Magnetic nanoparticles as new diagnostic tools in medicine

Niemirowicz, Katarzyna; Markiewicz, Karolina H.; Wilczewska, Agnieszka Z.; Car, Halina

doi:10.2478/v10039-012-0031-9

Cited by 114 publications

(67 citation statements)

References 113 publications

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“…25,30 Stöber methods were used to obtain core-shell magnetic nanostructures with terminal propylamine groups. 26,31 Immobilization of CHX onto the surface of nanoparticles was achieved by interaction between the primary amine group of nanoparticles and the chloride group from CHX.…”

Section: Materials and Methods Synthesis Of Magnetic Nanoparticles Fumentioning

confidence: 99%

“…24 Among the many types of nanostructures, core-shell magnetic iron oxide nanoparticles are the most commonly used drug carriers in biomedical studies. 20,25 Due to their unique properties (size, magnetic moment, surface properties), the use of magnetic nanomaterials (MNPs) may represent a new approach for the treatment of infections caused by drugresistant pathogens. These nanoparticles are able to interact with planktonic bacteria as well as those embedded in a biofilm matrix.…”

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confidence: 99%

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Use of magnetic nanoparticles as a drug delivery system to improve chlorhexidine antimicrobial activity

Tokajuk

Niemirowicz

Deptuła

et al. 2017

IJN

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Nanotechnology offers new tools for developing therapies to prevent and treat oral infections, particularly biofilm-dependent disorders, such as dental plaques and endodontic and periodontal diseases. Chlorhexidine (CHX) is a well-characterized antiseptic agent used in dentistry with broad spectrum activity. However, its application is limited due to inactivation in body fluid and cytotoxicity toward human cells, particularly at high concentrations. To overcome these limitations, we synthesized nanosystems composed of aminosilane-coated magnetic nanoparticles functionalized with chlorhexidine (MNP@CHX). In the presence of human saliva, MNPs@CHX displayed significantly greater bactericidal and fungicidal activity against planktonic and biofilm-forming microorganisms than free CHX. In addition, CHX attached to MNPs has an increased ability to restrict the growth of mixed-species biofilms compared to free CHX. The observed depolarization of mitochondria in fungal cells treated with MNP@CHX suggests that induction of oxidative stress and oxidation of fungal structures may be a part of the mechanism responsible for pathogen killing. Nanoparticles functionalized by CHX did not affect host cell proliferation or their ability to release the proinflammatory cytokine, IL-8. The use of MNPs as a carrier of CHX has great potential for the development of antiseptic nanosystems.

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Section: Materials and Methods Synthesis Of Magnetic Nanoparticles Fumentioning

confidence: 99%

mentioning

confidence: 99%

Use of magnetic nanoparticles as a drug delivery system to improve chlorhexidine antimicrobial activity

Tokajuk

Niemirowicz

Deptuła

et al. 2017

IJN

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“…[8][9][10][11] There is now a wealth of data suggesting that certain properties of magnetic nanoparticles, such as resistance to biodegradation processes, surface activity, and ability to penetrate bacterial cell membranes, are useful for development of new antibacterial therapies. Many studies have shown divergent effects of nanoparticles against bacteria which could be linked with dose, nature of A very promising future lies ahead for the application of functionalized superparamagnetic iron oxide nanoparticles (SPIONs) and their potential for magnetic targeting to bacterial cells and biofilm mass.…”

Section: Introductionmentioning

confidence: 99%

Gold-functionalized magnetic nanoparticles restrict growth of Pseudomonas aeruginosa

Niemirowicz¹,

Święcicka²,

Wilczewska³

et al. 2014

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) and their derivatives (aminosilane and gold-coated) have been widely investigated in numerous medical applications, including their potential to act as antibacterial drug carriers that may penetrate into bacteria cells and biofilm mass. Pseudomonas aeruginosa is a frequent cause of infection in hospitalized patients, and significant numbers of currently isolated clinical strains are resistant to standard antibiotic therapy. Here we describe the impact of three types of SPIONs on the growth of P. aeruginosa during long-term bacterial culture. Their size, structure, and physicochemical properties were determined using transmission electron microscopy, X-ray diffraction analysis, and Fourier transform infrared spectroscopy. We observed significant inhibition of P. aeruginosa growth in bacterial cultures continued over 96 hours in the presence of gold-functionalized nanoparticles (Fe 3 O 4 @Au). At the 48-hour time point, growth of P. aeruginosa , as assessed by the number of colonies grown from treated samples, showed the highest inhibition (decreased by 40%). These data provide strong evidence that Fe 3 O 4 @Au can dramatically reduce growth of P. aeruginosa and provide a platform for further study of the antibacterial activity of this nanomaterial.

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“…Magnetic NPs consisting of magnetite (Fe 3 O 4 ) possess unique characteristics that make them promising agents for antibacterial applications [71] because the Food and Drug Administration approved that superparamagnetic iron oxide nanoparticles are biocompatible with human body [72]. It is interesting to mention that only magnetite particles with size of less than 30 nm have a large surface area and exhibits superparamagnetic properties that make them prone to magnetic fields and they do not become permanently magnetized without an external magnetic field to support them.…”

Section: Chitosan Magnetic Nanoparticlesmentioning

confidence: 99%

Chitosan: A Promising Substrate for Regenerative Medicine in Drug Formulation

Kashyap

Archana

Semwal³

et al. 2015

Springer Series on Polymer and Composite Materials

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Chitosan plays a most important role in the regenerative medication for wound healing. The adhesive nature of chitosan, with their antifungal and bactericidal character, and their permeability to oxygen, is a very important property associated with the treatment of wounds. Different derivatives and combination of chitosan have been reported for this purpose in the form of hydrogels, fibers, membranes, scaffolds and sponges. The purpose of the chapter is to have a closer look in the work done directly by different researchers on the chitosan formulation with potential medicinal applications to provide a better understanding of its usability in regenerative medicine.

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Magnetic nanoparticles as new diagnostic tools in medicine

Cited by 114 publications

References 113 publications

Use of magnetic nanoparticles as a drug delivery system to improve chlorhexidine antimicrobial activity

Use of magnetic nanoparticles as a drug delivery system to improve chlorhexidine antimicrobial activity

Gold-functionalized magnetic nanoparticles restrict growth of Pseudomonas aeruginosa

Chitosan: A Promising Substrate for Regenerative Medicine in Drug Formulation

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