Lymphoma of the Stomach

Welborn, J. Keith

doi:10.1001/archsurg.1965.01320100024005

Cited by 24 publications

(2 citation statements)

References 6 publications

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“…Cardiaresection, a procedure with a high mortality rate in older patients, is then necessary only if the lesion is cancerous; otherwise, chemotherapy or radiation therapy is the treatment of choice. The prognosis of operated or radiated lymphosarcoma is good and the five-year survival rate higher than that for gastric cancer (23). The size of the lesion of a malignant lymphoma, however, appears to be of more prognostic significance than the limitation to the mucosa and submucosa.…”

Section: Discussionmentioning

confidence: 95%

“…The term lymphosarcoma" was introduced by Virchow in 1863 (22). Compared to carcinoma, gastric lymphosarcoma is rare; according to W elborn et al (23), only 2,5% of all malignant gastric neoplasms were lymphosarcomas, although 40-500/ of the sarcomas of the entire gastrointestinal tract are of this type (7). The lesions are usually single rather than multicentric, but multiple foci do occur.…”

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confidence: 99%

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Gastric Lymphosarcoma Limited to the Mucosa and Submucosa Simulating the Macroscopical Appearance of Early Cancer Type II c

Seifert¹,

Braschke²,

Glatzel³

et al. 1974

Endoscopy

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Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

Gastric Lymphosarcoma Limited to the Mucosa and Submucosa Simulating the Macroscopical Appearance of Early Cancer Type II c

Seifert¹,

Braschke²,

Glatzel³

et al. 1974

Endoscopy

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Extramedullary plasmacytoma of stomach

Remigio

Klaum

1971

Cancer

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A case report and an analysis of 12 additional reported cases of plasmacytoma of the stomach are presented. No specific clinical or laboratory findings characterized this disease. Grossly, the lesions resembled carcinoma and are classified as nodular, infiltrative, ulcerative, and polypoid. Like lymphoma, it may present a multinodular pattern with multiple ulcerations in roentgenograms. Surgery is the therapy of choice, followed by radiation. For disseminated Iesions, radiation and/or chemotherapy produce tumor regression. Plasmacytoma involved small and/or large intestines in 5 cases; esophagus was never invohed. Ten patients died in 5 years-6 of gastric plasmacytoma, 4 of postoperative complications. Five cases had disseminations; 2 showed bone involvement.LASMA CELL NEOPLASMS ARE USUALLY CLASSI-P fied as multiple myeloma when tumors are dispersed in the skeletal system; solitary myeloma or plasmacytoma when they appear as a single focus in a bone; extramedullary plasmacytoma when they involve extraosseous structures; and, plasma cell leukemia when abnormal plasmacytes invade the peripheral blood. Hellwigs reviewed 127 published cases of extramedullary plasmacytoma in 1943; he found the upper respiratory tract as the most common site, followed by the conjunctiva. Occurrences in the gastrointestinal tract and thyroid were extremely sparse. Plasmacytomas of the conjunctiva were found to be benign, frequently associated with trachoma, and occurring in young females, whereas, those found in the upper respiratory tract were malignant in about 50y0 of instances. Hellwigs emphasized the inconsistent correlation of the cytologic differentiation of the tumor with its clinical behavior. H e established as his criteria for malignancy destructive changes of surrounding tissues and metastases to lymph nodes and/or bone(s). In 1928, Vasiliu reported 3 patients with extramedullary plasmacytoma of the gastrointestinal tract. One patient had multiple lesions situated in the stomach, 3 small intes-From Mary Immaculate Hospital Div., Catholic Med-*

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Primary gastric lymphomas: A clinicopathologic study of 58 cases with long-term follow-up and literature review

Brooks

Enterline

1983

Cancer

204

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A large series of primary gastric lymphomas with long‐term follow‐up (average, 12.8 years) is reported. A number of factors known to affect nodal lymphoma were examined. Five‐and ten‐year survival rates were 57 and 46%, respectively. Statistically significant favorable prognostic variables were smaller tumor size (≤7 cm), superficial mural invasion (submucosal only), and pathologic Stage I disease; these variables were intimately interrelated. A favorable influence on survival was discerned concerning histologic type and nodular histology, although still below statistical significance. No significant relation to survival was observed concerning clinical weight loss or palpable mass, vascular invasion, mode of therapy, or histologic subtypes of “histocytic” lymphoma. Of patients who succumbed to disease, 75% did so within two years (average, 1.8 years); however, later recurrence and death may occur. An argument for resection of localized disease is presented. Mitotic index and nuclear diameter were of diagnostic importance, and associated lesions such as pseudolymphomas are discussed in relation to pathogenesis. Histologic variation within tumors suggested visualization of clonal development in non‐Hodgkin's lymphomas.

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Lymphoma of the Stomach

Cited by 24 publications

References 6 publications

Gastric Lymphosarcoma Limited to the Mucosa and Submucosa Simulating the Macroscopical Appearance of Early Cancer Type II c

Gastric Lymphosarcoma Limited to the Mucosa and Submucosa Simulating the Macroscopical Appearance of Early Cancer Type II c

Extramedullary plasmacytoma of stomach

Primary gastric lymphomas: A clinicopathologic study of 58 cases with long-term follow-up and literature review

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