoepithelioma component: pure (100%), predominant (> 50%), and focal (< 50%). These subgroups significantly determine the prognosis as disease-free survival is higher in pure and predominant LELCB than in mixed type.…”

Section: Discussionmentioning

confidence: 99%

“…Carcinomas with similar histological features arising outside the nasopharynx are known as LELC, which have been reported in various organs such as the thymus, cervix, and salivary glands. 1 Involvement of urinary bladder was first reported by Zukerberg et al in 1991 with a reported incidence between 0.4% and 1.3% of all bladder carcinomas. 2 It has been categorized into three subgroups: pure (100% lymphoepithelioma component), predominant (between 50% and 100%), and focal (< 50%).…”

Section: Introductionmentioning

confidence: 96%

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Lymphoepithelioma-Like Carcinoma of Urinary Bladder with Diagnostic Dilemma: Case Report of a Rare Variant of Urothelial Carcinoma

et al. 2021

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Lymphoepithelioma-like carcinoma of the urinary bladder is a rare variant of urothelial carcinoma that was first described by Zukerberg in 1991 and confirmed as a type of urothelial carcinoma by the WHO classification of the urinary system tumors. A 63-year-old man presented with the chief complaint of gross hematuria for 2 months. Sections from transurethral resection of the bladder revealed urothelial carcinoma. A radical cystoprostatectomy was performed and a final histopathological examination revealed high-grade muscle-invasive urothelial carcinoma, lymphoepithelial variant. The patient has been receiving adjuvant chemotherapy with no recurrence reported to date. This is the third case reported in India to date to the best of our knowledge. Owing to its rare presentation, no definite treatment guidelines have been established for this entity. Various studies from the English literature suggest a conservative approach.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Lymphoepithelioma-Like Carcinoma of Urinary Bladder with Diagnostic Dilemma: Case Report of a Rare Variant of Urothelial Carcinoma

et al. 2021

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“…In mixed cases of urinary bladder carcinomas and LELCs, the more the presence of lymphoepithelioma-like elements, the less the risk of death from the disease. More precisely, a 5-year survival rate of 59% was reported for the predominant type while that of the pure type achieves 62% (7). Favourable prognosis along with response to chemotherapy provides a potential to salvage bladder function in patients with locally advanced LELC.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-like carcinoma of the bladder: A case report.

Stamatiou

Christopoulos

Tsavari

et al. 2016

Arch Ital Urol Androl

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Lymphoepithelioma is a rare histological type of low differentiated carcinoma of the nasopharyngeal region characterized by marked infiltration of lymphocytes in the area involved by tumor. However, carcinomas with this peculiar morphologic feature have been also described in various anatomic locations and they are generally designated «lymphoepithelioma-like carcinomas». Those of the urinary bladder are uncommon as they account of 0.4%-1.3% of all bladder carcinomas. They may coexist with the conventional urothelial carcinoma. Given their rarity, there is poor information regarding their behaviour. Here we present a new case of lymphoepithelioma-like carcinoma in the bladder and we discuss its characteristics and prognosis.

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“…A total of 60 patients diagnosed with LELCB with a median age of 69.5 (interquartile range: 61-75 years) were identified in the SEER database from 1999 to December 2015. LR was performed, and 95 cases from 28 published articles in English from 1993 to 2021 were extracted to verify the performance of prognostic classification derived from the SEER cohort (Supplementary Figure 1) (2,9,10,(12)(13)(14)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). The baseline characteristics, including age, gender, radiation therapy, tumor extent, and surgery approaches, were statistically similar in both data sets, except for the administration of chemotherapy (Table 1).…”

Section: Patient Characteristicsmentioning

confidence: 99%

Survival Analysis of Lymphoepithelioma-Like Carcinoma of the Urinary Bladder and the Effect of Surgical Treatment Modalities on Prognosis

Shou

Wang

2021

Front. Surg.

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Purpose: This study aimed to investigate the prognostic factors of patients with lymphoepithelioma-like carcinoma of the urinary bladder (LELCB) and explore the value of surgical treatment.Methods: Data of patients with LELCB were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The multivariate analysis was performed using the stepwise Cox proportional hazards regression model and conditional inference tree method to identify significant prognosticators of overall survival (OS) from the parameters such as age, gender, lymph node involvement, tumor extent, radiation, chemotherapy, and surgery type. Literature review (LR) was performed, and eligible cases were used to validate prognostic classification using the Kaplan–Meier method with log-rank tests.Results: Sixty patients with a median age of 69.5 years were identified from the SEER database and 91 patients through LR. The Cox analysis identified age, gender, lymph node involvement, and surgical approach as independent prognosticators of OS. Based on the nomogram scores, patients were stratified into three prognostic groups: (I) patients younger than 70 years; (II) patients older than 70 years, who received bladder-sparing therapy (BST); and (III) patients older than 70 years undergoing radical cystectomy (RC). Patients in group II had the worst outcomes in terms of OS compared with patients in groups I and III (p < 0.001 and p = 0.03, respectively). A similar survival pattern was found in the LR cohort.Conclusion: The nomogram provided individualized prognostic quantification of OS in patients with LELCB. BST could yield favorable outcomes when treating LELCB, especially for younger patients, whereas older patients might derive more survival benefit from RC.

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Lymphoepithelioma-Like Carcinoma of the Urinary Bladder: Report of a Rare Case

Cited by 4 publications

References 13 publications

Lymphoepithelioma-Like Carcinoma of Urinary Bladder with Diagnostic Dilemma: Case Report of a Rare Variant of Urothelial Carcinoma

Lymphoepithelioma-Like Carcinoma of Urinary Bladder with Diagnostic Dilemma: Case Report of a Rare Variant of Urothelial Carcinoma

Lymphoepithelioma-like carcinoma of the bladder: A case report.

Survival Analysis of Lymphoepithelioma-Like Carcinoma of the Urinary Bladder and the Effect of Surgical Treatment Modalities on Prognosis

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