The yttrium phosphate dihydrate YPO4·2H2O was synthesized by thin-layer technique, and its crystal structure was obtained from X-ray powder diffraction data at room temperature. The structure of YPO4·2H2O was solved by direct methods and refined using the Rietveld analysis. The compound crystallizes in the monoclinic space group C2/c, with unit cell dimensions a = 6.15326(3), b = 14.99687(8), c = 5.57848(3) Å, β = 115.4319(4)º, V = 464.896(4) Å 3 , Z = 4. It has the gypsum-type crystal structure, with metal-phosphate 2D polymeric network, parallel to the ac plane. Water molecules, coordinated by the yttrium atoms, provide hydrogen bonding between the layers, resulting into a three-dimensional network. The crystal structure of YPO4·2H2O is compared with that of isotypic Y1-x(Gd,Dy,Er)xPO4·2H2O (x = 0.053), investigated earlier.

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Gold(i) complexes with phosphane and thiotetrazolate ligands were prepared and investigated as a new type of bioactive gold metallodrugs. The complexes triggered very efficient inhibition of the enzyme thioredoxin reductase (TrxR), which is an important molecular target for gold species. Strong cytotoxic effects were observed in MDA-MB-231 breast adenocarcinoma and HT-29 colon carcinoma cells, and the complexes also caused strong effects in vincristine resistant Nalm-6 leukemia cells. Cellular uptake studies showed elevated cellular gold levels for complexes containing a triphenylphosphane ligand, whereas trifurylphosphane analogues accumulated at significantly lower cellular concentrations.

Key indicatorsSingle-crystal X-ray study T = 293 K Mean '(C±C) = 0.005 A Ê R factor = 0.035 wR factor = 0.098 Data-to-parameter ratio = 26.4For details of how these key indicators were automatically derived from the article, see