Madecassoside suppresses LPS-induced TNF-α production in cardiomyocytes through inhibition of ERK, p38, and NF-κB activity

Cao, Wei; Li, Xiaoqiang; Zhang, Xiaonan; Ying, Hanjie; Zeng, Aiguo; Xie, Youhua; Wang, Siwang

doi:10.1016/j.intimp.2010.03.015

Cited by 45 publications

(36 citation statements)

References 29 publications

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“…Previous studies have elucidated some signal pathways leading to TNF- α in response to LPS. In particular, the activation of NF- κ B may play a significant role in LPS-induced expression of TNF- α [26, 27]. We deduced that compounds 1 , 2 , and 7 may inhibit LPS-induced TNF- α production through inhibition of NF- κ B signal pathway; similar conclusion has been reported in triterpenoids anti-inflammatory activity studies [28].…”

Section: Resultssupporting

confidence: 74%

Two New 3,4;9,10-seco-Cycloartane Type Triterpenoids fromIllicium difengpiand Their Anti-Inflammatory Activities

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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A pair of new 3,4;9,10-seco-cycloartane type triterpenoid stereoisomerides: 24R,25-dihydroxy-3,4;9,10-seco-4(28)-cycloarten-10,3-olide (1) named Illiciumolide A and 24S,25-dihydroxy-3,4;9,10-seco-4(28)-cycloarten-10,3-olide (2) named Illiciumolide B were isolated from the stem bark of Illicium difengpi, as well as five known biogenetically related triterpenoids, including sootepin E (3), betulinic acid (4), lupeol (5), (all-Z)-1,5,9,13,17,21-hexamethyl-1,5,9,13,17,21-cyclotertracosahexaene (6), and (all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (7). The structures of two new compounds were determined on the basis of spectroscopic analysis including 1D-, 2D-NMR, and MS techniques. Two assays were conducted: inhibition of tumor necrosis factor-alpha (TNF-α) and inhibition of nuclear factor kappa B (NF-κB) in RAW264. 7 cells induced by lipopolysaccharide (LPS). It was observed that compounds 1, 2 and 7 showed significant inhibition of TNF-α production and NF-κB release. The molecule docking results showed that compounds 1 and 2 got high fitness scores with dual specificity mitogen-activated protein kinase kinase 1 (MPKK1), whose activation plays a pivotal role between TNF-α and activation of NF-κB. The anti-HIV-1 potency of compounds 1–5 was also discussed, in addition to the results of computer-aided screening for targets.

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Section: Resultssupporting

confidence: 74%

Two New 3,4;9,10-seco-Cycloartane Type Triterpenoids fromIllicium difengpiand Their Anti-Inflammatory Activities

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Neonatal rat cardiomyocytes were isolated from the ventricles of one to three-day-old Sprague-Dawley rats, according to the previously described procedures [25]. Cells enriched for cardiomyocytes were plated on 96-well plates and maintained in DMEM containing 10% FBS, 100 U/ml penicillin, and 100 μg/ml streptomycin.…”

Section: Cardiomyocyte Culture and Cytotoxicity Assaymentioning

confidence: 99%

The comparison of α-bromo-4-chlorocinnamaldehyde and cinnamaldehyde on coxsackie virus B3-induced myocarditis and their mechanisms

Ya¹,

Cao²,

Xie³

et al. 2012

International Immunopharmacology

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“…FY1352B1209 (C48H78O20). Previous studies have reported that MA exhibits antioxidant and anti-inflammatory activities [9] and is able to suppress the activation of the NF-κB signaling pathway [10][11][12]. However, the inhibitory effects of MA on articular cartilage degradation have not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside

Moqbel

et al. 2020

Oxidative Medicine and Cellular Longevity

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As a joint disease, osteoarthritis (OA) is caused by the breakdown of subchondral bone and cartilage damage. Inflammatory factors, such as interleukin-(IL-) 1β, mediate the progression of OA. Madecassoside (MA), a triterpenoid component derived from the gotu kola herb (Centella asiatica), exhibits various pharmacological effects, including antioxidative and anti-inflammatory properties. In the present study, the protective effects and possible mechanism of MA on the treatment of OA were investigated. MA was demonstrated to significantly suppress the IL-1β-induced overexpression of matrix metalloproteinase-(MMP-) 3, MMP-13, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) and to decrease the IL-1β-induced degradation of type II collagen and sox9. Additionally, MA was able to reduce the IL-1β-induced phosphorylation of p65 in osteoarthritic chondrocytes. Furthermore, in a rat OA model, MA prevented cartilage degeneration and reduced the OARSI score in the MAtreated group compared with the OA group. The present study showed that MA suppresses the nuclear factor-κB signaling pathway, reducing IL-1β-induced chondrocyte inflammation, which indicates the therapeutic potential of MA in patients with OA.

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Madecassoside suppresses LPS-induced TNF-α production in cardiomyocytes through inhibition of ERK, p38, and NF-κB activity

Cited by 45 publications

References 29 publications

Two New 3,4;9,10-seco-Cycloartane Type Triterpenoids fromIllicium difengpiand Their Anti-Inflammatory Activities

Two New 3,4;9,10-seco-Cycloartane Type Triterpenoids fromIllicium difengpiand Their Anti-Inflammatory Activities

The comparison of α-bromo-4-chlorocinnamaldehyde and cinnamaldehyde on coxsackie virus B3-induced myocarditis and their mechanisms

Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside

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