Magnetic Composite Rapidly Treats <i>Staphylococcus aureus</i>‐Infected Osteomyelitis through Microwave Strengthened Thermal Effects and Reactive Oxygen Species

Jin, Lu; Zheng, Yufeng; Liu, Xiangmei; Li, Zhaoyang; Liang, Yanqin; Zhu, Shengli; Jiang, Hui; Cui, Zhenduo; Wu, S. L.

doi:10.1002/smll.202204028

Cited by 26 publications

(16 citation statements)

References 84 publications

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“…However, as mentioned above, large doses of antibiotics can cause the emergence of bacterial resistance, and long-term antibiotic treatment and invasive debridement can be detrimental to patient health [12][13][14]. Therefore, many other treatments have been reported to replace antibiotic therapy for osteomyelitis, such as photodynamic, photothermal, and microwave (MV) therapy [15,16]. However, the weak tissue penetration of near infrared (NIR) radiation greatly reduces its therapeutic efficacy for deep-tissue infectious diseases such as osteomyelitis [8,17].…”

Section: Ivyspring International Publishermentioning

confidence: 99%

Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties

Wang¹,

Mu²,

He³

et al. 2023

Theranostics

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Background: The current clinical treatment of osteomyelitis is limited by the emergence of drug-resistant bacteria, which often leads to the failure of traditional antibiotic treatment and large bone defects. Sonodynamic therapy (SDT) is a new strategy that is widely used to overcome the problem of bacterial resistance to antibiotic therapy as well as poor tissue penetration using near-infrared light in photodynamic therapy (PDT). Therefore, it is necessary to develop a new sonosensitizer that can kill bacteria and promote bone repair. Methods: Herein, we developed a sonosensitizer, porphyrin metal-organic framework (HNTM), with a Schottky junction modified by Ti 3 C 2 nanosheets (HN-Ti 3 C 2 ) for highly efficient sonodynamic therapy of osteomyelitis and bone regeneration. Results: Ti 3 C 2 greatly improves the acoustic catalytic performance by rapidly transferring the charge carriers generated by HNTM under ultrasound (US) irradiation, which killing drug-resistant bacteria through the generation of large amounts of reactive oxygen species (ROS). And HN-Ti 3 C 2 shows excellent 99.75% antibacterial effectiveness against MRSA. In addition, HN-Ti 3 C 2 generates a sonocurrent under low-intensity US to promote the repair of bone defects for a long time period. Mechanistic research using CCK-8 and RNA-seq showed that HN-Ti 3 C 2 nanocomposites can promote the proliferation of stem cells by regulating the cell cycle, DNA replication, and apoptosis. In addition, after low-intensity US irradiation, HN-Ti 3 C 2 promotes osteogenic differentiation via some key signaling pathways, including the calcium, Wnt, and TGF-beta signaling pathways, according to the Kyoto Encyclopedia of Genes and Genomes (KEGG). In a MRSA-infected rat tibial osteomyelitis model, HN-Ti 3 C 2 successfully eliminated the infection and significantly improved bone regeneration under US irradiation. Conclusion: This study indicates that engineered HN-Ti 3 C 2 is a distinctive nanocomposite for successful osteomyelitis treatment.

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Section: Ivyspring International Publishermentioning

confidence: 99%

Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties

Wang¹,

Mu²,

He³

et al. 2023

Theranostics

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“…Prior research has discovered a decrease in photoluminescence (PL) spectra, demonstrating that extreme molecularity facilitates the formation of electrons. [16,24] The PL peaks of CeO 2 , CuCeO x 9, CuCeO x 5, and CuCeO x 3 in brine were reduced under MW irradiation (Figure S7, Supporting Information). According to several studies, electric intensity fields in saline conditions ionize sodium compounds that produce free protons and electrons in the brine, which are further trapped by the surrounding oxygen species, generating free radicals.…”

Section: Mw Thermal Response and Mw Dynamic Response Mechanism Of Cuc...mentioning

confidence: 99%

“…[16,23] Microwave (MW) therapy is promising, as it can penetrate deep into biological tissue with few side effects. [23,24] Antibiotics are often used in conjunction with microwave therapy, but resistance can easily develop. Combinations of nanoparticles are used for cancer and antimicrobial treatments by using nanoparticles to enhance microwave efficiency or using microwaves to trigger the release of nanomedicines.…”

