Magnesium-based biomaterials as emerging agents for bone repair and regeneration: from mechanism to application

Zhou, Hang; Liang, Bing; Jiang, Haitao; Deng, Zhong‐Liang; Yu, Kexiao

doi:10.1016/j.jma.2021.03.004

Cited by 231 publications

(120 citation statements)

References 221 publications

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“…Mg doping enhances integrin-ligand binding and appears to protect the cells by oxidative stress [ 13 ]. MgHA facilitates new bone formation and apposition on bone implants, controlling the initial dissolution rate and addressing bone regeneration [ 14 ]. It was previously demonstrated that MgHA has significant antibacterial and larvicidal ability against various pathogens [ 15 ], particularly bacteria such as Staphylococcus aureus , Pseudomonas aeruginosa , and Escherichia coli [ 16 ].…”

Section: Bioactive Ion-doped Nanohydroxyapatitesmentioning

confidence: 99%

Nature-Inspired Unconventional Approaches to Develop 3D Bioceramic Scaffolds with Enhanced Regenerative Ability

et al. 2021

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Material science is a relevant discipline in support of regenerative medicine. Indeed, tissue regeneration requires the use of scaffolds able to guide and sustain the natural cell metabolism towards tissue regrowth. This need is particularly important in musculoskeletal regeneration, such as in the case of diseased bone or osteocartilaginous regions for which calcium phosphate-based scaffolds are considered as the golden solution. However, various technological barriers related to conventional ceramic processing have thus far hampered the achievement of biomimetic and bioactive scaffolds as effective solutions for still unmet clinical needs in orthopaedics. Driven by such highly impacting socioeconomic needs, new nature-inspired approaches promise to make a technological leap forward in the development of advanced biomaterials. The present review illustrates ion-doped apatites as biomimetic materials whose bioactivity resides in their unstable chemical composition and nanocrystallinity, both of which are, however, destroyed by the classical sintering treatment. In the following, recent nature-inspired methods preventing the use of high-temperature treatments, based on (i) chemically hardening bioceramics, (ii) biomineralisation process, and (iii) biomorphic transformations, are illustrated. These methods can generate products with advanced biofunctional properties, particularly biomorphic transformations represent an emerging approach that could pave the way to a technological leap forward in medicine and also in various other application fields.

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Section: Bioactive Ion-doped Nanohydroxyapatitesmentioning

confidence: 99%

Nature-Inspired Unconventional Approaches to Develop 3D Bioceramic Scaffolds with Enhanced Regenerative Ability

et al. 2021

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“…Furthermore, the degradation rate of biodegradable and biocompatible polymers is slowly through water absorption and hydrolysis, introducing bio-products incorporated into other metabolic pathways or removed from the body [25]. The controlled delivery of drugs in Mg-based materials with surface coatings, especially a variety of polymer coatings, also has been confirmed [26]. Additionally, polymeric materials have exceptional multifunctional properties that can be used in upcoming magnesium bio-implants (Figure 1).…”

Section: Introductionmentioning

confidence: 98%

“…The influence of different polymers on Mg and its alloys' biodegradation performance and biocompatibility is comprehensively discussed [30]. Furthermore, we summarize the current understanding of the possible corrosion mechanisms of polymer-coated and polymer-based composite-coated Mg and its alloys based on the previous studies [26]. Finally, the major challenges and difficulties are summarized, with a focus on the promising research on polymer-coated Mg-based implant materials.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

et al. 2021

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The development of biodegradable implants is certainly intriguing, and magnesium and its alloys are considered significant among the various biodegradable materials. Nevertheless, the fast degradation, the generation of a significant amount of hydrogen gas, and the escalation in the pH value of the body solution are significant barriers to their use as an implant material. The appropriate approach is able to solve this issue, resulting in a decrease the rate of Mg degradation, which can be accomplished by alloying, surface adjustment, and mechanical treatment. Surface modification is a practical option because it not only improves corrosion resistance but also prepares a treated surface to improve bone regeneration and cell attachment. Metal coatings, ceramic coatings, and permanent polymers were shown to minimize degradation rates, but inflammation and foreign body responses were also suggested. In contrast to permanent materials, the bioabsorbable polymers normally show the desired biocompatibility. In order to improve the performance of drugs, they are generally encapsulated in biodegradable polymers. This study summarized the most recent advancements in manufacturing polymeric coatings on Mg alloys. The related corrosion resistance enhancement strategies and future potentials are discussed. Ultimately, the major challenges and difficulties are presented with aim of the development of polymer-coated Mg-based implant materials.

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“…Magnesium alloys have been investigated in recent years in terms of benefits for their usage as biodegradable metal implants [1][2][3][4][5]. The biomedical magnesium alloys reach better biodegradable and absorption properties in the environment of the human body when compared to the conventional metallic implant materials such as titanium alloys, stainless steels, and cobalt alloys [2,5]. However, a major obstacle to the use of magnesium alloys as medical implants is their low corrosion resistance in vivo [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…For its potential in biomedical applications is the group of magnesium alloys alloyed by aluminum and zinc widely studied for several years [1][2][3][4][5]. Zinc in combination with aluminum eliminates the negative influence of impurities such as iron and nickel on the alloy corrosion resistance and also improves alloys mechanical properties [10].…”

Section: Introductionmentioning

confidence: 99%

Characterization and Corrosion Properties of Fluoride Conversion Coating Prepared on AZ31 Magnesium Alloy

et al. 2021

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Wrought AZ31 magnesium alloy was used as the experimental material for fluoride conversion coating preparation in Na[BF4] molten salt. Two coating temperatures, 430 °C and 450 °C, and three coating times, 0.5, 2, and 8 h, were used for the coating preparation. A scanning electron microscope and energy-dispersive X-ray spectroscopy were used for an investigation of the surface morphology and the cross-sections of the prepared coatings including chemical composition determination. The corrosion resistance of the prepared specimens was investigated in terms of the potentiodynamic tests, electrochemical impedance spectroscopy and immersion tests in the environment of simulated body fluids at 37 ± 2 °C. The increase in the coating temperature and coating time resulted in higher coatings thicknesses and better corrosion resistance. Higher coating temperature was accompanied by smaller defects uniformly distributed on the coating surface. The defects were most probably created due to the reaction of the AlxMny intermetallic phase with Na[BF4] molten salt and/or with the product of its decomposition, BF3 compound, resulting in the creation of soluble Na3[AlF6] and AlF3 compounds, which were removed from the coating during the removal of the secondary Na[MgF3] layer. The negative influence of the AlxMny intermetallic phase was correlated to the particle size and thus the size of created defects.

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Magnesium-based biomaterials as emerging agents for bone repair and regeneration: from mechanism to application

Cited by 231 publications

References 221 publications

Nature-Inspired Unconventional Approaches to Develop 3D Bioceramic Scaffolds with Enhanced Regenerative Ability

Nature-Inspired Unconventional Approaches to Develop 3D Bioceramic Scaffolds with Enhanced Regenerative Ability

A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

Characterization and Corrosion Properties of Fluoride Conversion Coating Prepared on AZ31 Magnesium Alloy

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