Magnesium-zinc scaffold loaded with tetracycline for tissue engineering application: In vitro cell biology and antibacterial activity assessment

Extrusion-based 3D printed magnesium scaffolds with multifunctional MgF2and MgF2–CaP coatings

“…The in vitro biodegradation rate of the Mg scaffolds (2.2 mm/y) was higher than the rates of the solid counterparts in the form of cast and rolled pure Mg (i.e., 0.84 and 1.94 mm/y, respectively) [28]. The volume loss of the scaffolds after 1 day of immersion (i.e., 37% ± 7%) was higher than that of pure Mg foam fabricated through powder metallurgy (around 25%) [70,71]. The higher biodegradation rate of the fabricated pure Mg scaffolds could be attributed to the high pore interconnectivity of the scaffolds, which led to the exposure of all Mg scaffold surfaces to the r-SBF solution, allowing corrosion to occur at multiple intricate sites.…”

“…The higher biodegradation rate of the fabricated pure Mg scaffolds could be attributed to the high pore interconnectivity of the scaffolds, which led to the exposure of all Mg scaffold surfaces to the r-SBF solution, allowing corrosion to occur at multiple intricate sites. In addition, the pressureless liquid-phase sintering strategy adopted in our study could only create vulnerable necks connecting Mg powder particles, instead of forming a flattened inter-particle area at a compaction step to impose plastic deformation in the route of conventional powder metallurgy [70,72]. Therefore, it is no surprise that the biodegradation rate of the fabricated Mg scaffolds was high.…”

Antibacterial agent-releasing scaffolds in dental tissue engineering

“…40 Several factors were assumed to account for the unspecific success, including but not restricted to using rather cytotoxic antibiotic pastes. 36 Several studies 3,[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] have reported the application and transmission prospects of 3D nano-fibers appropriate for antibiotic removal as a local technique for interior drug delivery that combined with injectable scaffolds, enriched or not with stem cells and growth factors (GFs), can increase the likelihood of the restoration of the human dental pulp. 36…”

Advances in Antibacterial Functionalized Coatings on Mg and Its Alloys for Medical Use—A Review

“…Metal elements such as silver, copper, Zn, and tin have been introduced to enhance the antibacterial properties of magnesium [21,58,65]. The bactericidal activity of these ions seems to depend on their gradual release from specimens into surrounding tissues.…”