Madhuca indica Inhibits Breast Cancer Cell Proliferation by Modulating COX-2 Expression

The Trinity of Matrix Metalloproteinases, Inflammation, and Cancer: A Literature Review of Recent Updates

“…Arachidonic acid derivatives are known to participate in inflammation, pain, and fever and they are found to be closely linked with tumour development as well. Among those, COX-1 is present on a stable level in nearly all tissues whereas COX-2 is observed highly expressed in hyperplastic tissues such as breast cancer, lung cancer, and gastric cancer [ 110 - 112 ]. In a study conducted on oral squamous cell carcinoma (OSCC), the expression level of COX-2 and MMP-7 were investigated.…”

Madhuca indica: A Review on the Phytochemical and Pharmacological Aspects

“… Anticancer activity Bark and Leaves: Ethanolic extract [ 46 ] 14. Cytotoxic activity Flowers: Methanolic extract [ 47 ] 15. Anthelminthic activity Bark and Leaves: Methanolic extract [ 38 ] 16.…”

“…They observed that the activity involves the inducing of apoptosis through up regulating the expression of Caspase assay 3/7 (P < 0.0001), through a decrease in the expression of COX-2 mRNA and COX-2 protein in both MCF-7 and MDA-MB-468 cells, in a dose dependent manner. The synergistic effect of extract with a chemotherapeutic drug paclitaxel, found to be more effective as compared to either extract or paclitaxel alone [ 47 ]. Antinociceptive and antidiarrheal activity of the bark extract was studied on mice [ 48 ] by using acetic acid induced writhing resulting algesia by liberation of endogenous substances which excite the pain nerve endings, and castor oil induced diarrhea, respectively.…”