Maghemite-nanoMIL-100(Fe) Bimodal Nanovector as a Platform for Image-Guided Therapy

Sene, Saad; Marcos-Almaraz, María T.; Menguy, Nicolas; Scola, Joseph; Volatron, Jeanne; Rouland, Richard; Grenèche, Jean-Marc; Miraux, Sylvain; Menet, Clotilde; Guillou, Nathalie; Gazeau, Florence; Serre, Christian; Horcajada, Patricia; Steunou, Nathalie

doi:10.1016/j.chempr.2017.06.007

Cited by 80 publications

(80 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since Ferey and co-workers reported the first study of iron-based MOFs for applications in biomedicine [31], a tremendous amount of work has emerged towards developing the great potential for various applications of nanoparticulate MOFs (NMOFs) in healthcare [16,[32][33][34][35][36] Iron MOFs are probably the most widely studied materials for healthcare applications to date, because iron is well tolerated, with a 50% lethal dose (LD 50 ) of 30 gkg -1 when orally administered to rats, while their high porosity enables very high drug loadings [31,[37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Application of zirconium MOFs in drug delivery and biomedicine

Lázaro

Forgan

2019

Coordination Chemistry Reviews

552

176

View full text Add to dashboard Cite

Nanoparticulate metal-organic frameworks (MOFs) have the requisite high storage capacities, tailorable structures, ease of functionalisation, and excellent biocompatibilities for application as nanoscale drug delivery devices (DDSs). Zirconium MOFs in particular combine optimal stability towards hydrolysis and postsynthetic modification with low toxicity, and so are particularly suited for biological applications. This review covers the use of Zr MOFs as DDSs with focus on the different physical properties that makes them attractive for use. The various methods for modifying the surfaces of Zr MOFs are described with pertinent examples of the resulting enhancements in aqueous stability, colloidal dispersion, and stimuli-responsive drug release. The in vitro and in vivo application of Zr MOFs for photodynamic therapy and drug delivery are discussed with respect to the structural features of the MOFs and their surface functionality, and perspectives on their future applications and analogous hafnium MOFs are given.

show abstract

Section: Introductionmentioning

confidence: 99%

Application of zirconium MOFs in drug delivery and biomedicine

Lázaro

Forgan

2019

Coordination Chemistry Reviews

552

176

View full text Add to dashboard Cite

show abstract

“…Noteworthily, during the past 3–4 years, an increasing number of studies have highlighted the first in vivo benefits of nanoMOFs to treat different diseases in animal models. One can thus expect in the upcoming years exciting new developments concerning the preclinical in vivo evaluation of MOFs . A key condition of success will nevertheless require furthering strengthening the exchanges between chemists, pharmacists, and clinicians, for the creation of multidisciplinary projects dealing with the translation of nanoMOFs into more realistic biomedical solutions.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the presence of maghemite NPs conferred to the nanoMOFs a very high r 2 relaxivity, comparable to the best commercial available systems and these imaging properties were further confirmed in vivo by T 2 ‐weighted MRI. This potential theranostic tool improved imaging contrast properties of the nanoMOFs in vivo while conserving the high drug loading/release capacities . Another theranostic approach based on ZIF‐8 NPs was recently reported by Yang et al in a sophisticated system to combine MRI, multidrug chemotherapy, and photothermal synergistic therapy ( Figure ) .…”

Section: Recent Advances In Theranosticsmentioning

confidence: 94%

See 1 more Smart Citation

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

et al. 2018

Self Cite

View full text Add to dashboard Cite

In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic frameworks (nanoMOFs) at the preclinical level for biomedical applications. Many of them were reported very recently based on their bioactive composition, anticancer application, or from a general drug delivery/theranostic perspective. In this review, the authors aim at providing a global view of the studies that evaluated MOFs' biomedical applications at the preclinical stage, when in vivo tests are described either for pharmacological applications or for toxicity evaluation. The authors first describe the current surface engineering approaches that are crucial to understand the in vivo behavior of the nanoMOFs. Finally, after a detailed and comprehensive analysis of the in vivo studies reported with MOFs so far, and considering the general evolution of the drug delivery science, the authors suggest new directions for future research in the use of nanoMOFs for biomedical applications.

show abstract

“…Combining probiotic bacteria's capacity to nest in different tissues of the gastrointestinal tract and the interesting optical and magnetic properties of AuNPs and MNPs, we intend to produce new functional foods for biomedical applications [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Magnetic and Golden Yogurts. Food as a Potential Nanomedicine Carrier

et al. 2020

View full text Add to dashboard Cite

Yogurt is one of the most emblematic and popular fermented foods. It is produced by the fermentation of milk lactose by bacteria such as Streptococcus thermophilus and Lactobacillus acidophilus. Magnetic (MNPs) and gold nanoparticles (AuNPs) were incorporated into the exopolysaccharides (EPSs) of these bacteria. The functionalized bacteria were characterized by UV-vis spectroscopy and transmission electron microscopy. A large number of MNPs and AuNPs were bound to the bacterial EPS. Interestingly, the nanoparticles’ (NPs) presence did not affect the bacteria’s capacity to ferment milk and to produce magnetic and golden yogurts. Magnetic and golden yogurts represent the perfect combination of emblematic food and nanoparticles and have a range of potential biomedical applications: use in iron-deficiency anemia, diagnosis and hyperthermia treatment of appropriate digestive diseases, and interest in glamour cuisine.

show abstract

Maghemite-nanoMIL-100(Fe) Bimodal Nanovector as a Platform for Image-Guided Therapy

Cited by 80 publications

References 85 publications

Application of zirconium MOFs in drug delivery and biomedicine

Application of zirconium MOFs in drug delivery and biomedicine

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

Magnetic and Golden Yogurts. Food as a Potential Nanomedicine Carrier

Contact Info

Product

Resources

About