Macrocyclic Assembly: A Dive into the Pecking Order and Applied Aspects of Multitalented Metallomacrocycles

Abstract

To aid in knowledge of macrocyclic complexes and biomedical scientists, we are presenting here a review article with compilation of work done so far along in relation to macrocyclic ligands and their metal complexes. The metal ion chemistry of macrocyclic ligands has now become a major subdivision of coordination chemistry. This overview focuses on developments in design, synthesis, and self-assembly of metal-based architectures and ligands related to macrocyclic chemistry.

Potentially Biodynamic Tin(II) Complexes Derived from Macrocyclic Ligands: Synthesis, Spectral Analysis, In vitro Antibacterial, Antifungal and Brine Shrimp Lethality Evaluation

“…The biochemical action of organotin(II) complexes were influenced by coordination number of metal atom, geometry, oxidation states, thermodynamic and kinetic stability of complexes. It is well known that tin metal form stable bond with the carbon as well as with heteroatoms and also exits in different coordination number from four to eight 14,15 . The design of macrocyclic ligands and organotin complexes represents a relevant and qualified objective in the development of coordination chemistry.…”

The First Characterized Coordination Compounds of Macrocyclic Ligands Including Incorporated Tetrazole Rings

“…Macrocyclic compounds occupy a unique segment of chemical and biological sciences. Because of the size, complex structural organization, and limited conformational freedom, they are of interest as ligands for investigations of binding interactions with various targets, from small simple ions to huge molecules like peptides and DNA. − These investigations have achieved significant success in the area of drug discovery. , Nowadays, various macrocyclic drugs are involved in clinical practice. Complexation of macrocyclic ligands toward metal cations rather differs from linear analogues.…”