Ion Channels 1988
DOI: 10.1007/978-1-4615-7302-9_3
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Macromolecular Sites for Specific Neurotoxins and Drugs on Chemosensitive Synapses and Electrical Excitation in Biological Membranes

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Cited by 20 publications
(4 citation statements)
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“…BK activates membrane receptors indirectly linked to ion channels through a second-messenger system, protein kinase C (18). Veratridine stimulates afferent endings by direct acti-vation of voltage-gated Na ϩ channels in the spike-initiating region of the afferent axon (2).…”
Section: Methodsmentioning
confidence: 99%
“…BK activates membrane receptors indirectly linked to ion channels through a second-messenger system, protein kinase C (18). Veratridine stimulates afferent endings by direct acti-vation of voltage-gated Na ϩ channels in the spike-initiating region of the afferent axon (2).…”
Section: Methodsmentioning
confidence: 99%
“…Ligand‐gated ion channels have a reasonable degree of sequence similarity; for example, they all seem to share a binding site for phencyclidine in the ion‐carrying pore. 40–43 Could this be the site of action of the I 1 ‐receptor ligands (Fig. 1B)?…”
Section: A Common Site Of Action?mentioning
confidence: 99%
“…Physostigmine is a well known blocker of acetyl cholinesterase, but also a channel blocker (Swanson and Albuquerque, 1987;Albuquerque et al, 1988). Results of pulse application of lo4 M acetylcholine alone and in combination with various concentrations of physostigmine to one patch are shown in Figure 2.…”
Section: Blocking Of Nicotinic Channels By Physostigminementioning
confidence: 99%