Magnetic Levitational Assembly for Living Material Fabrication

Tasoğlu, Savaş; Yu, Chu Hsiang; Liaudanskaya, Volha; Güven, Sinan; Migliaresi, Claudio; Demirci, Utkan

doi:10.1002/adhm.201500092

Cited by 89 publications

(92 citation statements)

References 37 publications

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“…These advantages include the ability to create geometrically complex scaffolds containing viable cells [18,19,21], efficiency, low cost [22], high throughput [23], precise reproducibility [18], and limited need for specialized training. High-throughput fabrication of 3D structures is currently limited with traditional microfabrication techniques that generate 2D building blocks and rely on layer-by-layer assembly to form 3D structures [24][25][26][27][28][29][30][31][32]. Current methods for co-culturing multiple cell types in desired configurations lack high-throughput capabilities, demanding multiple labor-intensive fabrication steps [23], but spatial patterning of different cell types or ECM components is possible using various 'bio-inks' for printing [33].…”

mentioning

confidence: 99%

Bioprinting for cancer research

Knowlton

Önal

et al. 2015

Trends in Biotechnology

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338

233

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mentioning

confidence: 99%

Bioprinting for cancer research

Knowlton

Önal

et al. 2015

Trends in Biotechnology

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338

233

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“…Finally, using magnetically functionalized electrospun matrices with magnetic nanoparticles [23] as well as using tissue spheroids biofabricated from cells labelled with magnetic nanoparticles [24][25][26][27] will enable the development of novel magnetic 3D bioprinting technology based on principles of magnetic levitation or translocation of tissue constructs using magnetic forces [28][29][30] .…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that tissue spheroids can attach, spread and fuse on synthetic electrospun matrices [21,22] . Moreover, recently reported magnetic functionalization of electrospun synthetic matrices with magnetic nanoparticles [23] as well as biofabrication of tissue spheroids from cells labelled with magnetic nanoparticles [24][25][26][27] allow the development of magnetic forcesdriven biofabrication and even 3D magnetic bioprinting based on principles of magnetic levitation [28][29][30] . Thus, application of nanotechnology can enable development of novel technology of magnetic 3D bioprinting.…”

Section: Introductionmentioning

confidence: 99%

Patterning of tissue spheroids biofabricated from human fibroblasts on the surface of electrospun polyurethane matrix using 3D bioprinter

Mironov¹,

Khesuani²,

Буланова³

et al. 2024

IJB

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Patterning of tissue spheroids biofabricated from human fibroblasts on the surface of electrospun polyurethane matrix using 3D bioprinter. © 2016 Elizabeth V. Koudan, et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 45 RESEARCH ARTICLEPatterning of tissue spheroids biofabricated from human fibroblasts on the surface of electrospun polyurethane matrix using 3D bioprinter Abstract: Organ printing is a computer-aided additive biofabrication of functional three-dimensional human tissue and organ constructs according to digital model using the tissue spheroids as building blocks. The fundamental biological principle of organ printing technology is a phenomenon of tissue fusion. Closely placed tissue spheroids undergo tissue fusion driven by surface tension forces. In order to ensure tissue fusion in the course of post-printing, tissue spheroids must be placed and maintained close to each other. We report here that tissue spheroids biofabricated from primary human fibroblasts could be placed and maintained on the surface of biocompatible electrospun polyurethane matrix using 3D bioprinter according to desirable pattern. The patterned tissue spheroids attach to polyurethane matrix during several hours and became completely spread during several days. Tissue constructions biofabricated by spreading of patterned tissue spheroids on the biocompatible electrospun polyurethane matrix is a novel technological platform for 3D bioprinting of human tissue and organs.

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confidence: 99%

“…[81] The developed scaffold was later implanted in a bone defect model of New Zealand white rabbits. [81] The study aimed at assessing osteogenesis upon the application of an external static magnetic field. The scaffolds under the external magnetic field promoted higher osteocalcin expression in the bone defect, faster achievement of cortical bone and medullar cavity continuity when compared to scaffolds without magnetic stimulation.…”

mentioning

confidence: 99%