Lymphoproliferative Disorders in Multiple Primary Cancers

Demırcı, Umut; Özdemir, Nuriye; Benekli, Mustafa; Babacan, Nalân Akgül; Çetin, Bülent; Baykara, Meltem; Coşkun, Uğur; Zengi̇n, Nurullah; Büyükberber, Süleyman

doi:10.7314/apjcp.2012.13.1.383

Cited by 6 publications

(7 citation statements)

References 22 publications

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“…Owing to the relatively low NPV of EBUS-TBNA, tumor-negative findings should be verified by surgical or other techniques (Cetinkaya et al, 2013). The residual risk of lung cancer has been reported after lymphoma treatment (Demirci et al, 2012). Lung malignancies developing after the treatment of lymphoma generally have a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in the Diagnosis of Lymphoma

Şentürk¹,

Babaoğlu²,

Kılıç³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is highly accurate in diagnosing mediastinal lymphadenopathies of lung cancer and benign disorders. However, the utility of EBUS-TBNA in the diagnosis of mediastinal lymphomas is unclear. The aim of this study was to determine the diagnostic value of EBUS-TBNA in patients with suspected lymphoma. Materials and Methods: Sixty-eight patients with isolated mediastinal lymphadenopathy and suspected of lymphoma were included in the study. EBUS-TBNA was performed on outpatients under moderate sedation. The sensitivity, specificity, negative predictive value and diagnostic accuracy of EBUS-TBNA were calculated. Results: Sixty-four patients were diagnosed by EBUS-TBNA, but four patients with non-diagnostic EBUS-TBNA required surgical procedures. Thirty-five (51.5%) patients had sarcoidosis, six (8.8%) had reactive lymphadenopathy, nine (13.3%) had tuberculosis, one (1.5%) had squamous cell carcinoma, two (2.9%) had sarcoma and fifteen (22%) had lymphoma (follicular center cell, large B-cell primary, and Hodgkin lymphomas in three, two, and ten, respectively). Of the 15 lymphoma patients, thirteen were diagnosed by EBUS and two by thoracotomy and mediastinoscopy. The sensitivity, specificity, negative predictive value, and diagnostic accuracy of EBUS-TBNA for the diagnosis of lymphoma were calculated as 86.7%, 100%, 96.4%, and 97%, respectively. Conclusions: EBUS-TBNA can be employed in the diagnosis of mediastinal lymphoma, instead of more invasive surgical procedures.

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Section: Discussionmentioning

confidence: 99%

Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in the Diagnosis of Lymphoma

Şentürk¹,

Babaoğlu²,

Kılıç³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Among NHL subtypes, DLBCL patients have been further studied for epidemiologic characteristics. Indeed, DLBCL has even been reported as the most frequent lympho-proliferative disorder detected in multiple primary cancers (Demirci et al, 2012). A Chinese study identified a direct or indirect protective effect of traditional Chinese medicine against DLBCL.…”

Section: Introductionmentioning

confidence: 99%

Type Distribution of Lymphomas in Lebanon: Five-Year Single Institution Experience

Sader-Ghorra

Rassy²,

Naderi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Lymphomas represent the fifth most frequent cancer in Lebanon. However, little is known concerning epidemiologic characteristics and distribution of lymphoid neoplasms according to the 2008 WHO classification. Materials and Methods: We conducted a retrospective study of lymphoma cases diagnosed from 2008 till 2012 at Hôtel-Dieu de France University Hospital. Results: A total of 502 new cases of lymphoma were diagnosed at our institution during a five year period: 119 cases (24%) were Hodgkin lymphomas (HL) and 383 cases (76%) were non-Hodgkin lymphomas (NHL). HLs were equally distributed in both sexes with a mean age at diagnosis of 30 years. Among NHL, 87% (332 cases) were B cell lymphomas, 9% (34 cases) were T cell lymphomas and 4%(17 cases) were classified as precursor lymphoid neoplasms. Among B cell lymphomas, 44% (147 cases) were diffuse large B cell lymphomas (DLBCL), 20% (65 cases) follicular lymphomas and 8% (27 cases) mantle cell lymphomas. DLBCL were equally distributed in both sexes with a mean age of 58 years. Follicular lymphomas were characterized by a male predominance (57%) and a mean age of 60 years. Mantle cell lymphomas showed a pronounced male predominance (85%) with a mean age of 60 years in men and 70 years in women. Some 72% of patients having T cell lymphomas were men, with a mean age of 57 years in men and 45 years in women, while 65% of patients having precursor lymphoid neoplasms were women with a mean age of 22 years in women and 30 years in men. Conclusions: The lymphoma subtype distribution in Lebanon is unique when compared to other countries from around the world. In fact, Hodgkin and follicular lymphomas are more frequent than in most Far Eastern, European and American countries, while T-cell lymphomas and DLBCL are less frequent.

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“…The study of multiple primary malignancies following LPD therefore has etiological and clinical importance. In a recent retrospective study on MPC by Demirci et al ( 30 ), the ability to diagnose a second cancer was shown to be earlier and more accurate than in past reports. In a population of 242 patients, the mean time for diagnosis of second malignancies was 55.5 months, whereas a third cancer was diagnosed after 22 months of the second neoplasm.…”

Section: Discussionmentioning

confidence: 87%

“…Diffuse large B-cell lymphoma as a subsequent cancer was the most frequent subtype of non-HL (NHL). Markedly high incidences of lung cancer, melanoma, soft tissue sarcoma, NHL, acute myeloid leukemia, genitourinary cancers, and head and neck cancer have been reported in lymphoma survivors ( 1 , 30 , 33 ). In the present case, the patient in case two had a synchronous diagnosis of LDP and lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Lung cancer and concurrent or sequential lymphoma: Two case reports with hypersensitivity to bevacizumab and a review of the literature

2014

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Non-small cell lung cancer (NSCLC) accounts for ~80% of all cases of lung cancer, and is the leading cause of cancer-related mortality worldwide. The majority of NSCLC cases of are diagnosed at an advanced stage. The outcome of patients with advanced NSCLC is poor with a median survival time of ~12 months in European and American populations. Lymphoproliferative disorders (LPDs) represent a heterogeneous group of expanding lymphoid cells, which occurs as a result of immune dysfunction. LPDs are often associated with primary solid cancers. We report two cases of LPD diagnosed concurrently and successively to NSCLC. The first case presents a 65-year-old female patient with advanced IV stage lung cancer, according to the International Association for the Study of Lung Cancer TNM staging system. The patient developed a concurrent lymphoma and was treated with first-line therapy including six cycles of gemcitabine and cisplatin, however, the patient experienced an adverse drug reaction to bevacizumab, which was administered after gemcitabine and prior to cisplatin. The second case presented a 74-year-old male patient diagnosed with large B cell lymphoma. The patient acheived remission of the illness, however, after one year the patient was diagnosed with squamous cell lung cancer. After three years, the patient underwent surgery, however disease recurrence was identified. Subsequently, the patient was treated with sterotactic radiotherapy and oral chemotherapy. A review of the associated literature was also conducted.

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Lymphoproliferative Disorders in Multiple Primary Cancers

Cited by 6 publications

References 22 publications

Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in the Diagnosis of Lymphoma

Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in the Diagnosis of Lymphoma

Type Distribution of Lymphomas in Lebanon: Five-Year Single Institution Experience

Lung cancer and concurrent or sequential lymphoma: Two case reports with hypersensitivity to bevacizumab and a review of the literature

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