Section: Introductionmentioning

confidence: 99%

“…Microwave thermal therapy (MWTT) has been widely used as another typical microwave-based treatment method because heat generation under microwave irradiation causes thermal damage to bacteria. [23,24,27] However, various factors still limit its application. If the temperature is too high, there will be some warm areas in the microwave process that cannot completely kill the bacteria, thus hindering the therapeutic effect.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

CuCeO Bimetallic Oxide Rapidly Treats Staphylococcus aureus‐Infected Osteomyelitis through Microwave Strengthened Microwave Catalysis and Fenton‐Therapy

et al. 2023

Self Cite

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Osteomyelitis caused by bacteria is a deep-seated lesion and is often treated clinically with antibiotics. Long-term use of antibiotics may predispose bacteria to develop resistance. Here, CuCeO x material is applied to treat infectious bacterial osteomyelitis using microwave (MW)-assisted bacterial killing. Heat generation occurs as a result of the dielectric properties of the material under MW irradiation, and the material generates reactive oxygen species (ROS) under MW irradiation. Heat and ROS increase the thermal sensitivity and permeability of bacterial cell membranes, and the released copper ions easily penetrate the bacterial membrane and react with H 2 O 2 to produce a toxic hydroxyl group inside the bacteria, leading to the bacteria's eventual death. This is due to the synergistic effect of the MW thermal effect, ROS, and the breaking of the equilibrium within the bacteria. CuCeO x can effectively treat osteomyelitis caused by Staphylococcus aureus using MW irradiation. This study can safely and effectively address the challenge of deep tissue infections by shedding light on non-invasive antimicrobial systems and using MW thermal therapy and MW dynamics to achieve therapeutic results.

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“…In addition to promoting bone repair, some hemostatic materials with antimicrobial properties can be used to treat osteomyelitis. For example, magnetic composites prepared from molybdenum disulfide and iron oxide have been used to treat bacterially infected osteomyelitis effectively 260 .…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the medical applications of hemostatic materials

Yu¹,

Wang²,

Liu³

et al. 2023

Theranostics

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Bleeding caused by trauma or surgery is a serious health problem, and uncontrollable bleeding can result in death. Therefore, developing safe, effective, and convenient hemostatic materials is important. Active hemostatic agents currently used to investigate the field of hemostasis are divided into four broad categories: natural polymers, synthetic polymers, inorganic materials, and metal-containing materials. Hemostatic materials are prepared in various forms for wound care applications based on the active ingredients used. These materials include nanofibers, gels, sponges, and nanoparticles. Hemostatic materials find their applications in the field of wound care, and they are also used for hemostasis during malignant tumor surgery. Prompt and effective hemostasis can reduce the possibility of the spread of tumor cells with blood. This review discusses the outcomes of current research conducted in the field and the problems persisting in the field of developing hemostatic materials. The review also presents a platform for the further development of hemostatic materials. Bleeding caused by trauma or surgery is a serious health problem, and uncontrollable bleeding can result in death. Therefore, developing safe, effective, and convenient hemostatic materials is important. Active hemostatic agents currently used to investigate the field of hemostasis are divided into four broad categories: natural polymers, synthetic polymers, inorganic materials, and metal-containing materials. Hemostatic materials are prepared in various forms for wound care applications based on the active ingredients used. These materials include nanofibers, gels, sponges, and nanoparticles. Hemostatic materials find their applications in the field of wound care, and they are also used for hemostasis during malignant tumor surgery. Prompt and effective hemostasis can reduce the possibility of the spread of tumor cells with blood. This review discusses the outcomes of current research conducted in the field and the problems persisting in the field of developing hemostatic materials. The review also presents a platform for the further development of hemostatic materials.

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Magnetic Composite Rapidly Treats Staphylococcus aureus‐Infected Osteomyelitis through Microwave Strengthened Thermal Effects and Reactive Oxygen Species

Cited by 26 publications

References 84 publications

Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties

Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties

CuCeO Bimetallic Oxide Rapidly Treats Staphylococcus aureus‐Infected Osteomyelitis through Microwave Strengthened Microwave Catalysis and Fenton‐Therapy

Recent advances in the medical applications of hemostatic materials

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