Magnesium status and the metabolic syndrome: A systematic review and meta-analysis

Sarrafzadegan, Nizal; Khosravi-Boroujeni, Hossein; Lotfizadeh, Masoud; Pourmogaddas, Ali; Salehi‐Abargouei, Amin

doi:10.1016/j.nut.2015.09.014

Cited by 82 publications

(72 citation statements)

References 67 publications

(115 reference statements)

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“…(101) Magnesium can also raise serum HDL-C while reducing LDL-C and TA, through increasing lipoprotein lipase activity among others. (101) Magnesium’s potential effect on weight maintenance was also reported, forming an un-absorbable soap with fatty acids and cholesterol, decreasing their absorption, and thus reducing energy intake from the diet.…”

Section: Discussionmentioning

confidence: 99%

Dairy product consumption and its association with metabolic disturbance in a prospective study of urban adults

et al. 2018

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The role of dairy foods and related nutrients in cardio-metabolic health etiology is poorly understood. We investigated longitudinal associations between the metabolic syndrome (MetS) and its components with key dairy exposures. We used prospective data from a bi-racial cohort of urban adults [30–64y at baseline (N=1,371)], the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS), in Baltimore City, MD (2004–2013). The average of 2 24-hour dietary recalls measured 4–10d apart was computed at baseline (V1) and follow-up (V2) waves. Annual rates of change (Δ) in dairy foods and key nutrients were estimated. Incident obesity, central obesity and metabolic syndrome (MetS) were determined. Among key findings, in the overall urban adult population, both cheese and yogurt (V1 and Δ) were associated with an increased risk of central obesity [HR=1.13, 95% CI:1.05,1.23 per oz equivalent of cheese (V1); HR=1.21, 95%CI: 1.01, 1.44, per fl oz equivalent of yogurt (V1)]. Baseline fluid milk intake (V1 in cup equivalents) was inversely related to MetS [HR=0.86, 95%CI: 0.78,0.94], specifically to dyslipidemia-triacylglycerol (TA) [HR=0.89, 95% CI:0.81,0.99], though it was directly associated with dyslipidemia-High Density Lipoprotein-Cholesterol (HDL-C), [HR=1.10, 95% CI:1.01,1.21]. Furthermore, Δcalcium and Δphosphorus were inversely related to dyslipidemia-HDL and MetS incidence, respectively, while Δdairy fat was positively associated with incident TA- and HDL-C-dyslipidemias and MetS. A few of those associations were sex- and race-specific. In sum, various dairy exposures had differential associations with metabolic disturbances. Future intervention studies should uncover how over-time changes in dairy components may affect metabolic disorders.

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Section: Discussionmentioning

confidence: 99%

Dairy product consumption and its association with metabolic disturbance in a prospective study of urban adults

et al. 2018

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“…Conditions such as Type 2 Diabetes [10][11][12], Alzheimer's [13,14] and cardiovascular disease [15,16] have been linked with magnesium deficiency, however the mechanisms of Mg 2+ regulation in such disease states are poorly understood [17,18]. Fluorescent chemosensors, in combination with specialised imaging technologies, provide a useful tool to study the role of metal ions in cellular processes as they enable detection in and around cells with spatial and temporal resolution [19].…”

Section: Introductionmentioning

confidence: 99%

A Rationally Designed, Spiropyran-Based Chemosensor for Magnesium

et al. 2018

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Magnesium ions (Mg 2+ ) play an important role in mammalian cell function; however, relatively little is known about the mechanisms of Mg 2+ regulation in disease states. An advance in this field would come from the development of selective, reversible fluorescent chemosensors, capable of repeated measurements. To this end, the rational design and fluorescence-based photophysical characterisation of two spiropyran-based chemosensors for Mg 2+ are presented. The most promising analogue, chemosensor 1, exhibits 2-fold fluorescence enhancement factor and 3-fold higher binding affinity for Mg 2+ (K d 6.0 µM) over Ca 2+ (K d 18.7 µM). Incorporation of spiropyran-based sensors into optical fibre sensing platforms has been shown to yield significant signal-to-background changes with minimal sample volumes, a real advance in biological sensing that enables measurement on subcellular-scale samples. In order to demonstrate chemosensor compatibility within the light intense microenvironment of an optical fibre, photoswitching and photostability of 1 within a suspended core optical fibre (SCF) was subsequently explored, revealing reversible Mg 2+ binding with improved photostability compared to the non-photoswitchable Rhodamine B fluorophore. The spiropyran-based chemosensors reported here highlight untapped opportunities for a new class of photoswitchable Mg 2+ probe and present a first step in the development of a light-controlled, reversible dip-sensor for Mg 2+ .

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“…Several observational studies have demonstrated that low Mg intake is associated with a higher risk of several cardiovascular and metabolic diseases, including coronary artery disease (3) , hypertension (4) , metabolic syndrome (5) , and diabetes. (6) …”

Section: Introductionmentioning

confidence: 99%

Dietary magnesium intake and fracture risk: data from a large prospective study

et al. 2017

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Research considering the relationship between dietary magnesium (Mg) and osteoporosis and fractures are sparse and conflicting. We therefore aimed to investigate Mg intake and the onset of fractures in a large cohort of American men and women involved in the Osteoarthritis Initiative (OAI) over a follow-up period of 8 years. Dietary Mg intake (including those derived from supplementation) was evaluated through a food frequency questionnaire at baseline and categorized using gender-specific quintiles; osteoporotic fractures were evaluated through self-reported history. Overall, 3,765 participants (1,577 men; 2,071 women), mean age of 60.6±9.1 years were included. During follow-up, 560 individuals (198 men and 368 women) developed a new fracture. After adjusting for 14 potential confounders at baseline and taking those with lower Mg intake as reference (Q1), men (HR=0.47; 95%CI: 0.21–1.00, p=0.05) and women (HR=0.38; 95%CI: 0.17–0.82, p=0.01) in the highest quintile reported a significant lower risk of fracture. Women meeting the recommended Mg intake were at an 27% decreased risk of future fractures. In conclusion, higher dietary Mg intake has a protective effect on future osteoporotic fractures especially in women with high risk of knee osteoarthritis. Those women meeting the recommended Mg intake appear at lower risk of fractures.

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Magnesium status and the metabolic syndrome: A systematic review and meta-analysis

Cited by 82 publications

References 67 publications

Dairy product consumption and its association with metabolic disturbance in a prospective study of urban adults

Dairy product consumption and its association with metabolic disturbance in a prospective study of urban adults

A Rationally Designed, Spiropyran-Based Chemosensor for Magnesium

Dietary magnesium intake and fracture risk: data from a large prospective study

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