Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance

Barbagallo, Mario; Lj, Dominguez

doi:10.1016/j.abb.2006.05.007

Cited by 313 publications

(317 citation statements)

References 93 publications

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“…Several components in coffee and tea have been suggested as possible causal factors. Magnesium plays a role in regulating insulin action and is inversely associated with insulin sensitivity and type 2 diabetes [7]. Potassium intake has also been associated with a reduced risk of diabetes [8].…”

Section: Introductionmentioning

confidence: 99%

Coffee and tea consumption and risk of type 2 diabetes

et al. 2009

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Aims/hypothesis The aim of this study was to examine the association of consumption of coffee and tea, separately and in total, with risk of type 2 diabetes and which factors mediate these relations. Methods This research was conducted as part of the Dutch Contribution to the European Prospective Investigation into Cancer and Nutrition, which involves a prospective cohort of 40,011 participants with a mean follow-up of 10 years. A validated food-frequency questionnaire was used to assess coffee and tea consumption and other lifestyle and dietary factors. The main outcome was verified incidence of type 2 diabetes. Blood pressure, caffeine, magnesium and potassium were examined as possible mediating factors. Results During follow-up, 918 incident cases of type 2 diabetes were documented. After adjustment for potential confounders, coffee and tea consumption were both inversely associated with type 2 diabetes, with hazard ratios of 0.77 (95% CI 0.63-0.95) for 4.1-6.0 cups of coffee per day (p for trend=0.033) and 0.63 (95% CI: 0.47-0.86) for >5.0 cups of tea per day (p for trend=0.002). Total daily consumption of at least three cups of coffee and/or tea reduced the risk of type 2 diabetes by approximately 42%. Adjusting for blood pressure, magnesium, potassium and caffeine did not attenuate the associations. Conclusions/interpretation Drinking coffee or tea is associated with a lowered risk of type 2 diabetes, which cannot be explained by magnesium, potassium, caffeine or blood pressure effects. Total consumption of at least three cups of coffee or tea per day may lower the risk of type 2 diabetes.

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Section: Introductionmentioning

confidence: 99%

Coffee and tea consumption and risk of type 2 diabetes

et al. 2009

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“…Mustering and handling of cattle for collection of blood or urine samples may precipitate grass tetany in susceptible cows, and may be impractical when many cows in the mob have young calves at foot. In human medicine, subclinical hypomagnesaemia is associated with diabetes, metabolic syndrome and cardiovascular disease [82,83], and may also have a negative impact on the ability to cope with hypocalcaemia, since adequate magnesium level is important for both the excretion of parathyroid hormone [84] and the tissue responsiveness to parathyroid hormone [85].…”

Section: Diagnosing Grass Tetanymentioning

confidence: 99%

Hypomagnesemia Tetany in Cattle

Zelal¹

2017

J Adv Dairy Res

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Grass tetany, sometimes called grass staggers or hypomagnesemia, can be a serious problem in Syria with cattle grazing small grain or ryegrass pastures. hypomagnesemia tetany has been known under a variety of names, including magnesium tetany, lactation tetany and grass staggers, but most of these terms have been discarded because the disease is not always associated with lactation or with grazing animals.The exact cause of hypomagnesemia tetany in ruminant animals is a dietary deficiency of magnesium that may be a contributory factor. Some research workers consider the condition to be caused by a cation-anion imbalance in the diet, and Some research workers believe that high intake of the element (K & Na) may interfere with the absorption and metabolism of magnesium in the animal, which may be an important factor in the etiology of hypomagnesemia tetany.Although the exact cause of hypomagnesemia is still uncertain, the primary factor would appear to be inadequate absorption of magnesium from the digestive tract. A high degree of success in preventing hypomagnesemia may be obtained by increasing the magnesium intake. This can be effected by feeding with magnesium rich mineral mixtures or, alternatively, by increasing the magnesium content of pasture by the application of magnesium fertilizers.

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“…Inverse correlations between magnesium and fasting plasma glucose, HbA1C, HOMA-IR have been observed. 11,12 Factors implicated in hypomagnesemia in diabetics include diets low in magnesium 13 ,osmotic diuresis causing high renal excretion of magnesium, insensitivity to insulin affecting intracellular magnesium transport and thereby causing increased loss of the extracellular magnesium 14 rampant use of loop and thiazides diuretics promoting magnesium wasting, 15,16 diabetic autonomic neuropathies 4 and reduced tubular reabsorption due to insulin resistance 17 . Sometimes the more common use of antibiotics and antifungals such as aminoglycosides and amphotericin in patients with diabetes may also contribute to renal magnesium wasting 18 .…”

Section: Discussionmentioning

confidence: 99%