Lymphotropic effect of dimephosphon, mexidol, and ketorolac is realized via activation of the lymphangion and stimulation of lymph formation

Abstract

Single parenteral administration of dimephosphon, mexidol, and ketorolac produces a lymphotropic effect. Dimephosphon directly affects the lymph system by increasing the number of functioning lymph capillaries and contractile activity of the walls and valves of small intestinal mesenteric lymphangions in rats, which leads to stimulation of lymph circulation. Mexidol and ketorolac increased only lymph flow rate in the thoracic lymph duct, which attested to their indirect effect of the lymph system (presumably associated with stimulation of lymph formation). Despite these differences in the mechanisms of lymphotropic effect, all these drugs activate lymph drainage and, hence, transporting function of the lymph system.

Morphofunctional Changes in Lymph Nodes During Intralymphatic Immunostimulation With Various Drugs in a Rat Model

“…The lymphatic system is a major component of the immune system and acts as a secondary circulatory system to drain excess fluid, proteins, and waste products from the extracellular space into the vascular system [1][2][3][4][5]. Lymphatic vessels have been used as potential drug delivery vehicles because certain lipophilic compounds, such as long-chain fatty acids, triglycerides, cholesterol esters, fat-soluble vitamins, and some xenobiotics, are transported through these channels [6][7][8][9][10][11].…”