Lysogeny1

Lwoff, A

doi:10.1128/mmbr.17.4.269-337.1953

Cited by 365 publications

(161 citation statements)

References 15 publications

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“…The term prophage was originally used (Lwoff, 1953) to denote the non-infectious form in which the phage is reproduced in lysogenic strains. It was subsequently found that some prophages, such as Ie and P2, are assorted during bacterial recombination exactly like genes of the host cell (Lederberg and Lederberg, 1953;Bertani and Six, 1958).…”

Section: Population Dynamics Of Phagementioning

confidence: 99%

“…Episomes in the integrated state behave as bacterial genes. It is an old idea that perhaps every bacterial gene has a certain potentiality to become a phage (Lwoff, 1953). If this were so, natural selection among temperate phages could almost be reduced to the selection of particular genes within the bacterial population.…”

Section: Population Dynamics Of Phagementioning

confidence: 99%

“…Each of their descendants can give rise to a clone of cells which are specifically immune to lysis by external infection with the type of phage which had previously entered their ancestor; and, in any such clone, a small constant proportion of cells lyses each generation and liberates into the medium new phage of the original type. Such strains are called lysogenic, and the noninfective, intracellular form in which the capacity to liberate a particular phage is reproduced is called prophage (Lwoff, 1953). IMPORTANT FACTS 1.…”

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confidence: 99%

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Conditions for the Existence of Bacteriophage

Campbell¹

1961

Evolution

121

116

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Section: Population Dynamics Of Phagementioning

confidence: 99%

Section: Population Dynamics Of Phagementioning

confidence: 99%

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confidence: 99%

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Conditions for the Existence of Bacteriophage

Campbell¹

1961

Evolution

121

116

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“…In contrast to lambda, P2 has been regarded as the prototype for the noninducible class of temperate phages (Bertani and Bertani, 1970;Liu and Haggard-Ljungquist, 1999). Spontaneous prophage induction (SPI) was first reported by André Lwoff in the 1950s, as cultures of Bacillus megaterium lysogens released free phages in the supernatant under noninducing conditions (Lwoff, 1953). SPI is often accompanied by the lysis of only a small population of bacterial cells (Nanda et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Symbiosis of a P2‐family phage and deep‐sea Shewanella putrefaciens

Liu

Tang

Zhang

et al. 2019

Environmental Microbiology

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Summary Almost all bacterial genomes harbour prophages, yet it remains unknown why prophages integrate into tRNA‐related genes. Approximately 1/3 of Shewanella isolates harbour a prophage at the tmRNA (ssrA) gene. Here, we discovered a P2‐family prophage integrated at the 3′‐end of ssrA in the deep‐sea bacterium S. putrefaciens. We found that ~0.1% of host cells are lysed to release P2 constitutively during host growth. P2 phage production is induced by a prophage‐encoded Rep protein and its excision is induced by the Cox protein. We also found that P2 genome excision leads to the disruption of wobble base pairing of SsrA due to site‐specific recombination, thus disrupting the trans‐translation function of SsrA. We further demonstrated that P2 excision greatly hinders growth in seawater medium and inhibits biofilm formation. Complementation with a functional SsrA in the P2‐excised strain completely restores the growth defects in seawater medium and partially restores biofilm formation. Additionally, we found that products of the P2 genes also increase biofilm formation. Taken together, this study illustrates a symbiotic relationship between P2 and its marine host, thus providing multiple benefits for both sides when a phage is integrated but suffers from reduced fitness when the prophage is excised.

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“…Some temperate phages such as coliphage P1 do not integrate into the host chromosome, but exist in a repressed replicable extra-chromosomal state. The host is now termed lysogenic [12], and is immune to superinfecting phages with genome sites homologous to the binding site of the repressor proteins being produced by the prophage. Reversion to the lytic cycle occurs at a certain frequency in growing lysogenic populations, although prophage induction is usually caused by cellular damage, especially that which affects the host DNA.…”

Section: Introductionmentioning

confidence: 99%

Phage-host interactions in soil

Marsh

Wellington

1994

FEMS Microbiology Ecology

101

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Phages are abundant and ubiquitous in nature, and are therefore important components of microbial communities. They can impact on host populations in several ways, including predation and alteration of host phenotype by genetic interactions. The dynamic survival of phage populations in soil requires infective interactions with host populations which must be undergoing growth. Hence survival is limited by the activity of soil bacteria, and phage populations must adopt strategies to overcome periods of inactivity. One of the most effective strategies is the lysogenic cycle of temperate phages. It is argued here that lysogeny in soil has a distinct advantage over virulence for phage and host survival, as opposed to aquatic ecosystems where virulence seems a more successful strategy for phage populations.

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Lysogeny1

Cited by 365 publications

References 15 publications

Conditions for the Existence of Bacteriophage

Conditions for the Existence of Bacteriophage

Symbiosis of a P2‐family phage and deep‐sea Shewanella putrefaciens

Phage-host interactions in soil

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