Magnetic drug targeting by ferromagnetic microwires implanted within blood vessels

Hournkumnuard, Kanok; Natenapit, Mayuree

doi:10.1118/1.4805097

Cited by 19 publications

(16 citation statements)

References 26 publications

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“…Hofmann-Amtenbrink et al mentioned in 2009 that directing magnetic nanoparticles to any cell, tissue or tumor in the body was unrealistic as the magnetic force is not high enough to guide the particles through the blood system [ 53 ]. Hournkumnuard and Natenapit determined by simulation, that an externally applied magnetic field strength of not greater than 0.8 T significantly improved the effectiveness of concentrating ferromagnetic drug carrier nanoparticles around a ferromagnetic target microwire within a small vein [ 54 ]. Considering these facts and following the other part of our project, we worked with a strong electromagnet, which induced a magnetic field of around 1.8 T on the mouse skin during the application.…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties

et al. 2018

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BackgroundIn orthopedic surgery, implant-associated infections are still a major problem. For the improvement of the selective therapy in the infection area, magnetic nanoparticles as drug carriers are promising when used in combination with magnetizable implants and an externally applied magnetic field. These implants principally increase the strength of the magnetic field resulting in an enhanced accumulation of the drug loaded particles in the target area and therewith a reduction of the needed amount and the risk of undesirable side effects. In the present study magnetic nanoporous silica core–shell nanoparticles, modified with fluorophores (fluorescein isothiocyanate/FITC or rhodamine B isothiocyanate/RITC) and poly(ethylene glycol) (PEG), were used in combination with metallic plates of different magnetic properties and with a magnetic field. In vitro and in vivo experiments were performed to investigate particle accumulation and retention and their biocompatibility.ResultsSpherical magnetic silica core–shell nanoparticles with reproducible superparamagnetic behavior and high porosity were synthesized. Based on in vitro proliferation and viability tests the modification with organic fluorophores and PEG led to highly biocompatible fluorescent particles, and good dispersibility. In a circular tube system martensitic steel 1.4112 showed superior accumulation and retention of the magnetic particles in comparison to ferritic steel 1.4521 and a Ti90Al6V4 control. In vivo tests in a mouse model where the nanoparticles were injected subcutaneously showed the good biocompatibility of the magnetic silica nanoparticles and their accumulation on the surface of a metallic plate, which had been implanted before, and in the surrounding tissue.ConclusionWith their superparamagnetic properties and their high porosity, multifunctional magnetic nanoporous silica nanoparticles are ideal candidates as drug carriers. In combination with their good biocompatibility in vitro, they have ideal properties for an implant directed magnetic drug targeting. Missing adverse clinical and histological effects proved the good biocompatibility in vivo. Accumulation and retention of the nanoparticles could be influenced by the magnetic properties of the implanted plates; a remanent martensitic steel plate significantly improved both values in vitro. Therefore, the use of magnetizable implant materials in combination with the magnetic nanoparticles has promising potential for the selective treatment of implant-associated infections.Electronic supplementary materialThe online version of this article (10.1186/s12951-018-0422-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties

et al. 2018

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“…394 Similarly, dilute microferrimagnetic wires implanted within blood vessels in combination with an externally applied magnetic field can provide specific enrichment of simultaneously administered ferromagnetic NPs. 395 The challenge of NP enrichment in deeper body regions was addressed by He and co-workers, who deployed Halbach-like magnet arrays. 396 Nacev et al also developed a sophisticated approach based on fast magnetic pulses on ferromagnetic rods that led to reversing the sign of the potential energy term in Earnshaw’s theorem.…”

Section: In Vivo Treatment (“Particle-based Delivery”)mentioning

confidence: 99%

Diverse Applications of Nanomedicine

Pelaz¹,

et al. 2017

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The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic.

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“…Commonly, a permanent magnet is placed in the targeted area, for example, ferric steel implants, which were placed in the subarachnoid space of an in vitro human spine model [ 13 ]. An interesting concept in the context of cardiovascular diseases includes diluted microferrimagnetic wires implanted within blood vessels, which, under an externally applied magnetic field, provide specific enrichment of simultaneously administered ferromagnetic nanoparticles [ 14 ]. An example of successful application of magnetically targeted drug delivery to a tumor was reported by Tietze et al in 2013 [ 8 ], whereby intra-arterially administered drug-loaded SPIONs accumulated in tumor tissue by externally applied magnetic fields generated by a strong electromagnet.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Tissue Plasminogen Activator—Functionalized Superparamagnetic Iron Oxide Nanoparticles for Targeted Fibrin Clot Dissolution

Heid

Unterweger

Tietze

et al. 2017

IJMS

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Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted great attention in many biomedical fields and are used in preclinical/experimental drug delivery, hyperthermia and medical imaging. In this study, biocompatible magnetite drug carriers, stabilized by a dextran shell, were developed to carry tissue plasminogen activator (tPA) for targeted thrombolysis under an external magnetic field. Different concentrations of active tPA were immobilized on carboxylated nanoparticles through carbodiimide-mediated amide bond formation. Evidence for successful functionalization of SPIONs with carboxyl groups was shown by Fourier transform infrared spectroscopy. Surface properties after tPA immobilization were altered as demonstrated by dynamic light scattering and ζ potential measurements. The enzyme activity of SPION-bound tPA was determined by digestion of fibrin-containing agarose gels and corresponded to about 74% of free tPA activity. Particles were stored for three weeks before a slight decrease in activity was observed. tPA-loaded SPIONs were navigated into thrombus-mimicking gels by external magnets, proving effective drug targeting without losing the protein. Furthermore, all synthesized types of nanoparticles were well tolerated in cell culture experiments with human umbilical vein endothelial cells, indicating their potential utility for future therapeutic applications in thromboembolic diseases.

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Magnetic drug targeting by ferromagnetic microwires implanted within blood vessels

Abstract: The effectiveness of concentrating DCNPs of an average radius not larger than 100 nm around the target wire within a small vein was significantly improved using an externally applied magnetic field strength of not greater than 0.8 T.

Cited by 19 publications

References 26 publications

In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties

In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties

Diverse Applications of Nanomedicine

Synthesis and Characterization of Tissue Plasminogen Activator—Functionalized Superparamagnetic Iron Oxide Nanoparticles for Targeted Fibrin Clot Dissolution

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