Magnesiuric and calciuric effects of terbutaline in man

Bos, Willem Jan W.; Postma, Dirkje S.; Doormaal, van Jasper

doi:10.1042/cs0740595

Cited by 28 publications

(15 citation statements)

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“…[23] It is also attributed to either low magnesium intake in asthmatic or increased urinary loss of magnesium as a side-effect of therapy with ß 2 -agonist, corticosteroid, and theophylline. [122425] But hypomagnesemia is found to be present in the patients who are not on treatment with these drugs or even after withdrawal of the drugs. [151920] In our study we, however did not consider the dietary pattern of the patients but found hypomagnesemia to be more common with increased number of antiasthma medications like LABA, ICS, and THP.…”

Section: Discussionmentioning

confidence: 99%

Serum magnesium and stable asthma: Is there a link?

Das

Ghosh

et al. 2010

Lung India

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Background:Although magnesium is used through intravenous and inhalation route in the management of asthma, actual prevalence of hypomagnesemia in asthma is not known. We conducted this study: 1) to detect the prevalence of hypomagnesemia in stable asthma and 2) to assess the significance of hypomagnesemia in these patients.Design:Prospective clinical study.Setting:Department of Respiratory Medicine, Calcutta National Medical College, Kolkata.Period of Study:Four months from January, 2007, to April, 2007.Materials and Methods:Fifty patients attending outpatients department of respiratory medicine with stable asthma were randomly selected. They were assessed clinically and their serum magnesium levels were measured. This was compared with the serum magnesium values of 45 nonasthmatic healthy controls.Results:Out of 50 patients, 14 had hypomagnesemia. Possible relationship of hypomagnesemia with tachycardia, tachypnoea, severity of asthma, medication use, and previous and future exacerbations were analyzed.Conclusion:There was statistically significant association of hypomagnesemia with tachypnoea, severe asthma, use of long-acting β-agonist, inhaled corticosteroids, theophylline, use of ≥ 3 medications, previous and future exacerbations but not with tachycardia or use of short-acting β2 -agonist or montelukast.

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Section: Discussionmentioning

confidence: 99%

Serum magnesium and stable asthma: Is there a link?

Das

Ghosh

et al. 2010

Lung India

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“…Beta-adrenergic receptor agonists also appear to produce reductions in serum phosphate levels. In one study a single intravenous dose of terbutaline 12 mg produced a decrease in serum phosphate of 0.22 mmol.l À1 after 180 min [27]. There have been clinical reports of the development of hypophosphataemia during the treatment of acute asthma, although the clinical significance of these findings is unknown.…”

Section: Redistribution Of Phosphate Into Cellsmentioning

confidence: 99%

HypophosphataemiaPathophysiology, effects and management on the intensive care unit

1998

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SummaryRoutine detection and treatment of hypophosphataemia on the intensive care unit is commonplace. Hypophosphataemia has been associated with a multitude of clinical effects and there are many associations between correction of hypophosphataemia and improvement in symptoms. However, there is no evidence at present to support the routine correction of hypophosphataemia in the absence of clinical symptoms or signs.

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“…In previous studies, the cause of hypomagnesemia in patients with acute asthma was related to the use of β 2 -agonists either orally or intravenously, or by nebulization, rather than by inhalation [13][14][15]. In addition, oral or intravenous treatment can increase the costs [16,17].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Hypomagnesemia and Pulmonary Function Tests in Patients with Chronic Asthma

et al. 2018

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Objective: To investigate the relationship between serum values of magnesium and the parameters of the pulmonary function tests (PFT) in patients with chronic asthma. Subjects and Methods: This study recruited 50 patients with chronic stable asthma and 40 healthy individuals as a control group. Data on age, sex, severity of asthma, PFT, and details of drug therapy were obtained from each group. Serum magnesium, potassium, phosphorus, calcium, and sodium levels were also measured. To evaluate differences between groups, the Student t test or Mann-Whitney U test was performed for continuous variables, and the χ² test for categorical variables. Results: In the asthma group, 10% (n = 9) of the patients had hypomagnesemia and 5.5% (n = 5) had hypophosphatemia. Patients with asthma were divided into two groups: the hypomagnesemic group (n = 9) and the normomagnesemic group (n = 41). Forced expiratory volume in 1 s (FEV₁), FEV₁%, peak expiratory flow (PEF), and PEF% were lower in the hypomagnesemic group than in the normomagnesemic group (p = 0.02). Multiple logistic regression analysis revealed a statistically significant association between hypomagnesemia and PFT in the hypomagnesemic asthmatic group. The correlations of age with FEV₁, FEV₁%, PEF, and PEF% were as follows: p = 0.00, r = 0.29; p = 0.00, r = 0.43; p = 0.03, r = 0.22; p = 0.00, r = 0.38; and p = 0.03, r = 0.22, respectively. The correlation of serum magnesium levels with PFT (FEV₁, FEV₁%, PEF, PEF%) were as follows: p = 0.001, r = 0.29; p = 0.001, r = 0.43; p = 0.03, r = 0.22; and p = 0.001, r = 0.38, respectively. The other electrolytes were within the normal range in both groups. Conclusion: In this study, hypomagnesemia and hypophosphatemia were found to be the most common electrolyte abnormalities in patients with chronic stable asthma. FEV₁, FEV₁%, PEF, and PEF% were significantly lower in asthmatic patients with hypomagnesemia compared to asthmatic patients with normomagnesemia.

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Magnesiuric and calciuric effects of terbutaline in man

Cited by 28 publications

References 0 publications

Serum magnesium and stable asthma: Is there a link?

Serum magnesium and stable asthma: Is there a link?

HypophosphataemiaPathophysiology, effects and management on the intensive care unit

The Relationship between Hypomagnesemia and Pulmonary Function Tests in Patients with Chronic Asthma

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