Macroporous Nanocomposite Materials Prepared by Solvent Evaporation from Pickering Emulsion Templates

Hu, Yang; Gu, Xiaoyu; Chen, Weike; Zou, Shengwen; Wang, Chaoyang

doi:10.1002/mame.201300449

Cited by 19 publications

(5 citation statements)

References 50 publications

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“…In this work, PLLA molecules with carboxyl end groups were used as the biodegradable and biocompatible modifiers to modify the HAp nanoparticles. PLLA molecules were grafted onto HAp surface by forming calcium carboxylate bonds between carboxyl end groups of PLLA and calcium ions on the HAp surfaces. − SEM and TEM studies of the dried g-HAp nanoparticles (Figure a and Supporting Information (SI) Figure S1) indicated that the g-HAp nanoparticles were irregular shape with broad diameter distribution. Dynamic light scattering study of dilute CH 2 Cl 2 dispersion of g-HAp nanoparticles (SI Figure S2a) showed that the mean diameter of g-HAp nanoparticles was about 580 nm.…”

Section: Resultsmentioning

confidence: 99%

Facile Fabrication of Poly(l-lactic Acid)-Grafted Hydroxyapatite/Poly(lactic-co-glycolic Acid) Scaffolds by Pickering High Internal Phase Emulsion Templates

Gu²,

Yang³

et al. 2014

ACS Appl. Mater. Interfaces

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118

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Porous scaffolds consisting of bioactive inorganic nanoparticles and biodegradable polymers have gained much interest in bone tissue engineering. We report here a facile approach to fabricating poly(l-lactic acid)-grafted hydroxyapatite (g-HAp)/poly(lactide-co-glycolide) (PLGA) nanocomposite (NC) porous scaffolds by solvent evaporation of Pickering high internal phase emulsion (HIPE) templates, where g-HAp nanoparticles act as particulate stabilizers. The resultant porous scaffolds exhibit an open and rough pore structure. The pore structure and mechanical properties of the scaffolds can be tuned readily by varying the g-HAp nanoparticle concentration and internal phase volume fraction of the emulsion templates. With increasing the g-HAp concentration or decreasing the internal phase volume fraction, the pore size and the porosity decrease, while the Young's modulus and the compressive stress enhance. Moreover, the in vitro mineralization tests show that the bioactivity of the scaffolds increases with increasing the g-HAp concentration. Furthermore, the anti-inflammatory drug ibuprofen (IBU) is loaded into the scaffolds, and the drug release studies indicate that the loaded-IBU exhibits a sustained release profile. Finally, in vitro cell culture assays prove that the scaffolds are biocompatible because of supporting adhesion, spreading, and proliferation of mouse bone mesenchymal stem cells. All the results indicate that the solvent evaporation based on Pickering HIPE templates is a promising alternative method to fabricate NC porous scaffolds for potential bone tissue engineering applications.

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Section: Resultsmentioning

confidence: 99%

Facile Fabrication of Poly(l-lactic Acid)-Grafted Hydroxyapatite/Poly(lactic-co-glycolic Acid) Scaffolds by Pickering High Internal Phase Emulsion Templates

Gu²,

Yang³

et al. 2014

ACS Appl. Mater. Interfaces

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118

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“…Dichloromethane (CH 2 Cl 2 ) was purchased from Guangzhou Chemical Factory (Guangzhou, China). The preparation of HAp nanoparticles and their surface hydrophobicity modification by PLLA containing carboxyl end groups (g-HAp) have been described in our previous work [37]. The particle diameters of g-HAp nanoparticles were in the range from 30 to 70 nm.…”

Section: Methodsmentioning

confidence: 99%

“…The HAp/PLLA NC scaffolds were fabricated by solvent evaporation from templating water-in-oil (W/O) Pickering emulsions according to the procedures reported in our previous study [37]. Firstly, the calculated amount of g-HAp nanoparticles was dispersed in a 4 w/v% CH 2 Cl 2 solution of PLLA (total, 5 mL) by ultrasonication at 0 • C for 10 min.…”

Section: Fabrication Of Hap/plla Nc Scaffoldsmentioning

confidence: 99%

“…And the NC macroporous materials showed a wide potential application for bone tissue-engineering scaffolds due to their highly porous structures, excellent mechanical property and surface hydrophilicity [37]. In this study, in order to investigate their possible applications for bone tissue-engineered scaffolds, the HAp/PLLA NC scaffolds were firstly fabricated by Pickering emulsion templating.…”

Section: Introductionmentioning

confidence: 99%

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Mineralization and drug release of hydroxyapatite/poly( l -lactic acid) nanocomposite scaffolds prepared by Pickering emulsion templating

Zou

Chen

et al. 2014

Colloids and Surfaces B: Biointerfaces

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“…E. coli was picked on the antibacterial effect, and also biocompatibility was verified by the cytotoxicity test of the epithelial cells. Furthermore, we prepared pH-sensitive NCs via Pickering encapsulation technology [29][30][31][32]. These NCs release their cargo above pH 5 when the humidity is high, conditions in which most bacteria, including Escherichia coli and fungi, are active.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Ligand Brush Nanocapsules for Robust Self-Controlled Antimicrobial Activity with Low Cytotoxicity at Target pH and Humidity

Koh

Lee

2022

Pharmaceutics

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This study prepared nanocapsules (NCs) with excellent self-controlled antimicrobial activity at pH 6–7 and humidity 45–100%, conditions in which most bacterial and fungal strains thrive. The nanocapsule substrate (NC@SiO2) was 676 nm in diameter, and the ligand-grafted capsule (NC@SiO2-g-MAA) was 888 nm. The large surface area and outer ligand brush of the NCs induced a rapid, self-controlled antibacterial response in the pH and humidity conditions needed for industrial and medical applications. Ligand-brush NCs containing an anionic antimicrobial drug had a rapid release effect because of the repellent electrostatic force and swelling properties of the ligand brushes. Controlled release of the drug was achieved at pH 6 and humidity of 45% and 100%. As many carboxylic acid groups are deprotonated into carboxylic acids at pH 5, the NC@SiO2-g-MAA had a high negative charge density. Carboxylic acid groups are anionized (–COO−) at pH 6 and above and push each other out of the capsule, expanding the outer shell as in a polymer brush to create the release behavior. The surface potential of the NC intermediate (NC@SiO2-MPS) was −23.45 [mV], and the potential of the capsule surface decreased to −36.4 [mV] when the MAA ligand brushes were grafted onto the surface of the capsule intermediate. In an antimicrobial experiment using Escherichia coli, a clear zone of 13–20 mm formed at pH 6, and the E. coli was eradicated completely at pH 6 and pH 7 when the humidity was 100%.

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Macroporous Nanocomposite Materials Prepared by Solvent Evaporation from Pickering Emulsion Templates

Cited by 19 publications

References 50 publications

Facile Fabrication of Poly(l-lactic Acid)-Grafted Hydroxyapatite/Poly(lactic-co-glycolic Acid) Scaffolds by Pickering High Internal Phase Emulsion Templates

Facile Fabrication of Poly(l-lactic Acid)-Grafted Hydroxyapatite/Poly(lactic-co-glycolic Acid) Scaffolds by Pickering High Internal Phase Emulsion Templates

Mineralization and drug release of hydroxyapatite/poly( l -lactic acid) nanocomposite scaffolds prepared by Pickering emulsion templating

Preparation of Ligand Brush Nanocapsules for Robust Self-Controlled Antimicrobial Activity with Low Cytotoxicity at Target pH and Humidity

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