2021
DOI: 10.1183/13993003.02248-2020
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Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia

Abstract: RationalePremature infants exposed to oxygen are at risk for bronchopulmonary dysplasia (BPD), which is characterised by lung growth arrest. Inflammation is important, but the mechanisms remain elusive. Here, we investigated inflammatory pathways and therapeutic targets in severe clinical and experimental BPD.Methods and resultsFirst, transcriptomic analysis with in silico cellular deconvolution identified a lung-intrinsic M1-like-driven cytokine pattern in newborn mice after hyperoxia. These findings were con… Show more

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Cited by 60 publications
(45 citation statements)
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“…2020 ; Hirani et al. 2022 ). Mitochondria create most of the chemical energy needed to power the cell’s biochemical reactions.…”
Section: Discussionmentioning
confidence: 99%
“…2020 ; Hirani et al. 2022 ). Mitochondria create most of the chemical energy needed to power the cell’s biochemical reactions.…”
Section: Discussionmentioning
confidence: 99%
“…Immunofluorescent staining was performed as described previously [ 60 ]. Briefly, PFA-fixed liver sections (3 µm) were first deparaffinized in Neo-Clear ® (Sigma–Aldrich, St. Louis, MO, USA), rehydrated in a graded ethanol series (100%, 96%, 80% and 70% for one minute each) to PBS and then treated with MaxBlock™ reagent A autofluorescence reducing kit (MaxVision Biosciences, #MB-L, DC, Kenmore, WA, USA).…”
Section: Methodsmentioning
confidence: 99%
“…Hyperoxia-stimulated alveolar macrophages recruit neutrophils to the lungs via the activation of chemokine receptors [ 350 ] and produce and release factors that increase neutrophilic adherence [ 301 ]. In newborn infants, hyperoxia induces macrophage polarization to the M1 phenotype, favoring the presence of IL-6/STAT3 in the lungs [ 351 ]. Experimental models show that high levels of IL-6 (but also TNF-α and IL-1β) in the lungs are directly related to longer exposure to hyperoxia [ 293 , 331 , 333 , 352 ].…”
Section: Oxidative Stress and Inflammation In Hyperoxiamentioning
confidence: 99%